LAMP2 Gene Danon disease NGS Genetic Test
Short Name: Danon Disease NGS Test
Also known as: LAMP2 Deficiency, Danon Disease Genetic Test, LAMP2-Related Cardiomyopathy Test
LAMP2 Gene Danon disease NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 3, 2026
Overview
The purpose of this test is to identify mutations in the LAMP2 gene that cause Danon disease, enabling accurate diagnosis, guiding treatment strategies, and facilitating family planning through genetic counseling.
- Test Code
- 5252
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
Provide clinical history of the patient, including symptoms and family history. A genetic counseling session is recommended to draw a pedigree chart of affected family members.
Method: Venipuncture or finger prick
Laboratory Analysis
Standard blood draw procedure using venipuncture or finger prick for FTA card. Ensure proper labeling and handling of samples.
Report Delivery
Sample is processed for DNA extraction and NGS analysis. Store sample as per laboratory guidelines.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify mutations in the LAMP2 gene that cause Danon disease, enabling accurate diagnosis, guiding treatment strategies, and facilitating family planning through genetic counseling.
How to Prepare
- Fast for 4-8 hours if required, though not mandatory for this test
- Avoid strenuous exercise before sample collection
- Inform the lab of any medications or recent transfusions
- Use sterile equipment for blood collection
- Label samples correctly with patient details
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Early genetic testing for Danon disease is crucial for managing cardiac risks and informing family planning decisions, especially in X-linked inheritance patterns."
Last medically reviewed: September 3, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume
- Incorrect sample container or labeling
- Sample contaminated or degraded
Understanding Your Results
Pathogenic variant detected
Confirms diagnosis of Danon disease. Recommend clinical management and family screening.
No pathogenic variant detected
Danon disease unlikely, but clinical correlation is needed. Consider other genetic or non-genetic causes.
Variant of uncertain significance (VUS)
Further testing or family studies may be required. Genetic counseling advised.
Consult a doctor if you experience symptoms like chest pain, muscle weakness, or cognitive issues, or if there is a family history of Danon disease. Genetic counseling is recommended before and after testing.
Limitations
- ⚠May not detect all types of genetic mutations, such as large deletions or deep intronic variants
- ⚠Results require clinical correlation and are not standalone diagnostic
- ⚠Cannot predict disease severity or progression accurately
- ⚠Variants of uncertain significance (VUS) may be identified, requiring further evaluation
Risks & Considerations
- ●Minor bruising or discomfort at blood draw site
- ●Rare risk of infection
- ●Emotional impact of genetic results
Interfering Factors
- ●Poor sample quality or insufficient DNA
- ●Contamination during sample collection or processing
- ●Hemolyzed blood sample
- ●Recent blood transfusion affecting DNA analysis
Compare With Similar Tests
| Test | LAMP2 Gene Danon disease NGS Genetic Test | Cardiac MRI | Muscle Biopsy | ECG/Echocardiogram | Single-Gene Sequencing |
|---|---|---|---|---|---|
| Comparison | LAMP2 Gene Danon disease NGS Genetic Test |
Frequently Asked Questions
What is Danon disease?
How is the LAMP2 Gene Danon Disease NGS Genetic Test performed?
What is the cost of this test?
Who should consider this test?
How long does it take to get results?
Is home sample collection available?
What sample is required for the test?
Is fasting required before the test?
What do the results mean?
Can this test be used for prenatal diagnosis?
What are the limitations of this test?
How accurate is the NGS Genetic Test?
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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