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MYH11 Gene Aortic aneurysm, familial thoracic type 4 NGS Genetic Test

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MYH11 Gene Aortic aneurysm, familial thoracic type 4 NGS Genetic Test

Short Name: MYH11 Gene Test

Also known as: Familial thoracic aortic aneurysm and dissection (FTAAD) type 4, MYH11-related aortic aneurysm

MYH11 Gene Aortic aneurysm, familial thoracic type 4 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To detect mutations in the MYH11 gene for early diagnosis, risk assessment, and management of familial thoracic aortic aneurysm type 4, aiding in preventive healthcare and family planning.

Test Code
2551
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Provide clinical history and undergo genetic counseling to draw a pedigree chart of affected family members.

Method: Blood draw or FTA card collection

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or one drop on FTA card by a trained phlebotomist.

Step 3

Report Delivery

Sample processed for NGS analysis; results available in 3-4 weeks.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling session to discuss family history, risks, and benefits of testing.
2
During the Test:Sample collection via blood draw or FTA card; minimal discomfort.
3
After the Test:Results reviewed by geneticist; follow-up counseling and medical management as needed.

About This Test

Who Should Get This Test

To detect mutations in the MYH11 gene for early diagnosis, risk assessment, and management of familial thoracic aortic aneurysm type 4, aiding in preventive healthcare and family planning.

How to Prepare

  • Fast for not required
  • Bring identification and prescription
  • Inform about any medications

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Early genetic testing for MYH11 mutations can aid in timely surveillance and management of familial thoracic aortic aneurysms, potentially preventing life-threatening complications."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodBlood draw or FTA card collection

Sample Stability

Room temperatureUp to 7 days for FTA card
RefrigeratedUp to 5 days for blood
Sample Rejection Criteria:
  • Hemolyzed sample
  • Incorrect labeling
  • Insufficient volume

Understanding Your Results

Results indicate the presence or absence of pathogenic MYH11 mutations. Positive results suggest increased risk for familial thoracic aortic aneurysm type 4.
📊

Pathogenic variant detected

High risk for FTAAD type 4; recommend clinical evaluation and regular monitoring.

📊

Likely pathogenic variant detected

Probable risk; genetic counseling and further testing advised.

📊

Variant of uncertain significance

Clinical correlation needed; may require family studies.

📊

No pathogenic variant detected

Low genetic risk, but clinical symptoms should be evaluated.

⚠️ When to Consult a Doctor:

If symptoms like chest pain or back pain occur, or if there is a family history of aortic aneurysms, consult a healthcare provider immediately for evaluation and possible genetic testing.

Limitations

  • ⚠May not detect all rare variants
  • ⚠Results require clinical correlation
  • ⚠Genetic counseling recommended for interpretation

Risks & Considerations

  • ●Minimal physical risk from blood draw
  • ●Potential psychological impact of results
  • ●Risk of misinterpretation without counseling

Interfering Factors

  • ●Poor sample quality
  • ●Contamination during collection
  • ●Insufficient DNA quantity

Compare With Similar Tests

TestMYH11 Gene Aortic aneurysm, familial thoracic type 4 NGS Genetic TestTGFBR1 Gene TestACTA2 Gene TestSMAD3 Gene TestFBN1 Gene Test
ComparisonMYH11 Gene Aortic aneurysm, familial thoracic type 4 NGS Genetic TestTests for another gene linked to aortic aneurysms; may be recommended based on clinical suspicion.Detects mutations in smooth muscle actin gene; relevant for familial thoracic aortic aneurysms.Associated with arterial aneurysms; part of comprehensive genetic panels.For Marfan syndrome, which can cause aortic dilation; differential diagnosis tool.

Frequently Asked Questions

What is the MYH11 gene?
The MYH11 gene encodes a protein involved in smooth muscle cell function; mutations can lead to familial thoracic aortic aneurysm type 4.
What are the symptoms of MYH11 gene aortic aneurysm?
Symptoms may include chest pain, back pain, shortness of breath, coughing, hoarseness, or difficulty swallowing, but often none until rupture.
How is MYH11 gene aortic aneurysm diagnosed?
Diagnosis involves medical history, physical exam, imaging tests (CT, MRI, echocardiogram), and genetic testing for MYH11 mutations.
What is the cost of NGS genetic testing for MYH11 in India?
The cost is INR 20000.0 at DNA Labs India, including sample collection and reporting.
Is home sample collection available?
Yes, free home collection is offered for online bookings across many cities in India.
How long does it take to get results?
Results are typically available in 3 to 4 weeks after sample collection.
What does a positive test result mean?
A positive result indicates a pathogenic MYH11 mutation, increasing risk for familial thoracic aortic aneurysm type 4; clinical evaluation is recommended.
Can this test be used for family planning?
Yes, genetic testing can inform family members about risks and guide reproductive decisions with genetic counseling.
What is the sample type required?
Blood, extracted DNA, or one drop of blood on an FTA card.
Is fasting required before the test?
No, fasting is not required for this genetic test.
Are raw data files provided with the report?
Yes, DNA Labs India provides raw data, FASTQ, and VCF files along with the clinical report for transparency.
What should I do if I have a family history of aortic aneurysm?
Consult a healthcare provider for genetic counseling and consider MYH11 genetic testing for early detection and management.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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