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LAMB3 Gene Amelogenesis imperfecta type 1A NGS Genetic Test

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LAMB3 Gene Amelogenesis imperfecta type 1A NGS Genetic Test

Short Name: LAMB3 AI Type 1A NGS Test

Also known as: LAMB3 Gene Test for AI Type 1A, Amelogenesis Imperfecta Type 1A Genetic Test, LAMB3 NGS Test

LAMB3 Gene Amelogenesis imperfecta type 1A NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

Next-Generation Sequencing (NGS) Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the LAMB3 gene that cause Amelogenesis Imperfecta Type 1A, enabling accurate diagnosis, management, and family planning.

Test Code
4827
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Consult with a healthcare provider or genetic counselor. Provide clinical history and family pedigree if available.

Method: Venipuncture or Blood Drop

Step 2

Laboratory Analysis

Blood sample will be collected via venipuncture or a blood drop on FTA card by a trained phlebotomist.

Step 3

Report Delivery

Apply pressure to the puncture site. Store sample as instructed and await report delivery.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling session to discuss test implications and draw a family pedigree chart.
2
During the Test:Sample collection procedure as per standard protocols.
3
After the Test:Wait for results and schedule follow-up with healthcare provider for interpretation.

About This Test

Who Should Get This Test

To identify mutations in the LAMB3 gene that cause Amelogenesis Imperfecta Type 1A, enabling accurate diagnosis, management, and family planning.

How to Prepare

  • Ensure proper identification of the patient
  • Use sterile equipment for blood collection
  • Label samples correctly with patient details
  • Transport samples at ambient temperature unless specified

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for AI Type 1A can guide treatment decisions and inform family planning, especially for hereditary conditions."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required
ContainerEDTA tube or FTA Card
Collection MethodVenipuncture or Blood Drop

Sample Stability

Blood in EDTA tube
Blood on FTA card
Sample Rejection Criteria:
  • Hemolyzed or clotted blood sample
  • Insufficient sample volume
  • Incorrect labeling or missing patient information

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the LAMB3 gene. Positive results confirm AI Type 1A, while negative results may require further testing if symptoms persist.
📊

Positive for pathogenic mutation

Confirms diagnosis of Amelogenesis Imperfecta Type 1A. Genetic counseling recommended.

📊

Negative for pathogenic mutation

No mutations detected in the LAMB3 gene. Consider other genetic or environmental causes.

📊

Variant of uncertain significance

Further testing or family studies may be needed for clarification.

⚠️ When to Consult a Doctor:

If symptoms of AI Type 1A are present, or if there is a family history of the disorder, consult a dentist or geneticist for evaluation and testing.

Limitations

  • ⚠May not detect all possible mutations in the LAMB3 gene
  • ⚠Requires genetic counseling for proper interpretation
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minimal risks from blood draw, such as bruising or infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Contaminated or degraded DNA sample
  • ●Improper sample collection or storage
  • ●Recent blood transfusion

Compare With Similar Tests

TestLAMB3 Gene Amelogenesis imperfecta type 1A NGS Genetic TestAMELX Gene TestENAM Gene TestComprehensive Dental Genetic Panel
ComparisonLAMB3 Gene Amelogenesis imperfecta type 1A NGS Genetic TestTests for mutations in the AMELX gene, another cause of AIAnalyzes the ENAM gene for AI-related mutationsIncludes multiple genes associated with dental disorders

Frequently Asked Questions

What is the LAMB3 Gene Amelogenesis Imperfecta Type 1A NGS Genetic Test?
It is a genetic test that uses Next-Generation Sequencing to analyze the LAMB3 gene for mutations causing Amelogenesis Imperfecta Type 1A, a disorder affecting tooth enamel.
Who should take this test?
Individuals with symptoms like discolored, fragile teeth, or a family history of Amelogenesis Imperfecta should consider this test.
What are the symptoms of AI Type 1A?
Common symptoms include discolored teeth, abnormal tooth shape, fragile teeth prone to breakage, increased susceptibility to decay, and sensitivity to temperatures.
How is the test performed?
A blood sample or DNA is collected and analyzed using NGS technology to detect mutations in the LAMB3 gene.
What is the cost of the test?
The test costs INR 20000 at DNA Labs India, with free home sample collection available.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What do the results mean?
Positive results confirm AI Type 1A due to LAMB3 gene mutations, while negative results may indicate other causes. Genetic counseling is recommended for interpretation.
Is genetic counseling required before testing?
Yes, a genetic counseling session is recommended to discuss test implications and family history.
Can this test be used for prenatal diagnosis?
This test is primarily for postnatal diagnosis; prenatal testing may require specialized procedures and consultation.
What are the risks of the test?
Risks are minimal, mainly related to blood draw, such as bruising. Psychological impacts of results should be considered.
How accurate is the test?
The test uses advanced NGS technology for high accuracy, but results should be correlated with clinical findings and genetic counseling.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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