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NTNG1 Gene Autism, NTNG1 Related NGS Genetic Test

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NTNG1 Gene Autism, NTNG1 Related NGS Genetic Test

Short Name: NTNG1 NGS Test

Also known as: NTNG1 Gene Autism Test, NTNG1 Related NGS Genetic Test, NTNG1 Gene Sequencing

NTNG1 Gene Autism, NTNG1 Related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood / Extracted DNA / One drop blood on FTA card samples. Results in NGS processing, bioinformatics analysis, variant interpretation, and report preparation generally take 3 to 4 weeks from the time the sample is received in the laboratory.. Free home collection in 300+ cities across India.

NGS Genetic TestAll age groups🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to detect clinically significant variants in the NTNG1 gene that may be associated with autism spectrum disorder and related neurodevelopmental features. The test supports diagnosis, risk stratification, family screening, and informed genetic counselling.

Test Code
3928
ICD Code
F84.0
Price
₹20,000
Sample Type
Blood / Extracted DNA / One drop blood on FTA card
Result Time
NGS processing, bioinformatics analysis, variant interpretation, and report preparation generally take 3 to 4 weeks from the time the sample is received in the laboratory.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No fasting is required. A referral from a doctor and a pre-test genetic counselling session are recommended. During counselling, a pedigree chart may be drawn to document family members affected by NTNG1-related diseases or neurological disorders.

Method: Peripheral blood draw / dried blood spot / submission of extracted DNA

Step 2

Laboratory Analysis

A small volume of blood will be collected from a vein in the arm. For an FTA card sample, one drop of blood is placed on the card. The procedure is quick and usually painless.

Step 3

Report Delivery

You may return to routine activities immediately. The sample is transported to the laboratory for NGS processing. Reports are generally provided within 3 to 4 weeks.

Timeline: NGS processing, bioinformatics analysis, variant interpretation, and report preparation generally take 3 to 4 weeks from the time the sample is received in the laboratory.

Patient Instructions

1
Before the Test:No special preparation is needed. Fasting is not required. Pre-test genetic counselling is advised to discuss the purpose, benefits, limitations, and possible outcomes of the test.
2
During the Test:The test requires a small blood sample. If a dried blood spot is used, a single drop of blood from a fingertip or heel is collected on an FTA card. The process takes only a few minutes.
3
After the Test:You can continue your regular routine after sample collection. The laboratory will analyse the NTNG1 gene and share the report through your preferred delivery method once available.

About This Test

Who Should Get This Test

The purpose of this test is to detect clinically significant variants in the NTNG1 gene that may be associated with autism spectrum disorder and related neurodevelopmental features. The test supports diagnosis, risk stratification, family screening, and informed genetic counselling.

How to Prepare

  • No fasting required
  • Genetic counselling and informed consent before testing
  • Use EDTA vacutainer for whole blood sample
  • FTA card samples must be air-dried and placed in the provided pouch
  • Extracted DNA samples should be labelled clearly and maintained in chilled conditions during transport

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"When an NTNG1 variant is identified, genetic counselling is helpful to discuss the implications for the patient, family members, and future pregnancy planning."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood / Extracted DNA / One drop blood on FTA card
Sample VolumeAs per laboratory protocol
ContainerEDTA vacutainer / FTA card / sterile DNA tube
Collection MethodPeripheral blood draw / dried blood spot / submission of extracted DNA

Sample Stability

Whole blood: transport to laboratory as soon as possible; avoid extreme temperatures
FTA card: stable at room temperature for several weeks when stored dry
Extracted DNA: stable at -20°C until analysis
Sample Rejection Criteria:
  • Clotted blood sample in an anticoagulant tube
  • Insufficient sample volume
  • Haemolysed specimen
  • Mislabelled sample or unaccompanied by proper consent/referral documents

Understanding Your Results

The clinical report will identify whether a pathogenic, likely pathogenic, benign, or uncertain variant is present in the NTNG1 gene. All results should be discussed with a qualified healthcare provider in the context of the individual's symptoms, developmental history, and family history.
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⚠️ When to Consult a Doctor:

If a pathogenic or likely pathogenic NTNG1 variant is identified, or if you have concerns about autism symptoms in yourself, your child, or a family member, consult a qualified doctor. Clinical geneticists, paediatricians, neurologists, psychiatrists, or an obstetrician-gynaecologist for reproductive counselling can provide personalised guidance.

