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TTN Gene Cardiomyopathy, dilated type 1G NGS Genetic Test

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TTN Gene Cardiomyopathy, dilated type 1G NGS Genetic Test

Short Name: TTN Cardiomyopathy NGS Test

Also known as: Titin Gene Mutation Test, TTN Gene Sequencing Test, Dilated Cardiomyopathy Genetic Test

TTN Gene Cardiomyopathy, dilated type 1G NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to detect mutations in the TTN gene that cause dilated cardiomyopathy type 1G, enabling accurate diagnosis, genetic counseling, and informed treatment decisions for affected individuals and their families.

Test Code
5210
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation required. Provide clinical history and family pedigree chart as advised.

Method: Venipuncture or finger-prick

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in the arm or a finger-prick for FTA card.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bleeding. Resume normal activities.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Schedule a genetic counseling session to discuss family history and test implications.
2
During the Test:Sample collection takes about 10-15 minutes; no pain beyond a needle prick.
3
After the Test:Results will be delivered in 3-4 weeks. Follow up with your doctor for interpretation.

About This Test

Who Should Get This Test

The purpose of this test is to detect mutations in the TTN gene that cause dilated cardiomyopathy type 1G, enabling accurate diagnosis, genetic counseling, and informed treatment decisions for affected individuals and their families.

How to Prepare

  • Ensure proper identification and labeling of the sample
  • Use sterile equipment for blood collection
  • Store samples at appropriate temperature until transport

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for TTN mutations is essential for early diagnosis and personalized management of dilated cardiomyopathy, especially in families with a history of heart disease."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 mL of blood
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or finger-prick

Sample Stability

Blood samples: Stable for 48 hours at 2-8°C
FTA cards: Stable at room temperature for extended periods
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Incorrectly labeled or insufficient sample volume
  • Samples without proper consent or documentation

Understanding Your Results

Results indicate whether pathogenic mutations in the TTN gene are present. A positive result confirms genetic predisposition to dilated cardiomyopathy, while a negative result suggests no known mutations, but does not exclude other causes.
📊

Positive for TTN mutation

Confirms genetic basis for dilated cardiomyopathy. Recommend genetic counseling and cardiac monitoring.

📊

Negative for TTN mutation

No pathogenic variants detected. Clinical correlation and further testing may be needed if symptoms persist.

📊

Variant of uncertain significance (VUS)

Genetic change detected but clinical significance unknown. Follow-up with specialist recommended.

⚠️ When to Consult a Doctor:

Consult a cardiologist or genetic specialist immediately if you experience symptoms like severe shortness of breath, chest pain, or fainting, or if you have a family history of heart disease.

Limitations

  • ⚠May not detect all genetic variants or mutations in non-coding regions
  • ⚠Results require interpretation by a genetic specialist
  • ⚠Does not rule out other causes of cardiomyopathy

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Psychological impact from test results, requiring genetic counseling

Interfering Factors

  • ●Poor sample quality or insufficient DNA
  • ●Contamination during sample collection or processing
  • ●Recent blood transfusions may affect DNA analysis

Frequently Asked Questions

What is the TTN Gene Cardiomyopathy Test?
It is a genetic test that uses NGS technology to identify mutations in the TTN gene, which can cause dilated cardiomyopathy type 1G.
Who should consider this test?
Individuals with symptoms of dilated cardiomyopathy, a family history of the condition, or those seeking genetic confirmation for diagnosis.
How is the test performed?
A blood sample or DNA extract is analyzed using next-generation sequencing to detect TTN gene mutations.
What is the cost of the test?
The test costs INR 20,000 in India, with free home sample collection available in many cities.
Is fasting required before the test?
No, fasting is not required for this genetic test.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What do the results mean?
Results indicate if TTN mutations are present. A positive result suggests genetic risk for dilated cardiomyopathy, while negative means no known mutations.
Are there any risks associated with the test?
Risks are minimal, such as bruising from blood draw. Genetic counseling is recommended to address psychological impacts.
Can this test diagnose other types of cardiomyopathy?
No, it specifically targets TTN gene mutations linked to dilated cardiomyopathy type 1G. Other tests may be needed for different types.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across numerous cities in India.
What should I do after receiving the results?
Consult a cardiologist or genetic specialist to interpret results and discuss management options.
Is genetic testing necessary for all dilated cardiomyopathy cases?
Not always. It is recommended when there is a suspected genetic cause or family history, as advised by your doctor.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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