PRX Gene Dejerine-Sottas disease NGS Genetic Test
Short Name: PRX NGS Genetic Test
Also known as: PRX gene sequencing, Dejerine-Sottas disease genetic test, Periaxin gene NGS test
PRX Gene Dejerine-Sottas disease NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are typically available within 3 to 4 weeks after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To confirm a clinical diagnosis of Dejerine-Sottas disease by identifying pathogenic variants in the PRX gene using next-generation sequencing.
- Test Code
- 4003
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are typically available within 3 to 4 weeks after sample receipt.
- Fasting Required
- No
- Method
- NGS Technology
Sample Collection
No special preparation or fasting is required. Please carry your doctor’s prescription, clinical history, and any previous test reports. A formal genetic counselling session and pedigree chart are recommended before testing.
Method: Blood draw / FTA card sample collection
Laboratory Analysis
A simple blood sample is collected by a trained phlebotomist. If using FTA card, one drop of blood is applied to the designated card.
Report Delivery
No specific precautions are needed after sample collection. You may resume normal activities immediately.
Timeline: Reports are typically available within 3 to 4 weeks after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
To confirm a clinical diagnosis of Dejerine-Sottas disease by identifying pathogenic variants in the PRX gene using next-generation sequencing.
How to Prepare
- Blood: Collected in an EDTA vacutainer
- Extracted DNA: Provide in a clearly labelled tube
- FTA Card: Apply one drop of blood on the FTA card and allow to air dry
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"A molecular confirmation is essential to distinguish Dejerine-Sottas disease from other inherited neuropathies. Genetic counselling before and after testing helps families understand recurrence risk and clinical consequences."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Improperly labelled sample
- Haemolysed or clotted blood sample
- Insufficient sample volume
- Sample received in improper container
- Missing clinical information or requisition form
Understanding Your Results
Consistent with a diagnosis of Dejerine-Sottas disease. Clinical correlation and familial testing recommended.
No PRX gene mutation was found. Consider other hereditary neuropathy genes if clinical suspicion persists.
A DNA change was found whose clinical significance is unknown. Family studies and additional tests may be needed.
Not associated with the disease and does not explain the clinical presentation.
If your child or adolescent has progressive muscle weakness, sensory loss, balance difficulties, or loss of reflexes, you should consult a neurologist or a clinical geneticist for evaluation and genetic testing.
Limitations
- ⚠This test detects mutations in the PRX gene only and not other causes of inherited neuropathies
- ⚠NGS may not detect large deletions/duplications without complementary analysis
- ⚠Variants of uncertain significance may require familial testing and additional evaluation
- ⚠A negative result does not completely exclude DSD if clinical suspicion remains high
Risks & Considerations
- ●Bruising or bleeding at the blood draw site
- ●Infection (rare)
- ●Psychological distress from genetic result
- ●Genetic discrimination concerns (limited by law)
Interfering Factors
- ●Low-quality or degraded DNA sample
- ●Incomplete clinical information
- ●Sample mix-up or improper labelling
- ●NGS limitations for certain structural rearrangements or large copy number changes
Compare With Similar Tests
| Test | PRX Gene Dejerine-Sottas disease NGS Genetic Test | PRX Gene NGS Test | PMP22 Gene Analysis | CMT/Hereditary Neuropathy NGS Panel | Nerve Conduction Velocity (NCV) Test |
|---|---|---|---|---|---|
| Comparison | PRX Gene Dejerine-Sottas disease NGS Genetic Test |
Frequently Asked Questions
What is the PRX gene Dejerine-Sottas disease NGS genetic test?
Who should undergo this test?
What sample is required for this test?
Is fasting required for the PRX gene NGS genetic test?
What is the cost of the PRX gene Dejerine-Sottas disease NGS genetic test?
How will I receive my test results?
What do the raw data files include?
Is home sample collection available?
Can this test confirm Dejerine-Sottas disease?
Can treatment be started based on the test result?
Does a negative PRX test exclude Dejerine-Sottas disease?
Why is genetic counselling important before this test?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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