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KCNH2 Gene Long QT syndrome type 2 NGS Genetic Test

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KCNH2 Gene Long QT syndrome type 2 NGS Genetic Test

Short Name: KCNH2 LQT2 NGS Test

Also known as: LQT2 Genetic Test, KCNH2 Mutation Analysis, Long QT Type 2 DNA Test

KCNH2 Gene Long QT syndrome type 2 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To diagnose Long QT syndrome type 2 by detecting pathogenic mutations in the KCNH2 gene using NGS technology, enabling early intervention and family screening.

Test Code
2543
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Clinical history review and genetic counseling session to draw a pedigree chart of affected family members.

Method: Venipuncture or FTA card

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or one drop on FTA card by trained phlebotomist.

Step 3

Report Delivery

Sample labeled and transported to the laboratory under stable conditions for DNA extraction and analysis.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling session to discuss test implications, family history, and obtain informed consent.
2
During the Test:DNA extraction from the sample followed by NGS sequencing of the KCNH2 gene.
3
After the Test:Report generation with detailed findings, followed by genetic counseling to explain results and next steps.

About This Test

Who Should Get This Test

To diagnose Long QT syndrome type 2 by detecting pathogenic mutations in the KCNH2 gene using NGS technology, enabling early intervention and family screening.

How to Prepare

  • Ensure proper sample labeling with patient details
  • Avoid hemolysis during blood collection
  • Store FTA card at room temperature if used

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic testing for KCNH2 mutations is vital for identifying Long QT syndrome type 2, enabling proactive management to prevent life-threatening arrhythmias and guide family screening."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or FTA card

Sample Stability

Blood in EDTA tube: 2-8°C for up to 48 hours
FTA card: Room temperature stable for extended periods
Sample Rejection Criteria:
  • Hemolyzed or clotted blood sample
  • Insufficient sample volume
  • Incorrect sample labeling or container

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the KCNH2 gene associated with Long QT syndrome type 2.
Positive: Pathogenic variant detected, consistent with LQT2 diagnosis; clinical correlation and family screening recommended.
Negative: No pathogenic variants detected; does not rule out other causes of symptoms.
Variant of uncertain significance: Further testing or family studies may be needed for clarification.
⚠️ When to Consult a Doctor:

If you experience symptoms like fainting, rapid heartbeat, or have a family history of Long QT syndrome, consult a cardiologist or genetic specialist immediately.

Limitations

  • ⚠May not detect all genetic variants or structural changes
  • ⚠Requires genetic counseling for accurate interpretation
  • ⚠Results may have variants of uncertain significance

Risks & Considerations

  • ●Minor bruising or discomfort at the blood draw site
  • ●Rare risk of infection at puncture site
  • ●Emotional impact of genetic results

Interfering Factors

  • ●Contaminated or degraded DNA sample
  • ●Technical errors in NGS sequencing
  • ●Sample mishandling during transport

Frequently Asked Questions

What is the KCNH2 Gene Long QT syndrome type 2 NGS Genetic Test?
It is a genetic test that uses Next-Generation Sequencing to analyze the KCNH2 gene for mutations causing Long QT syndrome type 2, a heart rhythm disorder.
Why is this test important?
Early diagnosis through this test can prevent life-threatening arrhythmias, guide treatment, and enable family screening for inherited risk.
What are the symptoms of Long QT syndrome type 2?
Symptoms include fainting, rapid or irregular heartbeat, chest pain, and shortness of breath, often triggered by stress or exercise.
How is the test performed?
A blood sample or DNA extract is analyzed using NGS technology to detect mutations in the KCNH2 gene.
What sample is required for the test?
Blood, extracted DNA, or one drop of blood on an FTA card can be used.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What is the cost of the test?
The test costs INR 20,000, with free home sample collection available across India.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities.
What does a positive result mean?
A positive result indicates a pathogenic mutation in the KCNH2 gene, confirming Long QT syndrome type 2 diagnosis and requiring medical management.
What does a negative result mean?
A negative result means no pathogenic variants were detected, but symptoms may still need evaluation for other causes.
Can this test be used for family screening?
Yes, if a mutation is identified, family members can be tested to assess their risk and guide preventive care.
How should I prepare for the test?
No fasting is required. Provide clinical history and attend a genetic counseling session before sample collection.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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