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DNA Labs India

HLA DNA High Resolution Typing - B Locus Test

DNA Labs India | ISO 9001:2015 Certified

HLA DNA High Resolution Typing - B Locus Test

Short Name: HLA-B Typing

Also known as: HLA-B High Resolution Typing, HLA DNA Typing B Locus

HLA DNA High Resolution Typing - B Locus Test test available at DNA Labs India for ₹8,000. Uses PCR, Sequencing on Whole Blood or Buccal Swab samples. Results in 10-12 days. Free home collection in 300+ cities across India.

Molecular Genetic Test🏠 Home Collection

🩺 Medically Reviewed By

Overview

To determine HLA-B allele compatibility for transplantation and to assist in the diagnosis of autoimmune diseases.

Test Code
801
Price
₹8,000
Sample Type
Whole Blood or Buccal Swab
Result Time
10-12 days
Fasting Required
No
Method
PCR, Sequencing
Step 1

Sample Collection

No special preparation required. Ensure proper patient identification and consent.

Method: Venipuncture or Buccal swab collection

Step 2

Laboratory Analysis

Blood is drawn via venipuncture into specified tubes, or a buccal swab is collected from the inner cheek using a sterile swab.

Step 3

Report Delivery

Apply pressure to the puncture site for blood draw; store samples as instructed and ship refrigerated.

Timeline: 10-12 days

Patient Instructions

1
Before the Test:No fasting required. Provide accurate medical history and sign informed consent.
2
During the Test:Sample collection takes about 10-15 minutes; procedure is minimally invasive.
3
After the Test:Results are available in 10-12 days; follow up with your healthcare provider for interpretation.

About This Test

Who Should Get This Test

To determine HLA-B allele compatibility for transplantation and to assist in the diagnosis of autoimmune diseases.

How to Prepare

  • Use specified EDTA or ACD tubes for blood collection
  • Ship samples refrigerated; do not freeze
  • For buccal swab, collect in a sterile container and avoid contamination
  • Label samples correctly with patient details

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"This test is critical for ensuring donor-recipient compatibility in bone marrow transplants and provides insights into autoimmune disease risk."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole Blood or Buccal Swab
Sample Volume4 mL whole blood or 6 mL whole blood or Buccal swab
ContainerLavender Top (EDTA) tube, Yellow Top (ACD) tube, or Sterile container for buccal swab
Collection MethodVenipuncture or Buccal swab collection

Sample Stability

Refrigerated96 hours
Room TemperatureNot recommended
FrozenNot applicable
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Contaminated buccal swabs
  • Improper labeling or documentation

Understanding Your Results

Results indicate the specific HLA-B alleles identified. In transplantation, a higher degree of allele matching improves compatibility and outcomes.
📊

Matching alleles at high resolution reduces transplant risks such as graft rejection.

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Certain HLA-B alleles are associated with increased risk or diagnosis of autoimmune conditions.

⚠️ When to Consult a Doctor:

If you have symptoms of autoimmune disease or are undergoing transplant evaluation, consult your doctor for test interpretation and next steps.

Limitations

  • Tests only HLA-B locus; other HLA loci may require separate tests for full compatibility
  • Requires specialized laboratory and expertise for accurate results
  • Results may be affected by sample quality or technical errors

Risks & Considerations

  • Minor bruising or soreness at blood draw site
  • Rare risk of infection at puncture site
  • Discomfort during buccal swab collection

Interfering Factors

  • Hemolyzed blood samples
  • Contaminated buccal swabs
  • Improper storage conditions leading to DNA degradation

Frequently Asked Questions

What is the HLA DNA High Resolution Typing - B Locus Test?
It is a genetic test that identifies specific alleles of the HLA-B gene, crucial for transplant compatibility and autoimmune disease diagnosis.
Why is high-resolution typing important for transplantation?
High-resolution typing ensures precise matching between donor and recipient, reducing the risk of graft rejection or graft-versus-host disease.
What samples are required for the test?
4 mL whole blood in EDTA or ACD tube, or a buccal swab collected in a sterile container.
How is the test performed?
DNA is extracted from the sample and analyzed using PCR and sequencing techniques to identify HLA-B alleles.
What is the turnaround time for results?
Results are typically available in 10-12 days.
Is fasting required before the test?
No, fasting is not required. No special preparation is needed.
Can this test diagnose autoimmune diseases?
Yes, certain HLA-B alleles are associated with autoimmune conditions like lupus and rheumatoid arthritis, aiding in diagnosis.
What are the risks of the test?
Risks are minimal, including minor bruising from blood draw or discomfort from buccal swab collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across India.
What is the cost of the test?
The test costs INR 8000, with home collection included.
How accurate is the test?
The test is highly accurate when performed in accredited laboratories using standardized PCR and sequencing methods.
How do I interpret the results?
Consult your doctor or genetic counselor to understand the implications for transplant compatibility or autoimmune disease risk.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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