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PRKCSH Gene Polycystic liver disease NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

PRKCSH Gene Polycystic liver disease NGS Genetic Test

Short Name: PRKCSH PLD NGS Test

Also known as: PRKCSH Gene Test, Polycystic Liver Disease Genetic Test, PLD NGS Test

PRKCSH Gene Polycystic liver disease NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

To diagnose mutations in the PRKCSH gene associated with polycystic liver disease, enabling early detection, risk assessment, and informed management decisions.

Test Code
5485
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation is required. Provide clinical history and family pedigree as advised.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in the arm using standard venipuncture technique.

Step 3

Report Delivery

Apply pressure to the puncture site to stop bleeding. Resume normal activities unless otherwise directed.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Provide clinical history and family pedigree. No fasting required.
2
During the Test:Blood sample collection via venipuncture.
3
After the Test:Sample sent to laboratory for NGS analysis. Await results.

About This Test

Who Should Get This Test

To diagnose mutations in the PRKCSH gene associated with polycystic liver disease, enabling early detection, risk assessment, and informed management decisions.

How to Prepare

  • Ensure proper patient identification
  • Use sterile collection equipment
  • Label samples correctly
  • Transport samples at ambient temperature as per guidelines

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"This test is crucial for early diagnosis and management of polycystic liver disease, especially in individuals with a family history or symptoms. Genetic counseling is recommended post-test."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required
ContainerEDTA tube or FTA card
Collection MethodVenipuncture

Sample Stability

Blood: 24 hours at room temperature
Extracted DNA: Stable for years if stored properly
Sample Rejection Criteria:
  • Insufficient sample volume
  • Incorrect sample container
  • Contaminated or hemolyzed samples

Understanding Your Results

Results indicate the presence or absence of mutations in the PRKCSH gene. Positive results suggest an increased risk of polycystic liver disease, while negative results indicate low risk but do not exclude other causes.
📊

Mutation Detected

Pathogenic variant in PRKCSH gene identified, associated with increased risk of polycystic liver disease. Genetic counseling and clinical follow-up recommended.

📊

No Mutation Detected

No pathogenic variants found in PRKCSH gene. Risk of PLD due to this gene is low, but other genetic or environmental factors may be involved.

📊

Variant of Uncertain Significance

A genetic variant was found but its clinical significance is unknown. Further testing and consultation may be needed.

⚠️ When to Consult a Doctor:

If you experience symptoms of polycystic liver disease, have a family history of the condition, or receive a positive test result, consult a healthcare provider or genetic counselor for personalized advice.

Limitations

  • ⚠May not detect all types of mutations or variants of uncertain significance
  • ⚠Results require interpretation by a qualified geneticist or healthcare provider
  • ⚠Does not rule out other genetic causes of liver disease

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection at puncture site

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Hemolyzed blood samples

Compare With Similar Tests

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ComparisonPRKCSH Gene Polycystic liver disease NGS Genetic Test

Frequently Asked Questions

What is the PRKCSH Gene Polycystic Liver Disease NGS Genetic Test?
It is a genetic test that uses next-generation sequencing to detect mutations in the PRKCSH gene, which is associated with polycystic liver disease.
How much does the test cost?
The test costs INR 20,000 at DNA Labs India, with free home collection available.
What sample is required for the test?
The test requires a blood sample, extracted DNA, or one drop of blood on an FTA card.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Is home collection available?
Yes, free home sample collection is available for online bookings across India.
What are the symptoms of polycystic liver disease?
Symptoms include abdominal pain, bloating, nausea, vomiting, shortness of breath, and jaundice, though many individuals may be asymptomatic.
How is polycystic liver disease diagnosed?
Diagnosis often involves imaging tests like ultrasound, CT scan, or MRI, along with genetic testing for confirmation.
What is the role of the PRKCSH gene in PLD?
The PRKCSH gene encodes hepatocystin, a protein involved in bile duct formation. Mutations can lead to cyst development in the liver.
Is the test covered by insurance?
Coverage varies by insurance plan. It is not typically covered under government schemes like PMJAY or CGHS; check with your provider.
What should I do if I have a family history of PLD?
Consider genetic testing and consult a healthcare provider or genetic counselor for risk assessment and management.
How accurate is the NGS genetic test?
NGS is highly accurate for detecting known mutations, but results should be interpreted by a genetic specialist.
What are the risks of the test?
The test involves minimal risks from blood draw, such as bruising or infection, which are rare.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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