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PRKAG2 Gene Wolff -Parkinson-White syndrome NGS Genetic Test

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PRKAG2 Gene Wolff -Parkinson-White syndrome NGS Genetic Test

Short Name: PRKAG2 Gene WPW Syndrome NGS Test

Also known as: WPW Syndrome Genetic Test, PRKAG2 Mutation Analysis, Cardiac Genetic Panel

PRKAG2 Gene Wolff -Parkinson-White syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to detect mutations in the PRKAG2 gene associated with Wolff-Parkinson-White syndrome, aiding in definitive diagnosis, risk assessment, genetic counseling, and personalized management of cardiac arrhythmias.

Test Code
5307
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation required. Provide clinical history and family pedigree as advised.

Method: Venipuncture or finger prick

Step 2

Laboratory Analysis

A blood sample will be collected via venipuncture or finger prick. For FTA card, a drop of blood is applied.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bleeding. Store samples as instructed.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Provide detailed clinical history and family pedigree. No fasting required unless specified.
2
During the Test:Sample collection takes a few minutes. The test involves DNA extraction and NGS analysis in the lab.
3
After the Test:Resume normal activities. Monitor for any symptoms and follow up with healthcare provider.

About This Test

Who Should Get This Test

The purpose of this test is to detect mutations in the PRKAG2 gene associated with Wolff-Parkinson-White syndrome, aiding in definitive diagnosis, risk assessment, genetic counseling, and personalized management of cardiac arrhythmias.

How to Prepare

  • Ensure proper identification and labeling of samples
  • Follow aseptic techniques during collection
  • Transport samples at room temperature unless specified

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"As a referring specialist, I recommend this genetic test for patients with suspected Wolff-Parkinson-White syndrome to confirm PRKAG2 mutations, aiding in diagnosis and family planning counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or finger prick

Sample Stability

Blood samples stable for 48 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Insufficient sample volume
  • Improperly labeled or contaminated samples

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the PRKAG2 gene. Positive results confirm genetic predisposition to WPW syndrome, while negative results may require further testing if clinical suspicion remains.
Positive: Pathogenic variant detected - confirms genetic cause, recommend genetic counseling and cardiac evaluation
Negative: No pathogenic variants detected - does not rule out other genetic or non-genetic causes
Variant of uncertain significance (VUS) - requires further investigation and family studies
⚠️ When to Consult a Doctor:

Consult a cardiologist or geneticist if symptoms persist, worsen, or if there is a family history of cardiac disorders. Genetic counseling is recommended for result interpretation.

Limitations

  • ⚠May not detect all genetic variants or mutations in non-coding regions
  • ⚠Requires genetic counseling for interpretation
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minimal risks from blood draw, such as bruising or infection
  • ●Genetic testing may have psychological implications; counseling is advised

Interfering Factors

  • ●Poor sample quality or contamination
  • ●Hemolyzed or degraded DNA samples
  • ●Recent blood transfusions may affect results

Compare With Similar Tests

TestPRKAG2 Gene Wolff -Parkinson-White syndrome NGS Genetic TestElectrocardiogram (ECG)Holter MonitorElectrophysiological Study (EPS)
ComparisonPRKAG2 Gene Wolff -Parkinson-White syndrome NGS Genetic Test

Frequently Asked Questions

What is the PRKAG2 Gene Wolff-Parkinson-White Syndrome NGS Genetic Test?
It is a next-generation sequencing test that detects mutations in the PRKAG2 gene associated with Wolff-Parkinson-White syndrome, a genetic cardiac condition.
Who should consider getting this test?
Individuals with a family history of WPW syndrome, symptoms like palpitations or fainting, or abnormal ECG findings should consider this test.
How is the test performed?
A blood or DNA sample is collected and analyzed using NGS technology to sequence the PRKAG2 gene for mutations.
What is the cost of the test?
The test costs INR 20,000 at DNA Labs India, with free home sample collection across India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities across India.
What are the symptoms of Wolff-Parkinson-White syndrome?
Common symptoms include palpitations, shortness of breath, chest pain, dizziness, and fainting, which may occur during exercise or spontaneously.
How is WPW syndrome diagnosed?
Diagnosis involves medical history, physical exam, and tests like ECG, echocardiogram, Holter monitor, and electrophysiological study, often confirmed by genetic testing.
What does a positive test result mean?
A positive result indicates a pathogenic mutation in the PRKAG2 gene, confirming genetic predisposition to WPW syndrome, and warrants genetic counseling and cardiac evaluation.
What are the risks of the genetic test?
Risks are minimal, primarily related to blood draw, such as bruising. Genetic results may have psychological impacts, so counseling is recommended.
Is genetic counseling provided with the test?
Yes, DNA Labs India includes genetic counseling as part of the test package to help interpret results and discuss implications.
How can I book the test?
You can book online through DNA Labs India's website or contact them via phone or WhatsApp for assistance with sample collection and payment.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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