Quadruple Marker Test
Also known as: Quad Marker Test, Quadruple Screen
Quadruple Marker Test test available at DNA Labs India for ₹4,500. Uses Chemiluminescent Immunoassay on Serum samples. Results in 3-4 days. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The primary purpose of the Quadruple Marker Test is to screen for potential fetal abnormalities, including Down syndrome, trisomy 18, and neural tube defects, by measuring specific biomarkers in the mother's blood during the second trimester of pregnancy.
- Test Code
- 3176
- Price
- ₹4,500
- Sample Type
- Serum
- Result Time
- 3-4 days
- Fasting Required
- No
- Method
- Chemiluminescent Immunoassay
Sample Collection
No special preparation is required. Inform your healthcare provider about any medications or supplements you are taking.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn from a vein in your arm by a trained phlebotomist. The process is quick and minimally invasive.
Report Delivery
Apply pressure to the puncture site to stop bleeding. You can resume normal activities immediately. Mild bruising may occur.
Timeline: 3-4 days
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the Quadruple Marker Test is to screen for potential fetal abnormalities, including Down syndrome, trisomy 18, and neural tube defects, by measuring specific biomarkers in the mother's blood during the second trimester of pregnancy.
How to Prepare
- Wear loose-fitting clothing for easy access to your arm
- Stay hydrated before the test
- Inform the collector about any bleeding disorders or allergies
- Bring a doctor's prescription if required, though not mandatory for pregnancy cases
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"The Quadruple Marker Test is a vital screening tool in prenatal care, aiding in the early detection of fetal abnormalities such as Down syndrome and neural tube defects. It is often recommended by healthcare providers to assess fetal health during the second trimester."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or lipemic samples
- Insufficient sample volume
- Incorrect labeling or identification
- Sample collected in wrong container
Understanding Your Results
Normal levels
Low risk for screened abnormalities; continue routine prenatal care.
Elevated AFP
May indicate neural tube defects or other issues; further evaluation recommended.
Abnormal HCG or uE3
Could suggest chromosomal abnormalities like Down syndrome; consult a specialist.
High Inhibin A
Associated with increased risk of Down syndrome; additional testing may be advised.
Consult your doctor if results are abnormal, if you have a family history of genetic disorders, or if you experience any unusual symptoms during pregnancy. Always discuss results with a healthcare provider for personalized advice.
Limitations
- ⚠This is a screening test, not diagnostic; false positives or negatives may occur
- ⚠Results are influenced by gestational age and maternal factors
- ⚠Does not detect all fetal abnormalities
- ⚠May require follow-up with invasive tests like amniocentesis for confirmation
Risks & Considerations
- ●Minimal risks such as bruising, swelling, or dizziness at the blood draw site
- ●Very rare risk of infection or excessive bleeding
Interfering Factors
- ●Multiple pregnancies (e.g., twins)
- ●Gestational diabetes
- ●Maternal weight or BMI variations
- ●Incorrect gestational age dating
- ●Certain medications or supplements
- ●Smoking or substance use during pregnancy
Compare With Similar Tests
| Test | Quadruple Marker | Triple Marker Test | Non-Invasive Prenatal Testing (NIPT) | Amniocentesis | Chorionic Villus Sampling (CVS) | Ultrasound |
|---|---|---|---|---|---|---|
| Comparison | Quadruple Marker | Measures three markers (AFP, HCG, uE3) instead of four; less comprehensive than quadruple marker. | Analyzes fetal DNA in maternal blood; higher accuracy for chromosomal abnormalities but more expensive. | Invasive diagnostic test with higher accuracy but carries risks like miscarriage. | Invasive test performed earlier in pregnancy; diagnostic but with potential risks. | Imaging test often used alongside blood screening for comprehensive fetal assessment. |
Frequently Asked Questions
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