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TRPM4 Gene Progressive familial heart block NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

TRPM4 Gene Progressive familial heart block NGS Genetic Test

Short Name: TRPM4 Gene NGS Test

Also known as: TRPM4 Gene Mutation Test, Progressive Familial Heart Block Genetic Test

TRPM4 Gene Progressive familial heart block NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To diagnose progressive familial heart block by detecting mutations in the TRPM4 gene, aiding in clinical management, risk assessment for family members, and guiding treatment decisions.

Test Code
5279
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Clinical history and genetic counseling session required.

Method: Venipuncture

Step 2

Laboratory Analysis

Blood sample collected via venipuncture.

Step 3

Report Delivery

Sample sent to lab for NGS analysis.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history review.
2
During the Test:Blood sample collection and DNA extraction.
3
After the Test:NGS analysis and report generation.

About This Test

Who Should Get This Test

To diagnose progressive familial heart block by detecting mutations in the TRPM4 gene, aiding in clinical management, risk assessment for family members, and guiding treatment decisions.

How to Prepare

  • Ensure proper sample labeling
  • Use sterile collection tubes
  • Transport sample at appropriate temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for TRPM4 mutations is crucial for early diagnosis and management of progressive familial heart block, helping to prevent complications like heart failure and sudden cardiac arrest."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 mL blood or equivalent DNA
ContainerEDTA tube or FTA card
Collection MethodVenipuncture

Sample Stability

Blood sample stable for 48 hours at room temperature
DNA extract stable for longer periods
Sample Rejection Criteria:
  • Hemolyzed sample
  • Insufficient sample volume
  • Improperly labeled sample

Understanding Your Results

Results indicate the presence or absence of mutations in the TRPM4 gene associated with progressive familial heart block.
📊

Positive for pathogenic mutation

Confirms diagnosis, risk assessment for family members, and guides management such as pacemaker implantation.

📊

Negative

No mutation detected, but clinical correlation needed if symptoms persist; consider other genetic tests.

📊

Variant of uncertain significance

Further testing and genetic counseling recommended to clarify clinical relevance.

⚠️ When to Consult a Doctor:

If symptoms of heart block are present, such as fainting or fatigue, or if there is a family history of the condition.

Limitations

  • ⚠May not detect all genetic variants
  • ⚠Results require clinical correlation
  • ⚠Genetic counseling recommended for interpretation

Risks & Considerations

  • ●Minimal risk from blood draw (e.g., bruising)
  • ●Potential psychological impact from results; genetic counseling mitigates this

Interfering Factors

  • ●Degraded DNA sample
  • ●Contamination during sample collection

Compare With Similar Tests

TestTRPM4 Gene Progressive familial heart block NGS Genetic TestCardiac Genetic Panel Test
ComparisonTRPM4 Gene Progressive familial heart block NGS Genetic Test

Frequently Asked Questions

What is the TRPM4 Gene Progressive Familial Heart Block NGS Genetic Test?
It is a genetic test that uses Next-Generation Sequencing to detect mutations in the TRPM4 gene, which is linked to progressive familial heart block, an inherited heart conduction disorder.
Who should consider this test?
Individuals with a family history of progressive familial heart block, those experiencing symptoms like fainting or fatigue, or those with abnormal ECG findings suggestive of heart block.
What are the symptoms of progressive familial heart block?
Symptoms include fatigue, shortness of breath, dizziness, fainting, and in severe cases, heart failure or sudden cardiac arrest.
How is the test performed?
A blood sample or extracted DNA is collected, often via venipuncture, and analyzed using NGS technology to identify mutations in the TRPM4 gene.
What is the cost of the test?
The test costs INR 20,000, which includes home sample collection and genetic counseling services.
Is home sample collection available?
Yes, free home sample collection is available across many cities in India for online bookings.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What does a positive result mean?
A positive result confirms a pathogenic mutation in the TRPM4 gene, indicating a diagnosis of progressive familial heart block and guiding management and family screening.
What if the result is negative?
A negative result means no pathogenic mutation was detected, but clinical correlation is needed if symptoms persist; other genetic causes may be considered.
Is genetic counseling necessary?
Yes, genetic counseling is recommended before and after testing to understand implications, interpret results, and discuss family planning or management options.
Are there any risks associated with the test?
The test involves minimal risks from blood draw, such as bruising. Psychological impacts are possible, but counseling helps address concerns.
How can I book the test?
You can book the test online through DNA Labs India's website or contact their customer service for assistance with home sample collection.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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