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STAT1 Gene Atypical Mycobacterial infection NGS Genetic Test

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STAT1 Gene Atypical Mycobacterial infection NGS Genetic Test

Short Name: STAT1 Gene NGS Test

Also known as: STAT1 gene sequencing test, Atypical mycobacterial infection genetic panel, STAT1 NGS diagnostic test

STAT1 Gene Atypical Mycobacterial infection NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify mutations in the STAT1 gene that may increase the risk of atypical mycobacterial infections and related immune disorders. It helps in diagnosing genetic predispositions, guiding treatment decisions, and enabling personalized genetic counseling.

Test Code
2367
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

A detailed clinical history of the patient is required. A genetic counseling session is recommended to draw a pedigree chart of family members affected with STAT1 gene-related conditions.

Method: Venipuncture or FTA card collection

Step 2

Laboratory Analysis

Sample collection is performed via venipuncture for blood samples or by applying one drop of blood on an FTA card. Ensure proper handling and labeling.

Step 3

Report Delivery

The sample is transported to the laboratory under appropriate conditions for DNA extraction and NGS analysis.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling and detailed clinical history are essential before testing. Discuss family history and symptoms with your doctor.
2
During the Test:Sample collection is quick and minimally invasive, typically involving a blood draw or FTA card sampling.
3
After the Test:Results are delivered in 3-4 weeks via online portal, email, or WhatsApp. Follow-up consultation is recommended.

About This Test

Who Should Get This Test

The purpose of this test is to identify mutations in the STAT1 gene that may increase the risk of atypical mycobacterial infections and related immune disorders. It helps in diagnosing genetic predispositions, guiding treatment decisions, and enabling personalized genetic counseling.

How to Prepare

  • Use sterile equipment for blood collection
  • Avoid hemolysis by proper handling
  • Label samples accurately with patient details
  • For FTA cards, allow blood to dry completely before storage

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This test is essential for identifying genetic causes of recurrent infections and guiding personalized management in affected individuals."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or FTA card collection

Sample Stability

Blood samples in EDTA tubes are stable at room temperature for 24 hours
FTA cards with dried blood are stable for long-term storage at room temperature
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Improperly labeled or contaminated samples

Understanding Your Results

Interpretation of results involves analyzing detected genetic variants in the STAT1 gene for their clinical significance. Pathogenic variants indicate an increased risk of atypical mycobacterial infections and related immune disorders.
Detection of pathogenic variants suggests a genetic predisposition to infections and requires medical consultation
Variants of uncertain significance may need further evaluation or family testing
No pathogenic variants detected does not completely rule out other genetic or environmental factors
Consult a genetic counselor for personalized risk assessment and management options
⚠️ When to Consult a Doctor:

If you experience recurrent infections, have a family history of immunodeficiency, or show symptoms like persistent fever and cough, consult a geneticist or immunologist for evaluation.

Limitations

  • ⚠May not detect all possible mutations or variants of uncertain significance
  • ⚠Results require clinical correlation and genetic counseling for interpretation
  • ⚠Limited to STAT1 gene and may not cover other genetic causes of infection susceptibility

Risks & Considerations

  • ●Minor bruising or discomfort at the blood draw site
  • ●Rare risk of infection at collection site
  • ●Emotional impact of genetic results requiring counseling

Interfering Factors

  • ●Sample contamination during collection or handling
  • ●Degraded DNA quality
  • ●Recent blood transfusions affecting DNA analysis

Compare With Similar Tests

TestSTAT1 Gene Atypical Mycobacterial infection NGS Genetic TestIFNGR1 Gene TestIL12RB1 Gene TestMycobacterial Culture
ComparisonSTAT1 Gene Atypical Mycobacterial infection NGS Genetic TestFocuses on interferon-gamma receptor mutations, which also affect mycobacterial susceptibility but through different pathways.Targets interleukin-12 receptor mutations, another genetic cause of impaired immunity to mycobacteria.Traditional method to identify bacterial species, but does not provide genetic insights.

Frequently Asked Questions

What is the STAT1 gene?
The STAT1 gene provides instructions for making a protein that plays a key role in the immune system, helping activate immune cells and trigger interferon production to fight infections.
What are atypical mycobacterial infections?
Atypical mycobacterial infections are caused by nontuberculous mycobacteria found in soil, water, and dust, often affecting individuals with weakened immune systems and causing symptoms like fever and cough.
How do STAT1 gene mutations affect immunity?
Mutations in the STAT1 gene can impair the protein's function, leading to an increased risk of infections, including atypical mycobacterial infections, and may also cause autoimmune disorders.
What symptoms indicate a need for this test?
Symptoms such as persistent respiratory issues, recurrent infections, fever, cough, weight loss, and fatigue, especially in individuals with weakened immune systems, may indicate the need for testing.
How is the test performed?
The test uses next-generation sequencing (NGS) to analyze the STAT1 gene from a blood sample or extracted DNA, identifying genetic mutations that may impact immune function.
What is the cost of the test?
The cost of the STAT1 Gene Atypical Mycobacterial Infection NGS Genetic Test is INR 20,000 in India, with free home sample collection available.
Is the test covered by insurance?
This test may not be covered by insurance. It is recommended to check with your insurance provider for coverage details before scheduling the test.
How long does it take to get results?
Results are typically delivered within 3 to 4 weeks after sample collection, via online portal, email, or WhatsApp.
What sample is required for the test?
The test requires a blood sample, which can be collected as venous blood in an EDTA tube, extracted DNA, or one drop of blood on an FTA card.
Can this test detect other genetic conditions?
While focused on the STAT1 gene, the NGS technology can screen for other genetic mutations, but specific panels may be needed for comprehensive evaluation.
Who should consider this test?
Individuals with recurrent infections, a family history of immunodeficiency, autoimmune disorders, or persistent respiratory symptoms should consider this test after consulting a healthcare provider.
What is the significance of NGS in this test?
NGS allows for rapid, comprehensive analysis of multiple genes, including STAT1, providing detailed insights into genetic mutations that may increase infection risk.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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