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SCN9A Gene Insensitivity to pain, channelopathy-associated NGS Genetic Test

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SCN9A Gene Insensitivity to pain, channelopathy-associated NGS Genetic Test

Short Name: SCN9A NGS Test

Also known as: SCN9A Congenital Insensitivity to Pain Test, SCN9A Pain Insensitivity NGS Panel, Channelopathy-Associated NGS Genetic Test

SCN9A Gene Insensitivity to pain, channelopathy-associated NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are typically issued within 3 to 4 weeks from the date the sample reaches the laboratory.. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this NGS genetic test is to identify pathogenic variants in the SCN9A gene associated with insensitivity to pain and channelopathy-associated pain disorders. It aids in confirming the diagnosis, assessing hereditary risk, and guiding family screening and genetic counselling.

Test Code
4153
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Reports are typically issued within 3 to 4 weeks from the date the sample reaches the laboratory.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation is required. Fasting is not needed. Please carry a valid prescription or clinical referral if available. A genetic counselling session is recommended before the test to record the family history and draw a pedigree chart.

Method: Peripheral vein blood draw or FTA card spot

Step 2

Laboratory Analysis

A small blood sample will be collected from a vein in the arm by a trained phlebotomist. If an FTA card is used, a few drops of blood will be applied to the card and allowed to dry.

Step 3

Report Delivery

You can resume normal activities immediately. The sample will be labelled and transported to the DNA Labs India laboratory for processing.

Timeline: Reports are typically issued within 3 to 4 weeks from the date the sample reaches the laboratory.

Patient Instructions

1
Before the Test:Discuss your symptoms and family history with a physician or geneticist. Genetic counselling before the test helps understand the implications of the result.
2
During the Test:A clinician or phlebotomist will collect the required blood sample or FTA card spot. No anaesthesia is needed.
3
After the Test:The laboratory will perform DNA extraction, NGS library preparation, sequencing, and bioinformatics analysis. Results will be shared once the clinical report is ready.

About This Test

Who Should Get This Test

The purpose of this NGS genetic test is to identify pathogenic variants in the SCN9A gene associated with insensitivity to pain and channelopathy-associated pain disorders. It aids in confirming the diagnosis, assessing hereditary risk, and guiding family screening and genetic counselling.

How to Prepare

  • Submit the completed test request form and consent document.
  • Provide a clinical history and family pedigree chart before sample collection.
  • For FTA cards, let the blood spot air-dry completely before sealing in the zipper pouch.
  • Maintain appropriate transport conditions as advised by the laboratory.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"As a clinician, I recommend this test when clinical signs of reduced pain sensitivity or a family history of channelopathy-associated pain disorders are present. Early molecular confirmation may help prevent silent injuries and guide genetic counselling. Obstetricians and gynaecologists may also consider this test for family-planning discussions when a parent is known to carry a pathogenic SCN9A variant."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
ContainerEDTA tube / FTA Card / DNA vial
Collection MethodPeripheral vein blood draw or FTA card spot

Sample Stability

Whole blood in EDTA: ship within 72 hours at ambient temperature
FTA card: store dry at room temperature until shipment
Extracted DNA: store at 2-8°C for short term and -20°C for long term
Sample Rejection Criteria:
  • Mislabelled sample
  • Clotted blood sample
  • Insufficient quantity of sample
  • Sample received in an inappropriate container
  • FTA card with insufficient blood spots

Understanding Your Results

The SCN9A NGS genetic test report must be interpreted by a qualified clinical geneticist. Variants are classified according to established international guidelines and correlated with clinical findings and family history.
📊

Confirms molecular diagnosis of SCN9A-related pain insensitivity or channelopathy.

Action: Genetic counselling and targeted family screening are recommended.

📊

SCN9A-associated cause is not identified in this sample.

Action: Other genetic and non-genetic causes should be considered by the treating physician.

📊

Insufficient evidence exists to determine whether the variant is disease-causing.

Action: Family segregation studies and additional clinical correlation may be required.

⚠️ When to Consult a Doctor:

Consult a clinical geneticist, neurologist, or obstetrician-gynaecologist if you notice reduced pain perception, recurrent painless injuries, temperature insensitivity, or if a first-degree relative has been diagnosed with SCN9A-related pain insensitivity. A genetic test may be recommended during family planning or prenatal counselling.

Limitations

  • ⚠This test only analyses SCN9A and does not rule out other pain insensitivity genes.
  • ⚠NGS may not detect all mutation types such as deep intronic mutations or large structural rearrangements.
  • ⚠Variants of uncertain significance (VUS) may be reported and require further investigation.
  • ⚠Clinical correlation with symptoms and family history is essential for accurate interpretation.

Risks & Considerations

  • ●No significant clinical risk is associated with this DNA test.
  • ●Minor bruising, discomfort, or bleeding at the blood collection site may occur.

Interfering Factors

  • ●Contaminated or degraded DNA sample
  • ●Sample mix-up or mislabelling
  • ●Variants present in deep intronic regions not covered by standard NGS assay
  • ●Large deletions or duplications that may require additional copy-number analysis

Compare With Similar Tests

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Frequently Asked Questions

What is the SCN9A gene insensitivity to pain NGS genetic test?
It is a next-generation sequencing test that looks for mutations in the SCN9A gene. These mutations are associated with congenital insensitivity to pain and channelopathy-related pain disorders.
What are the symptoms of SCN9A-related pain insensitivity?
Symptoms may include a reduced response to painful stimuli, delayed pain after injury, numbness or tingling, difficulty sensing heat or cold, and an increased risk of burns, bruises and fractures.
Why is NGS used for this test?
NGS allows comprehensive sequencing of the SCN9A gene in a single assay, detecting single-nucleotide variants and small insertions/deletions across the coding region.
What type of sample is needed?
The test can be performed on whole blood, extracted DNA, or one drop of blood on an FTA card.
Is fasting required before the test?
No, this is a DNA-based test and fasting is not required.
How long does it take to get the report?
Reports are usually delivered within 3 to 4 weeks after the sample reaches the laboratory.
What is the cost of this test?
The SCN9A gene insensitivity to pain NGS genetic test costs INR 20,000 at DNA Labs India.
Does DNA Labs India provide raw data along with the clinical report?
Yes. DNA Labs India is transparent and shares raw data, FASTQ and VCF files along with the conclusive clinical report.
Can this test help with family planning decisions?
It can help. If a pathogenic SCN9A variant is identified, genetic counselling and targeted variant testing for family members can be arranged to assess recurrence risk.
Is the test covered by insurance?
This test is generally not covered by insurance and is usually paid out-of-pocket. Some patients may treat it as a tax-deductible medical expense.
Are there any risks from the test?
The test itself has no clinical risk. Only minor discomfort or bruising at the blood collection site may occur.
Who should consider this test?
Individuals with unexplained reduced sensitivity to pain, recurrent painless injuries, heat/cold sensation problems, or a family history of SCN9A-related pain insensitivity should consider this test after clinical evaluation.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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