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TCN2 Gene Transcobalamin II deficiency NGS Genetic Test

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TCN2 Gene Transcobalamin II deficiency NGS Genetic Test

Short Name: TCN2 Gene NGS Test

TCN2 Gene Transcobalamin II deficiency NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To diagnose Transcobalamin II deficiency by detecting mutations in the TCN2 gene using NGS technology, aiding in early intervention and management.

Test Code
2261
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Provide clinical history and undergo genetic counselling to draw a family pedigree chart for Transcobalamin II deficiency.

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or one drop blood on FTA card.

Step 3

Report Delivery

Sample is sent to the laboratory for NGS analysis.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counselling and assessment of clinical history.
2
During the Test:Sample collection and processing in the laboratory.
3
After the Test:Report generation and delivery to the patient.

About This Test

Who Should Get This Test

To diagnose Transcobalamin II deficiency by detecting mutations in the TCN2 gene using NGS technology, aiding in early intervention and management.

How to Prepare

  • Ensure sample is collected in a sterile environment.
  • Use appropriate containers for blood or FTA card.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card

Understanding Your Results

Results indicate the presence or absence of mutations in the TCN2 gene associated with Transcobalamin II deficiency.
Positive result: Pathogenic mutations detected, indicating deficiency.
Negative result: No mutations detected, but clinical correlation is advised.
⚠️ When to Consult a Doctor:

If symptoms persist or results show mutations, consult a geneticist or healthcare provider for further evaluation and management.

Risks & Considerations

  • ●Pain at puncture site
  • ●Bruising
  • ●Infection risk (rare)

Frequently Asked Questions

What is TCN2 Gene Transcobalamin II Deficiency?
It is a genetic disorder where mutations in the TCN2 gene lead to impaired vitamin B12 transport, causing various health problems.
Why is this test important?
Early diagnosis through NGS testing helps in timely treatment, preventing complications like anemia and neurological issues.
What are the common symptoms?
Symptoms include fatigue, weakness, anemia, numbness in extremities, loss of appetite, weight loss, and depression.
How is the test performed?
It involves analyzing DNA from a blood sample or extracted DNA using Next Generation Sequencing to detect TCN2 gene mutations.
What is the cost of the test?
The test costs INR 20000, which includes sample collection and report generation.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across numerous cities in India.
How long does it take to get results?
Results are typically delivered within 3 to 4 weeks via online portal, email, or WhatsApp.
What do the results mean?
A positive result indicates pathogenic mutations in the TCN2 gene, suggesting deficiency; negative results may require clinical correlation.
Are there any risks associated with the test?
The test involves minimal risks like pain, bruising, or rare infection from blood draw.
Can children undergo this test?
Yes, the test can be performed at any age, as it is a simple and painless procedure.
Is genetic counselling required before testing?
Yes, genetic counselling is recommended to understand implications and draw a family pedigree chart for Transcobalamin II deficiency.
How to book the test?
You can book online through DNA Labs India's website or contact them via the provided phone number for home collection or walk-in options.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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