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TNNT2 Gene Cardiomyopathy, familial hypertrophic type 2 NGS Genetic Test

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TNNT2 Gene Cardiomyopathy, familial hypertrophic type 2 NGS Genetic Test

Short Name: TNNT2 Gene Cardiomyopathy NGS Test

Also known as: Familial Hypertrophic Cardiomyopathy Type 2, TNNT2-Related Cardiomyopathy

TNNT2 Gene Cardiomyopathy, familial hypertrophic type 2 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To detect mutations in the TNNT2 gene associated with familial hypertrophic cardiomyopathy for diagnosis, risk assessment, family screening, and guiding treatment decisions.

Test Code
2524
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Genetic counseling session recommended to discuss implications and draw a pedigree chart.

Method: Venipuncture or Blood drop on FTA Card

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or blood drop on FTA card by a trained phlebotomist.

Step 3

Report Delivery

Sample labeled and transported to the laboratory for NGS analysis.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling session and informed consent required.
2
During the Test:Blood sample collection and submission to laboratory.
3
After the Test:Report generation, counseling, and clinical follow-up.

About This Test

Who Should Get This Test

To detect mutations in the TNNT2 gene associated with familial hypertrophic cardiomyopathy for diagnosis, risk assessment, family screening, and guiding treatment decisions.

How to Prepare

  • Fast for 8-10 hours if specified by physician
  • Bring valid ID and doctor's prescription
  • Inform about any medications or supplements
  • Avoid strenuous activity before sample collection

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic testing for TNNT2 mutations can aid in timely management, risk stratification, and family screening for hypertrophic cardiomyopathy."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 ml blood
ContainerEDTA tube or FTA Card
Collection MethodVenipuncture or Blood drop on FTA Card

Sample Stability

Blood: 24 hours at room temperature
DNA: stable for up to 7 days at 4°C
Sample Rejection Criteria:
  • Hemolyzed or clotted sample
  • Insufficient sample volume
  • Improperly labeled or contaminated sample

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the TNNT2 gene, aiding in diagnosis and risk assessment.
📊

Positive for pathogenic variant

Confirms genetic predisposition to familial hypertrophic cardiomyopathy; clinical correlation and family screening recommended.

📊

Negative for pathogenic variant

No TNNT2 mutations detected, but clinical symptoms may require further evaluation.

📊

Variant of Uncertain Significance (VUS)

Genetic variant identified but clinical significance unknown; follow-up testing and counseling advised.

⚠️ When to Consult a Doctor:

If symptoms persist, family history is positive, or after receiving test results, consult a cardiologist or geneticist for management.

Limitations

  • ⚠May not detect all genetic variants or deep intronic mutations
  • ⚠Requires genetic counseling for accurate interpretation
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minimal risk from blood draw (bruising, infection)
  • ●Psychological impact of genetic results
  • ●Potential for uncertain findings requiring further testing

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Hemolyzed blood sample

Compare With Similar Tests

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ComparisonTNNT2 Gene Cardiomyopathy, familial hypertrophic type 2 NGS Genetic Test

Frequently Asked Questions

What is TNNT2 gene cardiomyopathy?
It is a genetic form of hypertrophic cardiomyopathy caused by mutations in the TNNT2 gene, leading to thickening of the heart muscle.
What are the common symptoms?
Symptoms include chest pain, shortness of breath, fatigue, fainting, heart palpitations, and swelling in legs or abdomen.
How is TNNT2 gene cardiomyopathy diagnosed?
Diagnosis involves clinical evaluation, imaging tests (ECG, echocardiogram, MRI), and genetic testing to confirm TNNT2 mutations.
What is the NGS genetic test?
Next-generation sequencing (NGS) is an advanced method that analyzes DNA to detect mutations in the TNNT2 gene accurately and quickly.
What is the cost of the test in India?
The NGS genetic test for TNNT2 gene cardiomyopathy costs INR 20,000 at DNA Labs India.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What does a positive result mean?
A positive result indicates a pathogenic variant in the TNNT2 gene, increasing the risk for cardiomyopathy; clinical management and family screening are recommended.
Can this test be done for children?
Yes, the test can be performed on individuals of all ages, including children, especially if there is a family history.
Is the test covered by insurance?
Coverage varies by insurance provider; it is advisable to check with your insurer for specific details.
How accurate is the NGS test?
NGS is highly accurate for detecting genetic variants, but results should be interpreted in conjunction with clinical findings.
What should I do if I have a family history of cardiomyopathy?
Consult a genetic counselor or cardiologist for risk assessment and consider genetic testing for early detection and management.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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