TNFSF11 Gene Osteopetrosis, autosomal recessive type 2 NGS Genetic Test
Short Name: TNFSF11 Osteopetrosis Test
Also known as: RANK Ligand Deficiency, Autosomal Recessive Osteopetrosis Type 2
TNFSF11 Gene Osteopetrosis, autosomal recessive type 2 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the TNFSF11 Gene Osteopetrosis NGS Genetic Test is to diagnose autosomal recessive type 2 osteopetrosis by identifying mutations in the TNFSF11 gene. It helps confirm clinical diagnoses, identify carriers who may not show symptoms, and provide information on the risk of recurrence in future pregnancies, aiding in informed medical and family planning decisions.
- Test Code
- 2456
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- NGS Technology
Sample Collection
Clinical history of the patient and a genetic counseling session to draw a pedigree chart of family members affected with TNFSF11 gene osteopetrosis.
Method: Venipuncture or FTA Card
Laboratory Analysis
Your sample is analyzed using NGS Technology in our laboratory.
Report Delivery
A certified pathologist reviews and signs your report. You receive it as a secure PDF via email and WhatsApp.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the TNFSF11 Gene Osteopetrosis NGS Genetic Test is to diagnose autosomal recessive type 2 osteopetrosis by identifying mutations in the TNFSF11 gene. It helps confirm clinical diagnoses, identify carriers who may not show symptoms, and provide information on the risk of recurrence in future pregnancies, aiding in informed medical and family planning decisions.
How to Prepare
- Use sterile techniques for blood collection
- For FTA card, apply one drop of blood and air-dry
- Label samples correctly with patient details
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Genetic testing for TNFSF11 mutations is crucial for confirming diagnosis and guiding family planning in osteopetrosis cases."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
- Insufficient sample volume
- Contaminated or hemolyzed samples
Understanding Your Results
No pathogenic variants
Normal result; no mutations detected in the TNFSF11 gene
Pathogenic variant detected
Confirms diagnosis of autosomal recessive type 2 osteopetrosis; genetic counseling recommended
Variant of uncertain significance
Further testing or family studies may be needed for clarification
Consult a doctor if symptoms of osteopetrosis are present, such as frequent fractures, developmental delays, or vision/hearing issues, or for family planning if there is a family history of the disorder.
Limitations
- ⚠May not detect all types of mutations, such as large deletions or duplications
- ⚠Results require interpretation by a genetic counselor or specialist
Risks & Considerations
- ●Minimal risks from blood draw, such as bruising or infection
- ●Psychological impact of genetic results
Interfering Factors
- ●Sample contamination
- ●Degraded DNA quality
Frequently Asked Questions
What is the TNFSF11 Gene Osteopetrosis NGS Genetic Test?
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What is the cost of the test in India?
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What sample types are accepted?
Is fasting required before the test?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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