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SLCO1B3 Gene Hyperbilirubinemia, Rotor type NGS Genetic Test

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SLCO1B3 Gene Hyperbilirubinemia, Rotor type NGS Genetic Test

Short Name: Rotor Type Hyperbilirubinemia NGS Test

Also known as: Rotor Type Hyperbilirubinemia, SLCO1B3 Gene Disorder

SLCO1B3 Gene Hyperbilirubinemia, Rotor type NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To diagnose Rotor type hyperbilirubinemia by identifying pathogenic mutations in the SLCO1B3 gene using Next-Generation Sequencing (NGS) technology, enabling accurate clinical management and genetic counseling.

Test Code
5426
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Provide clinical history and undergo genetic counseling to draw a pedigree chart of affected family members.

Step 2

Laboratory Analysis

A blood sample will be collected via venipuncture or a drop of blood on an FTA card.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Resume normal activities unless advised otherwise.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Provide clinical history and undergo genetic counseling. No fasting required.
2
During the Test:Blood sample collection via venipuncture or FTA card.
3
After the Test:Monitor the puncture site for any discomfort. Await results in 3 to 4 weeks.

About This Test

Who Should Get This Test

To diagnose Rotor type hyperbilirubinemia by identifying pathogenic mutations in the SLCO1B3 gene using Next-Generation Sequencing (NGS) technology, enabling accurate clinical management and genetic counseling.

How to Prepare

  • Ensure proper identification and labeling of samples
  • Follow aseptic techniques during collection
  • Transport samples at ambient room temperature

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Genetic testing for SLCO1B3 gene mutations is essential for confirming Rotor type hyperbilirubinemia, enabling accurate diagnosis and personalized management to prevent complications."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Rejection Criteria:
  • Hemolyzed or contaminated samples
  • Insufficient sample volume
  • Improperly labeled samples

Understanding Your Results

Results indicate the presence or absence of mutations in the SLCO1B3 gene associated with Rotor type hyperbilirubinemia.
📊

No pathogenic variants detected

Negative for SLCO1B3 gene mutations; consider other causes of hyperbilirubinemia.

📊

Pathogenic variant detected

Confirms diagnosis of Rotor type hyperbilirubinemia; genetic counseling and management recommended.

⚠️ When to Consult a Doctor:

Consult a doctor if symptoms persist, worsen, or if there is a family history of hyperbilirubinemia. Genetic counseling is advised for result interpretation and family planning.

Limitations

  • ⚠May not detect all rare mutations or variants of uncertain significance
  • ⚠Results require clinical correlation and genetic counseling
  • ⚠Does not rule out other causes of hyperbilirubinemia

Risks & Considerations

  • ●Minimal risk from blood draw, such as slight pain, bruising, or infection

Interfering Factors

  • ●Sample contamination
  • ●Improper sample storage
  • ●Recent blood transfusions

Frequently Asked Questions

What is Rotor type hyperbilirubinemia?
Rotor type hyperbilirubinemia is a rare genetic disorder caused by mutations in the SLCO1B3 gene, leading to impaired bilirubin processing in the liver and resulting in jaundice and other symptoms.
What causes Rotor type hyperbilirubinemia?
It is caused by mutations in the SLCO1B3 gene, which is responsible for bilirubin transport in the liver. These mutations are inherited in an autosomal recessive pattern.
What are the symptoms of Rotor type hyperbilirubinemia?
Common symptoms include jaundice (yellowing of skin and eyes), dark urine, light-colored stools, abdominal pain, and fatigue. Symptoms may worsen during stress, illness, or fasting.
How is Rotor type hyperbilirubinemia diagnosed?
Diagnosis involves clinical evaluation, liver function tests showing elevated bilirubin, and confirmatory genetic testing using NGS to detect SLCO1B3 gene mutations.
What is NGS genetic testing?
Next-Generation Sequencing (NGS) is a advanced DNA sequencing technology that accurately detects mutations in genes, such as SLCO1B3, for diagnosing genetic disorders like Rotor type hyperbilirubinemia.
How accurate is the SLCO1B3 gene test?
NGS genetic testing is highly accurate for detecting pathogenic mutations in the SLCO1B3 gene, providing reliable diagnosis when performed in accredited laboratories.
What is the cost of the test in India?
The cost of the SLCO1B3 Gene Hyperbilirubinemia NGS Genetic Test at DNA Labs India is INR 20,000, which includes sample collection and analysis.
Is the test covered by insurance?
This test may not be covered by insurance. Patients should check with their insurance provider for coverage details before undergoing testing.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India, including Mumbai, Delhi, Bangalore, and others.
What should I do before the test?
Before the test, provide your clinical history and undergo a genetic counseling session to draw a pedigree chart of family members affected with similar conditions.
What do the test results mean?
Results indicate whether pathogenic mutations in the SLCO1B3 gene are detected. A positive result confirms Rotor type hyperbilirubinemia, while a negative result suggests other causes. Genetic counseling is recommended for interpretation.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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