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DNA Labs India

Chimerism Post-Engraftment Test

DNA Labs India | ISO 9001:2015 Certified

Chimerism Post-Engraftment Test

Short Name: Chimerism Post-Engraftment

Also known as: Chimerism Analysis, Engraftment Chimerism Test, Donor Chimerism Test

Chimerism Post-Engraftment Test test available at DNA Labs India for ₹8,000. Uses PCR, STR Analysis, Fragment Analysis on Whole blood or Bone marrow samples. Results in 7 working days. Free home collection in 300+ cities across India.

Molecular Genetics Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

To monitor the success of bone marrow or stem cell transplant by detecting donor and recipient DNA profiles, assessing engraftment status, and identifying early complications.

Test Code
289
Price
₹8,000
Sample Type
Whole blood or Bone marrow
Result Time
7 working days
Fasting Required
No
Method
PCR, STR Analysis, Fragment Analysis
Step 1

Sample Collection

Indicate date of bone marrow transplant.

Method: Blood draw or bone marrow aspiration

Step 2

Laboratory Analysis

Standard blood draw or bone marrow aspiration procedure performed by a trained phlebotomist or healthcare provider.

Step 3

Report Delivery

Sample must be shipped refrigerated; do not freeze.

Timeline: 7 working days

Patient Instructions

1
Before the Test:No specific preparation required, but provide the date of bone marrow transplant and any relevant medical history.
2
During the Test:Sample collection via blood draw or bone marrow aspiration, which may cause minor discomfort.
3
After the Test:Wait for the report, typically available in 7 working days. Resume normal activities unless advised otherwise.

About This Test

Who Should Get This Test

To monitor the success of bone marrow or stem cell transplant by detecting donor and recipient DNA profiles, assessing engraftment status, and identifying early complications.

How to Prepare

  • Indicate Date of Bone Marrow Transplant
  • Collect 4 ml whole blood or bone marrow in a Lavender Top (EDTA) tube
  • Ship refrigerated, do not freeze

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"This test is crucial for monitoring transplant success and early detection of complications like graft-versus-host disease, ensuring timely intervention."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole blood or Bone marrow
Sample Volume4 ml (2 ml min.)
ContainerLavender Top (EDTA) tube
Collection MethodBlood draw or bone marrow aspiration

Sample Stability

Refrigerator: 72 hours
Sample Rejection Criteria:
  • Hemolyzed samples
  • Incorrect container type
  • Sample not properly labeled or documented
  • Insufficient sample volume

Understanding Your Results

Results indicate the proportion of donor and recipient DNA, helping assess transplant success and potential complications.
Full donor chimerism (100% donor DNA): Suggests successful engraftment and donor cell dominance.
Mixed chimerism (both donor and recipient DNA present): Indicates partial engraftment; requires monitoring and possible intervention.
Full recipient chimerism (100% recipient DNA): May indicate graft failure or rejection.
Changes in chimerism percentage over time can signal complications like GVHD or relapse.
⚠️ When to Consult a Doctor:

If experiencing symptoms of graft-versus-host disease (e.g., skin rash, diarrhea, liver issues), unexplained infections, or autoimmune disorders post-transplant.

Limitations

  • ⚠Cannot detect minor chimerism below the detection limit of the assay
  • ⚠Requires prior donor DNA profile for accurate comparison
  • ⚠Results may be influenced by sample quality or timing post-transplant

Risks & Considerations

  • ●Minimal risks from blood draw, such as bruising or infection
  • ●Rare discomfort from bone marrow aspiration

Interfering Factors

  • ●Contamination of sample
  • ●Recent blood transfusion
  • ●Improper sample storage or handling
  • ●Hemolyzed or degraded samples

Compare With Similar Tests

TestChimerism Post-Engraftment TestHLA TypingBone Marrow BiopsyGVHD Panel
ComparisonChimerism Post-Engraftment TestHLA typing is used pre-transplant for donor matching, while chimerism test monitors post-transplant DNA profiles.Bone marrow biopsy evaluates cell morphology, whereas chimerism test analyzes DNA composition.GVHD panel detects biomarkers for GVHD, while chimerism test assesses donor cell engraftment.

Frequently Asked Questions

What is the Chimerism Post-Engraftment Test?
It is a DNA test that detects the presence of donor and recipient DNA profiles in individuals after bone marrow or stem cell transplant to monitor engraftment success.
Why is this test performed?
To assess the success of a transplant, detect early complications like graft-versus-host disease, and guide treatment decisions.
How is the test conducted?
A blood or bone marrow sample is collected and analyzed using PCR and STR analysis to compare DNA profiles.
What is the cost of the Chimerism Post-Engraftment Test in India?
The cost is INR 8000 at DNA Labs India, with free home sample collection available across many cities.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home collection for online bookings in numerous cities across India.
How long does it take to get results?
Reports are typically available within 7 working days after sample collection.
What do the results mean?
Results show the percentage of donor versus recipient DNA; full donor chimerism indicates successful engraftment, while mixed or recipient chimerism may require further evaluation.
Are there any risks associated with the test?
Risks are minimal, including minor bruising from blood draw or discomfort from bone marrow aspiration.
How should I prepare for the test?
No fasting is required, but provide the date of your bone marrow transplant and follow collection instructions.
What sample is required for the test?
4 ml of whole blood or bone marrow in a Lavender Top (EDTA) tube, shipped refrigerated.
Can the test detect graft-versus-host disease (GVHD)?
The test assesses chimerism levels, which can help monitor for GVHD, but it is not a direct diagnostic test for GVHD symptoms.
Who should undergo this test?
Individuals who have received bone marrow or stem cell transplants, especially during follow-up care or if experiencing transplant-related complications.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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