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DNA Labs India

TNFRSF11B Gene Paget disease, juvenile NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

TNFRSF11B Gene Paget disease, juvenile NGS Genetic Test

Also known as: Osteoprotegerin Gene Test, OPG Gene Test

TNFRSF11B Gene Paget disease, juvenile NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To identify mutations in the TNFRSF11B gene that are associated with juvenile Paget disease, aiding in diagnosis, family screening, and management planning.

Test Code
5100
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Genetic counseling session and review of patient's clinical history and family pedigree are required before sample collection.

Step 2

Laboratory Analysis

Your sample is analyzed using NGS Technology in our laboratory.

Step 3

Report Delivery

A certified pathologist reviews and signs your report. You receive it as a secure PDF via email and WhatsApp.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history review are mandatory before testing.
2
During the Test:Sample collection via blood draw or FTA card; minimal discomfort.
3
After the Test:Results are delivered online; follow-up with a healthcare provider for interpretation.

About This Test

Who Should Get This Test

To identify mutations in the TNFRSF11B gene that are associated with juvenile Paget disease, aiding in diagnosis, family screening, and management planning.

How to Prepare

  • For blood sample: standard venipuncture procedure
  • For FTA card: collect one drop of blood and air-dry
  • Ensure proper labeling and transport to lab

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Genetic testing for TNFRSF11B can help diagnose juvenile Paget disease early, guide treatment decisions, and inform family planning."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the TNFRSF11B gene. A positive result confirms a genetic predisposition to juvenile Paget disease, while a negative result suggests no detected mutations, though clinical correlation is advised.
📊

Positive for pathogenic variant

Confirms genetic basis for juvenile Paget disease; recommend clinical management and family screening.

📊

Negative for pathogenic variant

No mutations detected; consider other genetic or environmental factors if symptoms persist.

📊

Variant of uncertain significance

Further testing or family studies may be needed for clarification.

⚠️ When to Consult a Doctor:

Consult a doctor if you experience symptoms like bone pain, deformity, or fractures, or if you have a family history of Paget disease. After testing, discuss results with a genetic counselor or specialist for appropriate management.

Risks & Considerations

  • ●Minor bruising or pain at blood draw site
  • ●Rare risk of infection
  • ●Psychological impact of genetic results

Frequently Asked Questions

What is the TNFRSF11B gene?
The TNFRSF11B gene encodes osteoprotegerin, a protein that regulates bone remodeling by inhibiting osteoclast activity. Mutations can lead to juvenile Paget disease.
What is juvenile Paget disease?
Juvenile Paget disease is a rare genetic disorder causing abnormal bone remodeling, leading to pain, deformity, and fractures, often presenting in childhood or adolescence.
How is the NGS Genetic Test performed?
The test uses Next-Generation Sequencing to analyze the entire coding region of the TNFRSF11B gene from a blood or DNA sample, identifying genetic variants.
What sample is required for the test?
A blood sample, extracted DNA, or one drop of blood on an FTA card can be used.
How long does it take to get results?
Results are typically available in 3 to 4 weeks after sample receipt.
What is the cost of the test?
The test costs INR 20000, with free home sample collection available across India.
Is home collection available?
Yes, free home sample collection is offered for online bookings in numerous cities across India.
What do the results mean?
A positive result indicates a pathogenic variant in TNFRSF11B, confirming genetic predisposition. A negative result means no variants were detected, but clinical correlation is advised.
Can this test be used for prenatal diagnosis?
Prenatal testing may be possible in high-risk families, but genetic counseling is essential to discuss implications and options.
Are there any risks associated with the test?
Risks are minimal, such as minor bruising from blood draw. Psychological impacts of results should be considered.
How accurate is the NGS genetic test?
NGS is highly accurate for detecting genetic variants, but accuracy depends on sample quality and laboratory standards. DNA Labs India follows stringent protocols.
What should I do if the test is positive?
Consult a genetic counselor or specialist for management options, family screening, and personalized care plans.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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