5-Flurouracil (5-FU) Toxicity and Chemotherapeutic Response (DPYD Variants) Test
Short Name: 5-FU Toxicity and Response Test
Also known as: DPYD Gene Test, 5-FU Sensitivity Test, Dihydropyrimidine Dehydrogenase Variant Test
5-Flurouracil (5-FU) Toxicity and Chemotherapeutic Response (DPYD Variants) Test test available at DNA Labs India for ₹5,250. Uses Sanger Sequencing on Peripheral blood samples. Results in 3-4 days. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To identify DPYD gene variants that affect the metabolism of 5-fluorouracil, helping to predict toxicity risk and chemotherapeutic response for personalized cancer treatment.
- Test Code
- 2938
- Price
- ₹5,250
- Sample Type
- Peripheral blood
- Result Time
- 3-4 days
- Fasting Required
- No
- Method
- Sanger Sequencing
Sample Collection
No special preparation required. Ensure proper identification and inform the healthcare provider of any medications or recent transfusions.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn from a vein in your arm using a sterile needle and vacutainer.
Report Delivery
Apply pressure to the puncture site with a cotton ball to stop bleeding. Avoid strenuous activity for a few hours.
Timeline: 3-4 days
Patient Instructions
About This Test
Who Should Get This Test
To identify DPYD gene variants that affect the metabolism of 5-fluorouracil, helping to predict toxicity risk and chemotherapeutic response for personalized cancer treatment.
How to Prepare
- Ensure patient identification is accurate
- Use sterile equipment and follow aseptic techniques
- Label the sample correctly with patient details
- Transport the sample to the lab within the specified stability period
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing for DPYD variants is crucial before initiating 5-FU chemotherapy to prevent severe toxicity and optimize treatment outcomes, enabling personalized cancer care."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or lipemic sample
- Insufficient sample volume
- Improperly labeled or contaminated sample
- Sample received beyond stability period
Understanding Your Results
No variants detected
Normal DPYD function; standard 5-FU dosing may be appropriate, but clinical monitoring is still advised.
Heterozygous variant detected
Reduced DPD activity; increased risk of 5-FU toxicity. Consider dose reduction or alternative therapy.
Homozygous variant detected
Significantly reduced or absent DPD activity; high risk of severe toxicity. Avoid 5-FU or use with extreme caution under specialist supervision.
If you experience severe symptoms after chemotherapy, such as persistent diarrhea, fever, or mouth sores, or if you have questions about your test results and treatment options.
Limitations
- ⚠Only detects specific DPYD variants; does not cover all genetic factors influencing 5-FU metabolism
- ⚠Results should be interpreted in conjunction with clinical history and other diagnostic tests
- ⚠Does not predict all possible adverse effects of chemotherapy
Risks & Considerations
- ●Minor bruising or pain at the puncture site
- ●Rare risk of infection or fainting
- ●No significant long-term risks associated with genetic testing
Interfering Factors
- ●Recent blood transfusion
- ●Sample contamination or improper handling
- ●Use of certain medications that may affect DNA quality
Compare With Similar Tests
| Test | 5-Flurouracil (5-FU) Toxicity and Chemotherapeutic Response (DPYD Variants) | DPYD Full Gene Sequencing | UGT1A1 Genotyping | Thiopurine Methyltransferase (TPMT) Test |
|---|---|---|---|---|
| Comparison | 5-Flurouracil (5-FU) Toxicity and Chemotherapeutic Response (DPYD Variants) |
Frequently Asked Questions
What is the DPYD gene?
Why is DPYD variant testing important before chemotherapy?
What are the symptoms of 5-FU toxicity?
How is the test performed?
What does a positive result mean?
Can DPYD variants affect other drugs?
Is the test covered by insurance?
How long does it take to get results?
What should I do if I have a DPYD variant?
Is home sample collection available?
What is the cost of the test?
How accurate is the genetic test?
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Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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