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SMAD2 Gene Thoracic aortic aneurysm dissection NGS Genetic Test

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SMAD2 Gene Thoracic aortic aneurysm dissection NGS Genetic Test

Also known as: SMAD2 Gene Test, TAAD Genetic Test, Thoracic Aortic Aneurysm Genetic Test

SMAD2 Gene Thoracic aortic aneurysm dissection NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify mutations in the SMAD2 gene associated with thoracic aortic aneurysm dissection, enabling early diagnosis, risk assessment, and personalized treatment planning.

Test Code
5299
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation required. Inform the lab about any medications or medical conditions.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in the arm using sterile equipment.

Step 3

Report Delivery

Apply pressure to the puncture site to stop bleeding. Resume normal activities immediately.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:A genetic counseling session to discuss family history, test implications, and obtain informed consent.
2
During the Test:Blood sample collection followed by DNA extraction and next-generation sequencing in the laboratory.
3
After the Test:Results are analyzed by geneticists, and a detailed report is provided with genetic counseling for interpretation.

About This Test

Who Should Get This Test

The purpose of this test is to identify mutations in the SMAD2 gene associated with thoracic aortic aneurysm dissection, enabling early diagnosis, risk assessment, and personalized treatment planning.

How to Prepare

  • Ensure proper patient identification
  • Use sterile collection tubes
  • Label samples accurately with patient details

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for TAAD is crucial for early detection and management, especially in families with a history of cardiovascular disorders. Consult a specialist for personalized care."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture

Sample Stability

Blood samples stable for 48 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Insufficient sample volume
  • Improper labeling or documentation

Understanding Your Results

Results indicate the presence or absence of mutations in the SMAD2 gene associated with TAAD. Interpretation should be done by a genetic specialist.
Positive result: Mutation detected, indicating increased risk for TAAD, recommend further clinical evaluation
Negative result: No mutation detected, but symptoms may require other diagnostic tests
Variant of uncertain significance: May need additional testing or family studies for clarification
⚠️ When to Consult a Doctor:

Consult a cardiologist or genetic specialist immediately if you have a family history of TAAD, experience symptoms like sudden chest pain, or if genetic testing reveals a mutation.

Limitations

  • ⚠May not detect all genetic variants
  • ⚠Results require clinical correlation
  • ⚠Not a standalone diagnostic tool

Risks & Considerations

  • ●Minor bruising or pain at the blood draw site
  • ●Rare risk of infection or hematoma

Interfering Factors

  • ●Poor sample quality
  • ●Contaminated DNA
  • ●Technical errors in sequencing

Frequently Asked Questions

What is the SMAD2 Gene TAAD NGS Genetic Test?
It is a genetic test that uses next-generation sequencing to detect mutations in the SMAD2 gene associated with thoracic aortic aneurysm dissection (TAAD).
Who should consider taking this test?
Individuals with a family history of TAAD, symptoms like chest or back pain, or those diagnosed with connective tissue disorders should consider this test.
What is the cost of the test?
The test costs INR 20,000, which includes sample collection, DNA sequencing, and genetic counseling.
How is the test performed?
A blood sample is collected, DNA is extracted, and next-generation sequencing is used to analyze the SMAD2 gene for mutations.
What samples are required for the test?
Blood, extracted DNA, or one drop of blood on an FTA card can be used.
Is fasting required before the test?
No, fasting is not required for this genetic test.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What do the results mean?
A positive result indicates a mutation in the SMAD2 gene, increasing TAAD risk. A negative result means no mutation was detected, but clinical evaluation may still be needed.
Is the test covered by insurance?
Coverage varies by insurance plan. It is not typically covered under government schemes like PMJAY or CGHS; check with your provider.
Can I get home sample collection?
Yes, DNA Labs India offers free home sample collection for online bookings across many cities in India.
What are the risks of the test?
Risks are minimal and include minor bruising at the blood draw site. Serious complications are rare.
How accurate is the test?
The test uses advanced NGS technology for high accuracy, but results should be interpreted by a genetic specialist in clinical context.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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