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MYH3 Gene Arthrogryposis, distal, type 2B NGS Genetic Test

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MYH3 Gene Arthrogryposis, distal, type 2B NGS Genetic Test

Short Name: MYH3 Gene Test

Also known as: Distal Arthrogryposis Type 2B, DA2B

MYH3 Gene Arthrogryposis, distal, type 2B NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of this test is to diagnose Arthrogryposis, distal, type 2B by detecting pathogenic mutations in the MYH3 gene using NGS technology, aiding in clinical management and genetic counseling.

Test Code
4845
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

No specific preparation required. Provide clinical history and genetic counseling session.

Method: Venipuncture or FTA Card

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or one drop on FTA card.

Step 3

Report Delivery

Sample sent to laboratory for NGS analysis. Monitor for any discomfort at collection site.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Provide clinical history and undergo genetic counseling. No fasting required.
2
During the Test:Blood sample collection takes a few minutes. Minimal discomfort expected.
3
After the Test:Resume normal activities. Results available in 3-4 weeks via online portal or email.

About This Test

Who Should Get This Test

The purpose of this test is to diagnose Arthrogryposis, distal, type 2B by detecting pathogenic mutations in the MYH3 gene using NGS technology, aiding in clinical management and genetic counseling.

How to Prepare

  • Ensure proper identification of patient
  • Use sterile collection equipment
  • Label samples correctly
  • Transport samples at ambient temperature

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Genetic testing for MYH3 gene mutations is essential for confirming distal arthrogryposis type 2B, guiding treatment plans, and providing family counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture or FTA Card

Sample Stability

Blood: 24 hours at room temperature
Extracted DNA: stable for longer periods
Sample Rejection Criteria:
  • Insufficient sample volume
  • Contaminated or hemolyzed samples
  • Incorrect labeling

Understanding Your Results

Results indicate the presence or absence of mutations in the MYH3 gene. A positive result confirms genetic basis for distal arthrogryposis type 2B.
📊

Positive for pathogenic variant

Confirms diagnosis of distal arthrogryposis type 2B. Genetic counseling recommended.

📊

Negative for pathogenic variant

No mutations detected in MYH3 gene. Clinical evaluation may be needed for other causes.

📊

Variant of uncertain significance

Further testing or family studies may be required for clarification.

⚠️ When to Consult a Doctor:

Consult a doctor if you or your child exhibits symptoms such as joint contractures, muscle weakness, or if there is a family history of arthrogryposis. After receiving test results, seek genetic counseling for interpretation and management.

Limitations

  • ⚠May not detect all genetic variants
  • ⚠Results require clinical correlation
  • ⚠Turnaround time of 3-4 weeks

Risks & Considerations

  • ●Minor bruising at blood draw site
  • ●Rare risk of infection

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA quality

Frequently Asked Questions

What is the MYH3 Gene Arthrogryposis Test?
It is a genetic test that uses NGS technology to detect mutations in the MYH3 gene, which cause distal arthrogryposis type 2B, a disorder characterized by joint contractures and muscle weakness.
Who should consider this test?
Individuals with symptoms like joint stiffness, muscle weakness, clubfoot, or a family history of arthrogryposis should consider this test for accurate diagnosis.
What is the cost of the test in India?
The test costs INR 20,000 at DNA Labs India, with home sample collection available across India.
How is the sample collected?
A blood sample is collected via venipuncture, or one drop of blood can be placed on an FTA card. Home collection is offered.
Is fasting required for this test?
No, fasting is not required for the MYH3 Gene Arthrogryposis Test.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What do the test results mean?
A positive result indicates a mutation in the MYH3 gene, confirming distal arthrogryposis type 2B. A negative result means no pathogenic variants were detected.
Is the test accurate?
Yes, NGS technology is highly accurate for identifying genetic mutations, but results should be interpreted by a healthcare professional.
Can this test be used for prenatal diagnosis?
It may be used in genetic counseling for families, but consult a geneticist for prenatal testing options.
What are the symptoms of distal arthrogryposis type 2B?
Symptoms include joint contractures, muscle weakness, scoliosis, clubfoot, clenched fists, and difficulty with fine motor skills.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across many cities in India.
How do I prepare for the test?
No special preparation is needed. Provide your clinical history and attend a genetic counseling session if recommended.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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