Limitations

  • ⚠This test targets only the NTNG1 gene and does not exclude other genetic causes of autism.
  • ⚠Standard NGS may not detect all types of variants, such as large copy number changes, repeat expansions, or deep intronic variants.
  • ⚠A variant of uncertain significance (VUS) may be reported; additional family studies or further testing may be needed.
  • ⚠Negative results do not rule out an NTNG1-related disorder or autism and should be interpreted with clinical judgement.
  • ⚠Result interpretation requires the clinical phenotype and family history to be taken into account.

Risks & Considerations

  • ●Minimal pain or bruising at the blood collection site
  • ●Rarely, local swelling or infection at the venipuncture site
  • ●No radiation exposure or major medical risks are associated with this test

Interfering Factors

  • ●Clotted, haemolysed, or contaminated blood samples
  • ●Insufficient DNA quantity or quality
  • ●Genetic mosaicism below the sequencing detection threshold
  • ●Complex structural rearrangements that NGS may not reliably detect
  • ●Sample mix-up or mislabelling

Compare With Similar Tests

TestNTNG1 Gene Autism, NTNG1 Related NGS Genetic TestWhole Exome Sequencing (WES)Autism/Intellectual Disability NGS PanelChromosomal Microarray (CMA)
ComparisonNTNG1 Gene Autism, NTNG1 Related NGS Genetic Test

Frequently Asked Questions

What is the NTNG1 gene?
The NTNG1 gene (Netrin G1) is located on chromosome 1. It provides instructions for a protein important in the nervous system, particularly for synapse formation and maintenance, which are essential for communication between neurons.
Why is NTNG1 tested for autism?
Research has suggested that mutations in NTNG1 may disrupt normal synaptic signalling and increase susceptibility to autism. Testing this gene helps identify clinically relevant variants in people with autism features and supports genetic counselling.
What is the cost of the NTNG1 related NGS genetic test?
The test costs INR 20,000 at DNA Labs India. The price includes sample collection, NGS analysis, clinical interpretation, and genetic counselling. Free home sample collection is available for online bookings.
What sample is required for this test?
Acceptable samples include whole blood in an EDTA vacutainer, extracted DNA, or one drop of blood on an FTA card.
Do I need to fast before the test?
No, fasting is not required for the NTNG1 related NGS genetic test.
How long will the test report take?
Reports are generally available within 3 to 4 weeks after the sample is received at the laboratory.
Does this test rule out all causes of autism?
No. This test only analyses the NTNG1 gene. Autism is genetically diverse, and many other genes and non-genetic factors can contribute. A negative result does not exclude autism.
What are common symptoms of autism that may prompt testing?
Common symptoms include delayed speech and language skills, reduced social interaction, repetitive behaviours, sensory sensitivities, and difficulty with change or transitions. A doctor should be consulted for full evaluation.
Will I receive raw FASTQ/VCF data files?
Yes. DNA Labs India shares raw data, FASTQ and VCF files along with the clinical report for transparency and further analysis.
What is a variant of uncertain significance (VUS)?
A variant of uncertain significance (VUS) is a genetic change whose effect on health is not yet clear. It may require additional family testing, segregation analysis, or functional studies to determine its clinical significance.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across many cities in India, including Delhi, Mumbai, Bangalore, Hyderabad, Chennai, Kolkata, and others.
Who should I consult after receiving the report?
If you receive a positive or uncertain result, consult a clinical geneticist, neurologist, psychiatrist, paediatrician, or obstetrician-gynaecologist for personalised advice. Genetic counselling can help discuss recurrence risk and management options.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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