LRP5 Gene Osteoporosis pseudoglioma syndrome NGS Genetic Test
Short Name: LRP5 Gene OPPG NGS Test
Also known as: Osteoporosis Pseudoglioma Syndrome, OPPG, LRP5-related disorder
LRP5 Gene Osteoporosis pseudoglioma syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the LRP5 Gene OPPG NGS Genetic Test is to identify pathogenic mutations in the LRP5 gene associated with Osteoporosis Pseudoglioma Syndrome. This aids in accurate diagnosis, differentiation from other bone or eye disorders, risk assessment for family members, and personalized management strategies.
- Test Code
- 5095
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
Provide clinical history of the patient and undergo a genetic counseling session to draw a pedigree chart of affected family members.
Method: Venipuncture for blood or saliva collection
Laboratory Analysis
Sample collected via venipuncture for blood or saliva collection in a sterile container.
Report Delivery
Apply pressure to the puncture site; store sample at ambient room temperature as per instructions.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the LRP5 Gene OPPG NGS Genetic Test is to identify pathogenic mutations in the LRP5 gene associated with Osteoporosis Pseudoglioma Syndrome. This aids in accurate diagnosis, differentiation from other bone or eye disorders, risk assessment for family members, and personalized management strategies.
How to Prepare
- Ensure patient identification and consent
- Use appropriate collection tubes for blood or saliva
- Label samples correctly with patient details
- Transport samples to the lab within specified stability period
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This NGS test is essential for confirming OPPG diagnosis, guiding management, and genetic counseling for affected families."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood samples
- Insufficient sample volume
- Improperly labeled or contaminated samples
- Samples exceeding stability period
Understanding Your Results
Positive for pathogenic variant
Confirms diagnosis of Osteoporosis Pseudoglioma Syndrome; genetic counseling and management recommended.
Negative for pathogenic variant
No mutations detected in LRP5 gene; consider other genetic or clinical causes for symptoms.
Variant of uncertain significance (VUS)
Further testing or family studies may be needed; consult a geneticist for guidance.
Consult a healthcare professional if symptoms such as frequent fractures, vision problems, or low bone density persist, or if there is a family history of OPPG. Genetic counseling is advised before and after testing.
Limitations
- ⚠May not detect all types of genetic variants, such as large deletions or duplications
- ⚠Variants of uncertain significance (VUS) may be identified
- ⚠Test results should be correlated with clinical findings
- ⚠Does not rule out other genetic causes of similar symptoms
Risks & Considerations
- ●Minimal physical risks from blood draw, such as bruising or infection
- ●Psychological impact of genetic results, including anxiety or distress
- ●Potential for incidental findings unrelated to OPPG
Interfering Factors
- ●Sample contamination
- ●Degraded DNA quality
- ●Hemolyzed blood samples
- ●Insufficient sample volume
Frequently Asked Questions
What is Osteoporosis Pseudoglioma Syndrome (OPPG)?
What are the symptoms of OPPG?
How is OPPG diagnosed?
What is the cost of the LRP5 Gene OPPG NGS Genetic Test in India?
Is the test covered by insurance?
What sample types are accepted for the test?
How long does it take to get results?
Is home sample collection available?
What does a positive test result mean?
Can the test detect all mutations in the LRP5 gene?
What should I do before getting tested?
Are there any risks associated with the test?
Related Tests
WISP3 Gene Arthropathy, progressive pseudorheumatoid, of childhood NGS Genetic Test
₹20,000FLNB Gene Atelosteogenesis type 3 NGS Genetic Test
₹20,000FLNB Gene Atelosteogenesis type 1 NGS Genetic Test
₹20,000EBP Gene Chondrodysplasia punctata, X-linked dominant NGS Genetic Test
₹20,000COL11A1 Gene Marshall syndrome NGS Genetic Test
₹20,000ACTN3 (Sports Gene) Genotyping Test
₹7,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
Book Your Test
Enter your details and we'll connect you within 15 minutes.