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LDB3 Gene Cardiomyopathy, Hypertrophic, Type 24 NGS Genetic Test

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LDB3 Gene Cardiomyopathy, Hypertrophic, Type 24 NGS Genetic Test

Short Name: LDB3 Cardiomyopathy NGS

Also known as: Hypertrophic cardiomyopathy type 24, LDB3-related cardiomyopathy, LDB3 gene mutation analysis

LDB3 Gene Cardiomyopathy, Hypertrophic, Type 24 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Test reports are available within 3 to 4 weeks from the date the sample is received at the laboratory.. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

This test is used to identify pathogenic variants in the LDB3 gene in individuals with clinical or family history suggesting hypertrophic cardiomyopathy type 24. It aids in diagnostic confirmation, familial risk assessment and management planning.

Test Code
3941
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Test reports are available within 3 to 4 weeks from the date the sample is received at the laboratory.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No fasting is needed. A genetic counselling session will be arranged before testing to record clinical history and draw a pedigree chart of family members affected with LDB3 gene cardiomyopathy. Bring any previous cardiac test reports and doctor prescriptions.

Method: Peripheral venipuncture or FTA card blood spot

Step 2

Laboratory Analysis

A trained phlebotomist will collect a small volume of blood in an EDTA tube or prepare an FTA card sample. The procedure takes about 5 minutes.

Step 3

Report Delivery

You may resume normal activities immediately. No post-procedure restrictions are necessary.

Timeline: Test reports are available within 3 to 4 weeks from the date the sample is received at the laboratory.

Patient Instructions

1
Before the Test:No fasting is required. A genetic counselling session will be arranged to review the clinical history and family pedigree.
2
During the Test:Sample collection only; no sedation or special preparation is required.
3
After the Test:Wait for results and discuss the report with your cardiologist or clinical geneticist for personalised management.

About This Test

Who Should Get This Test

This test is used to identify pathogenic variants in the LDB3 gene in individuals with clinical or family history suggesting hypertrophic cardiomyopathy type 24. It aids in diagnostic confirmation, familial risk assessment and management planning.

How to Prepare

  • No fasting required.
  • A genetic counselling session is recommended before the test to document family history and draw a pedigree chart.
  • Inform the referring doctor about any medications, supplements, or previous cardiac surgery.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"If a pathogenic LDB3 variant is identified, a cardiologist should review the patient for phenotype correlation, risk stratification, and initiation of cascade screening in at-risk relatives."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required for NGS testing
ContainerEDTA vacutainer / FTA card / sterile tube for extracted DNA
Collection MethodPeripheral venipuncture or FTA card blood spot

Sample Stability

Whole blood (EDTA): stable at 2–8°C for up to 72 hours
FTA card: stable at room temperature for up to 4 weeks
Extracted DNA: stable long-term at -20°C
Sample Rejection Criteria:
  • Haemolysed or clotted sample
  • Insufficient sample quantity
  • Mislabeled or unlabeled sample
  • Leaked sample or damaged container
  • Sample received at incorrect temperature

Understanding Your Results

LDB3 gene variant analysis is reported using standard ACMG/AMP guidelines. The interpreting laboratory includes the variant classification, zygosity, and clinical correlation.
Pathogenic / Likely Pathogenic — supports a molecular diagnosis; family segregation testing is recommended.
Benign / Likely Benign — considered not causative.
Variant of Uncertain Significance (VUS) — cannot be classified; further family studies or additional testing may be required.
⚠️ When to Consult a Doctor:

If you have a family history of hypertrophic cardiomyopathy, unexplained cardiac symptoms, or an abnormal cardiac evaluation, consult a cardiologist or a clinical geneticist for genetic counseling and testing.

Limitations

  • ⚠Targeted NGS detects single nucleotide variants and small indels in LDB3 gene only.
  • ⚠Large gene rearrangements, deep intronic variants, and copy number variants may not be detected.
  • ⚠A negative result does not exclude genetic or non-genetic causes of HCM.
  • ⚠Variant classification may change as new evidence emerges.

Risks & Considerations

  • ●No significant risks. Minor bruising or pain at the venepuncture site may occur.

Interfering Factors

  • ●Poor DNA quality or quantity
  • ●Sample degradation during transport
  • ●Variants of uncertain significance may require additional testing
  • ●Presence of pseudogene sequences could affect analysis
  • ●NGS may not detect large deletions/duplications, trinucleotide repeat expansions, or mitochondrial variants

Compare With Similar Tests

TestLDB3 Gene Cardiomyopathy, Hypertrophic, Type 24 NGS Genetic Test
ComparisonLDB3 Gene Cardiomyopathy, Hypertrophic, Type 24 NGS Genetic Test

Frequently Asked Questions

What is LDB3 gene cardiomyopathy?
LDB3 gene cardiomyopathy, also known as hypertrophic cardiomyopathy type 24, is a genetic heart condition caused by a mutation in the LDB3 gene. It leads to thickening of the heart muscle and impaired pumping function.
What are the symptoms of LDB3 gene cardiomyopathy?
The common symptoms are chest pain, shortness of breath, dizziness or fainting during physical activity, palpitations and swelling in the legs or ankles. Some individuals may remain symptom-free for many years.
How is LDB3 gene cardiomyopathy diagnosed?
Diagnosis is based on a physical examination, medical history, ECG, echocardiography, cardiac MRI and genetic testing. Genetic testing confirms the specific LDB3 gene mutation responsible for the condition.
What is the cost of LDB3 NGS genetic test in India?
The approximate cost of LDB3 gene cardiomyopathy NGS genetic testing in India is Rs 20,000 at DNA Labs India. Free home sample collection is provided for online bookings.
Is fasting required for the LDB3 gene genetic test?
No, fasting is not required. You can continue your regular diet and medications unless otherwise advised by your doctor.
What sample is needed for the LDB3 gene NGS test?
The test can be done on whole blood, extracted DNA, or a single drop of blood spotted on an FTA card. Our collection team will provide the appropriate kit.
How long does it take to get the test report?
The report is usually available within 3 to 4 weeks after the sample is received at the laboratory.
What is NGS technology?
NGS stands for next-generation sequencing, a high-throughput DNA sequencing method that can accurately read multiple genes simultaneously to detect mutations associated with genetic disorders.
Does this test detect all causes of hypertrophic cardiomyopathy?
No, this test is specific to the LDB3 gene. Other genes can also cause HCM. A comprehensive cardiomyopathy gene panel should be considered if the LDB3 result is negative or if broader testing is required.
What does a positive LDB3 gene result mean?
A positive result means a pathogenic or likely pathogenic variant in LDB3 was identified. This confirms the molecular diagnosis of LDB3-related cardiomyopathy and supports screening of close relatives.
What does a negative LDB3 gene result mean?
A negative result means no pathogenic variant was detected in the LDB3 gene. However, it does not completely rule out genetic or non-genetic causes of cardiomyopathy; follow-up with a specialist is advised.
Can I get home sample collection for this test?
Yes, DNA Labs India offers free home sample collection for the LDB3 gene cardiomyopathy NGS genetic test in major cities across India. You can book online to schedule a convenient slot.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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