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ZNF778 Gene Autism, ZNF778 Related NGS Genetic Test

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ZNF778 Gene Autism, ZNF778 Related NGS Genetic Test

Short Name: ZNF778 Autism NGS

Also known as: ZNF778 Gene Sequencing, ZNF778 Related Autism NGS Panel, ZNF778 Gene Mutation Test

ZNF778 Gene Autism, ZNF778 Related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are issued within 3 to 4 weeks from receipt of sample at the laboratory.. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify pathogenic mutations in the ZNF778 gene that are associated with autism spectrum disorder. It supports clinical diagnosis, helps families understand the genetic basis of the condition, and facilitates informed genetic counseling.

Test Code
3932
ICD Code
F84.0
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Reports are issued within 3 to 4 weeks from receipt of sample at the laboratory.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation or fasting is required. It is recommended to have a genetic counselling session before the test. Please bring a valid ID and test requisition form.

Method: Venipuncture or Finger-prick

Step 2

Laboratory Analysis

A simple blood sample will be collected by a trained phlebotomist. If an FTA card is used, a small drop of blood will be placed on the card.

Step 3

Report Delivery

There are no activity restrictions. You can resume normal activities immediately after sample collection. The sample will be sent to the laboratory for analysis.

Timeline: Reports are issued within 3 to 4 weeks from receipt of sample at the laboratory.

Patient Instructions

1
Before the Test:A genetic counselling session is recommended to ensure informed consent. No fasting required. A pedigree chart will be prepared to assess family history.
2
During the Test:The sample is collected via a blood draw or FTA card. The process takes a few minutes and is generally painless.
3
After the Test:You will receive the clinical report along with raw data files (FASTQ, BAM, VCF) within 3-4 weeks. Your physician or genetic counselor will explain the results.

About This Test

Who Should Get This Test

The purpose of this test is to identify pathogenic mutations in the ZNF778 gene that are associated with autism spectrum disorder. It supports clinical diagnosis, helps families understand the genetic basis of the condition, and facilitates informed genetic counseling.

How to Prepare

  • No fasting required
  • Home sample collection available
  • Ensure correct patient identification
  • Complete the genetic counseling questionnaire

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for ZNF778 is recommended in individuals with autism spectrum disorder who have no identifiable cause after clinical evaluation. It helps in confirming diagnosis, guiding clinical management, and providing recurrence risk information for the family."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required for testing
ContainerEDTA Tube / DNA tube / FTA Card
Collection MethodVenipuncture or Finger-prick

Sample Stability

Whole blood (EDTA): 24 hours at room temperature
Extracted DNA: 7 days at 2-8°C
FTA card sample: 3 months at room temperature
Sample Rejection Criteria:
  • Hemolyzed blood sample
  • Clotted sample without proper mixing
  • Incorrectly labelled sample
  • Sample received in unapproved container

Understanding Your Results

The ZNF778 gene NGS test result is interpreted in the context of the patient's clinical presentation, family history, and ACMG guidelines. A positive test for a pathogenic variant confirms a genetic predisposition for ZNF778-related autism spectrum disorder.
Pathogenic or Likely Pathogenic variant: Indicates the presence of a ZNF778 mutation associated with ASD.
Variant of Uncertain Significance (VUS): Additional testing of family members may be required.
No pathogenic variant detected: Does not exclude autism, but reduces the likelihood of ZNF778-related diagnosis.
⚠️ When to Consult a Doctor:

If you or your child has symptoms of autism spectrum disorder, such as speech delays, social communication challenges, or repetitive behaviors, consult a developmental pediatrician, neurologist, or psychiatrist. A genetic counselor can also help in deciding the right genetic test.

Limitations

  • ⚠NGS may not detect large genomic rearrangements, repeat expansions, or deletions involving regulatory regions.
  • ⚠Some variants of uncertain significance (VUS) may be reported which require further analysis.
  • ⚠This test does not rule out other genetic or non-genetic causes of autism.

Risks & Considerations

  • ●Minimal pain or bruising at the site of blood draw
  • ●No significant medical risks associated with the test

Interfering Factors

  • ●N/A

Frequently Asked Questions

What is the ZNF778 gene?
ZNF778 is a gene that provides instructions for making a transcription factor involved in regulating gene expression. Mutations in this gene have been associated with autism spectrum disorder.
How is the ZNF778 gene autism NGS test performed?
The test uses next-generation sequencing (NGS) technology to analyze the coding and flanking regions of the ZNF778 gene. A blood, extracted DNA, or FTA card sample is collected and processed at the laboratory.
What is the cost of the ZNF778 gene autism NGS genetic test in India?
The test cost is INR 20,000 at DNA Labs India. At-home sample collection is free when booked online.
Is fasting required before the ZNF778 NGS genetic test?
No, fasting is not required for this genetic test. You can eat and drink normally before sample collection.
What sample types are accepted for this test?
The accepted samples are whole blood (EDTA tube), extracted DNA, or one drop of blood on an FTA card.
How long does it take to get the results?
Clinical reports are typically provided within 3 to 4 weeks after the sample is received at the laboratory.
Can this test diagnose autism?
This test does not diagnose autism by itself. It identifies variants in the ZNF778 gene that may be associated with autism spectrum disorder. A diagnosis is made by a physician using developmental assessments and genetic findings.
What kind of mutations does the NGS test detect?
NGS can detect single nucleotide variants, small insertions/deletions, and some copy number changes in the ZNF778 coding region.
Why is a genetic counselling session recommended before testing?
Genetic counselling helps in documenting family history, drawing a pedigree chart, and providing informed consent before testing. It also helps patients understand the implications of test results.
What will I receive with my report?
DNA Labs India provides a conclusive clinical report along with raw data files (FASTQ, BAM/VCF) for transparency and future reference.
Is the ZNF778 NGS test available in my city?
The test is available across major Indian cities including Mumbai, Delhi, Bangalore, Hyderabad, Chennai, Kolkata, Pune, and more. Home collection is offered in these locations.
Does insurance cover the cost of this genetic test?
Coverage depends on your individual insurance policy. It is recommended to check with your insurer or contact DNA Labs India for assistance.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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