PROS1 Gene Protein S Deficiency, autosomal dominant NGS Genetic Test
Short Name: PROS1 Protein S Deficiency Test
Also known as: Protein S Deficiency Genetic Test, PROS1 Mutation Analysis, Hereditary Thrombophilia Test
PROS1 Gene Protein S Deficiency, autosomal dominant NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS), Sanger Confirmation on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To diagnose PROS1 gene mutations causing protein S deficiency, assess thrombosis risk, guide treatment decisions, and enable family screening for autosomal dominant inheritance.
- Test Code
- 5343
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS), Sanger Confirmation
Sample Collection
No special preparation required. Provide clinical history and family pedigree.
Method: Venipuncture or finger-prick
Laboratory Analysis
Blood sample drawn via venipuncture or finger-prick onto FTA card.
Report Delivery
Apply pressure to puncture site. Store sample at ambient temperature.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
To diagnose PROS1 gene mutations causing protein S deficiency, assess thrombosis risk, guide treatment decisions, and enable family screening for autosomal dominant inheritance.
How to Prepare
- Ensure proper labeling
- Avoid contamination
- Transport sample within stability period
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This test is crucial for families with a history of thrombosis or recurrent pregnancy loss, enabling early intervention and personalized care."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient sample volume
- Hemolyzed or clotted sample
- Incorrect labeling
Understanding Your Results
Pathogenic variant detected
Confirms diagnosis; increased thrombosis risk. Consult hematologist for management.
No pathogenic variant detected
Reduces likelihood of genetic deficiency; consider other causes if symptoms persist.
Variant of uncertain significance (VUS)
Further testing or family studies may be needed. Genetic counseling recommended.
If you have a family history of thrombosis, recurrent clots, or unexplained pregnancy losses, consult a hematologist or genetic counselor.
Limitations
- ⚠May not detect all genetic variants
- ⚠Results require clinical correlation
- ⚠Does not measure protein S levels directly
Risks & Considerations
- ●Minor bruising at puncture site
- ●Rare infection risk
- ●Psychological impact of genetic results
Interfering Factors
- ●Recent blood transfusion
- ●Anticoagulant therapy
- ●Sample hemolysis
Frequently Asked Questions
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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