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SCN5A Gene Heart block, progressive, familial, type 1A NGS Genetic Test

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SCN5A Gene Heart block, progressive, familial, type 1A NGS Genetic Test

Also known as: Familial Heart Block Type 1A, SCN5A Cardiac Conduction Disease

SCN5A Gene Heart block, progressive, familial, type 1A NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood, Extracted DNA, or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To confirm the diagnosis of SCN5A gene-related progressive familial heart block type 1A through identification of pathogenic genetic variants, aiding in clinical management and family screening.

Test Code
5256
Price
₹20,000
Sample Type
Blood, Extracted DNA, or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Genetic counseling session recommended to discuss test implications and draw a pedigree chart of affected family members.

Method: Venipuncture or Home Collection

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or home collection using FTA card.

Step 3

Report Delivery

Apply pressure to the puncture site to stop bleeding; store sample as per instructions.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling to discuss test purpose, implications, and family history.
2
During the Test:DNA extraction and NGS analysis of the SCN5A gene for variant detection.
3
After the Test:Report generation and genetic counseling to interpret results and plan next steps.

About This Test

Who Should Get This Test

To confirm the diagnosis of SCN5A gene-related progressive familial heart block type 1A through identification of pathogenic genetic variants, aiding in clinical management and family screening.

How to Prepare

  • Ensure proper sample labeling with patient details
  • Avoid hemolysis during blood collection
  • Use sterile equipment and follow aseptic techniques

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Genetic testing for SCN5A mutations is essential for early diagnosis and management of familial heart block, helping to prevent complications like arrhythmias."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood, Extracted DNA, or One drop Blood on FTA Card
Collection MethodVenipuncture or Home Collection

Sample Stability

Blood samples stable for 24 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Insufficient sample volume
  • Improper labeling or container

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the SCN5A gene, which are associated with progressive familial heart block type 1A.
Positive: Pathogenic variant detected, confirming diagnosis and requiring clinical management
Negative: No pathogenic variant detected, but clinical correlation is advised
Variant of Uncertain Significance (VUS): Further testing or family studies may be needed
⚠️ When to Consult a Doctor:

Consult a cardiologist or genetic specialist immediately if test is positive or if symptoms persist, for appropriate management and family screening.

Limitations

  • ⚠May not detect all genetic variants or mutations
  • ⚠Results require interpretation by a genetic specialist
  • ⚠Does not rule out other cardiac conditions

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Potential for uncertain results requiring further evaluation
  • ●Psychological impact of genetic diagnosis

Interfering Factors

  • ●Poor sample quality or contamination
  • ●Hemolyzed blood samples
  • ●Insufficient DNA quantity

Frequently Asked Questions

What is SCN5A Gene Heart Block?
SCN5A Gene Heart Block is a rare genetic condition caused by mutations in the SCN5A gene, affecting the heart's electrical system and leading to progressive conduction disorders.
What are the symptoms of SCN5A Gene Heart Block?
Symptoms may include fainting, dizziness, shortness of breath, palpitations, and chest pain, though some individuals may have no symptoms.
How is SCN5A Gene Heart Block diagnosed?
Diagnosis involves medical history, physical exam, ECG, Holter monitoring, and genetic testing to confirm SCN5A mutations.
What is NGS Genetic Testing?
NGS (Next-Generation Sequencing) Genetic Testing is a advanced method to analyze DNA and identify specific genetic mutations accurately.
What is the cost of the SCN5A Gene Heart Block NGS Genetic Test?
The cost is INR 20000.0 at DNA Labs India, with home sample collection available across India.
Is the test covered by insurance?
NGS Genetic Testing may not be covered by insurance; out-of-pocket costs are common, but financing options may be available.
How long does it take to get the results?
Results are typically available within 3 to 4 weeks after sample collection.
What sample is required for the test?
The test requires blood, extracted DNA, or one drop of blood on an FTA card.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test in many cities across India.
What should I do if the test is positive?
If positive, consult a cardiologist for management options, which may include medication or pacemaker implantation, and consider genetic counseling for family members.
Can this test be done for children?
Yes, the test can be performed on individuals of all ages, but genetic counseling is recommended for pediatric cases.
How accurate is the NGS Genetic Test?
NGS Genetic Testing is highly accurate for detecting pathogenic variants in the SCN5A gene, but results should be interpreted by a genetic specialist.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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