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NR3C2 Gene Hypertension early onset NGS Genetic Test

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NR3C2 Gene Hypertension early onset NGS Genetic Test

Short Name: NR3C2 Hypertension Test

Also known as: Mineralocorticoid Receptor Gene Test, NR3C2 Mutation Analysis

NR3C2 Gene Hypertension early onset NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood, Extracted DNA, or One drop Blood on FTA Card samples. Results in 3-4 weeks from sample receipt. Free home collection in 300+ cities across India.

Next-Generation Sequencing (NGS)🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the NR3C2 gene associated with early onset hypertension for accurate diagnosis, risk assessment, and personalized treatment planning.

Test Code
5328
Price
₹20,000
Sample Type
Blood, Extracted DNA, or One drop Blood on FTA Card
Result Time
3-4 weeks from sample receipt
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation required. Provide detailed clinical and family history. Genetic counseling session recommended to draw a pedigree chart.

Method: Venipuncture or FTA Card application

Step 2

Laboratory Analysis

A trained phlebotomist will collect a blood sample via venipuncture or apply a drop of blood to an FTA card.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Resume normal activities immediately.

Timeline: 3-4 weeks from sample receipt

Patient Instructions

1
Before the Test:Consult with a genetic counselor to discuss family history and test implications. Provide informed consent.
2
During the Test:Sample collection is quick and minimally invasive. Analysis is performed in a certified laboratory using NGS technology.
3
After the Test:Receive the report via online portal, email, or WhatsApp. Discuss results with a healthcare provider for next steps.

About This Test

Who Should Get This Test

To identify mutations in the NR3C2 gene associated with early onset hypertension for accurate diagnosis, risk assessment, and personalized treatment planning.

How to Prepare

  • Ensure proper patient identification and labeling
  • Use sterile equipment and follow aseptic techniques
  • Handle samples carefully to avoid hemolysis or contamination
  • Store samples at ambient room temperature as specified

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early detection of NR3C2 mutations can guide personalized management of hypertension and reduce cardiovascular risks."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood, Extracted DNA, or One drop Blood on FTA Card
Sample VolumeAs per requirement
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or FTA Card application

Sample Stability

Blood samples stable for up to 48 hours at room temperature
Extracted DNA stable for extended periods when stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Improper labeling or documentation
  • Samples not stored at recommended conditions

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the NR3C2 gene, which may be associated with early onset hypertension and related conditions.
Positive result: Pathogenic mutation detected, indicating increased genetic risk for hypertension and related disorders. Clinical correlation and genetic counseling advised.
Negative result: No pathogenic mutations found, reducing genetic risk but not excluding other causes of hypertension.
Variant of uncertain significance (VUS): Genetic change detected with unclear clinical impact. Further testing or family studies may be recommended.
⚠️ When to Consult a Doctor:

Consult a healthcare provider if results are positive, if there are symptoms of hypertension, or for personalized management based on genetic findings.

Limitations

  • ⚠May not detect all possible mutations or variants
  • ⚠Results require correlation with clinical history and symptoms
  • ⚠Genetic counseling is recommended for interpretation
  • ⚠Does not replace routine blood pressure monitoring

Risks & Considerations

  • ●Minor bruising or discomfort at the blood draw site
  • ●Rare risk of infection or fainting
  • ●Emotional impact of genetic results; counseling available

Interfering Factors

  • ●Poor sample quality or degradation
  • ●Contamination during sample collection or processing
  • ●Technical errors in sequencing or analysis

Compare With Similar Tests

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ComparisonNR3C2 Gene Hypertension early onset NGS Genetic Test

Frequently Asked Questions

What is the NR3C2 gene?
The NR3C2 gene encodes the mineralocorticoid receptor, which regulates salt and water balance in the body. Mutations in this gene can lead to early onset hypertension.
Who should consider this genetic test?
Individuals with a family history of hypertension, early onset hypertension (before age 40), resistant hypertension, or suspected genetic causes should consider this test.
How is the test performed?
The test uses Next-Generation Sequencing (NGS) to analyze DNA from a blood sample or extracted DNA for mutations in the NR3C2 gene.
What does a positive result mean?
A positive result indicates a pathogenic mutation in the NR3C2 gene, increasing the risk for early onset hypertension and related conditions. Genetic counseling is recommended.
Is fasting required for this test?
No, fasting is not required. The test involves a simple blood draw or FTA card sample collection.
How long does it take to get results?
Results are typically available within 3-4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across many cities in India.
What is the cost of the test?
The test costs INR 20000.0, with no hidden fees. It includes sample collection, analysis, and report generation.
Can this test diagnose hypertension?
The test detects genetic mutations associated with hypertension but does not diagnose hypertension itself. It should be used alongside clinical evaluation.
Are there any risks involved?
Risks are minimal, similar to a standard blood draw, such as bruising or discomfort. Emotional support is available through genetic counseling.
What if the result is negative?
A negative result means no pathogenic mutations were found in the NR3C2 gene, but it does not rule out other causes of hypertension. Continue regular health monitoring.
How can I prepare for the test?
No special preparation is needed. Provide your clinical and family history, and consider a genetic counseling session before testing.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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