BCR-ABL Gene Rearrangement PCR Qualitative Test
Short Name: BCR-ABL PCR Qualitative
Also known as: Philadelphia Chromosome Test, BCR-ABL Fusion Gene PCR
BCR-ABL Gene Rearrangement PCR Qualitative Test test available at DNA Labs India for ₹5,000. Uses Real Time PCR on Whole blood / Bone marrow samples. Results in Reports available within 1-2 days after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To qualitatively detect the BCR-ABL gene rearrangement for diagnosing and monitoring chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL).
- Test Code
- 191
- Price
- ₹5,000
- Sample Type
- Whole blood / Bone marrow
- Result Time
- Reports available within 1-2 days after sample receipt.
- Fasting Required
- No
- Method
- Real Time PCR
Sample Collection
No special preparation required. Ensure proper identification and sample labeling.
Method: Venipuncture or bone marrow aspiration
Laboratory Analysis
Collect 5 mL whole blood via venipuncture or bone marrow sample as per standard procedure. Use Lavender Top (EDTA) tube.
Report Delivery
Ship refrigerated immediately. Do not freeze. Ensure sample integrity during transport.
Timeline: Reports available within 1-2 days after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
To qualitatively detect the BCR-ABL gene rearrangement for diagnosing and monitoring chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL).
How to Prepare
- Collect 5 mL (3 mL min.) whole blood or bone marrow in a Lavender Top (EDTA) tube.
- Mix gently to prevent clotting.
- Ship refrigerated within 24 hours of collection.
- Do not freeze the sample.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This test is essential for confirming BCR-ABL gene rearrangement in suspected leukemia cases, guiding treatment decisions and monitoring response."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample received frozen
- Clotted or hemolyzed sample
- Incorrect container type
- Insufficient volume (<3 mL)
- Sample older than 4 days at refrigerator temperature
Understanding Your Results
Positive
BCR-ABL gene rearrangement detected, consistent with CML or ALL. Clinical evaluation and further testing recommended.
Negative
No BCR-ABL gene rearrangement detected. However, if clinical suspicion remains, repeat testing or quantitative PCR may be advised.
Consult an oncologist or hematologist if the test is positive, if symptoms persist despite a negative result, or for interpretation of results in the context of other clinical findings.
Limitations
- ⚠Qualitative test only—does not quantify BCR-ABL levels
- ⚠False negatives possible if tumor burden is very low
- ⚠False positives due to contamination or technical errors
- ⚠Cannot detect all BCR-ABL variants or other genetic abnormalities
Risks & Considerations
- ●Minimal risks from blood draw: bruising, soreness, or infection
- ●Bone marrow aspiration may involve pain, bleeding, or rarely, infection
Interfering Factors
- ●Sample contamination
- ●Hemolysis or clotted blood sample
- ●Improper sample storage (e.g., freezing when not required)
- ●Presence of inhibitors in the sample affecting PCR amplification
Compare With Similar Tests
| Test | BCR-ABL Gene Rearrangement PCR Qualitative Test | BCR-ABL PCR Quantitative Test | FISH for Philadelphia Chromosome |
|---|---|---|---|
| Comparison | BCR-ABL Gene Rearrangement PCR Qualitative Test |
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