Chromosome Analysis Philadelphia Test
Short Name: Philadelphia Chromosome Test
Also known as: Philadelphia Chromosome Analysis, Ph Chromosome Test, Karyotyping for Philadelphia Chromosome
Chromosome Analysis Philadelphia Test test available at DNA Labs India for ₹4,000. Uses Cell Culture, Microscopy, Karyotyping on Bone marrow aspirate (1.5 mL min.) samples. Results in 7 working days. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The primary purpose of the Chromosome Analysis Philadelphia Test is to identify the presence of the Philadelphia chromosome, which is crucial for diagnosing chronic myeloid leukemia (CML) and other related hematological disorders. It helps in confirming genetic abnormalities that may cause symptoms like developmental delays or infertility, enabling targeted treatment and genetic counseling.
- Test Code
- 310
- Price
- ₹4,000
- Sample Type
- Bone marrow aspirate (1.5 mL min.)
- Result Time
- 7 working days
- Fasting Required
- No
- Method
- Cell Culture, Microscopy, Karyotyping
Sample Collection
Duly filled Chromosome & FISH Analysis Requisition form (Form 17) is mandatory. Ensure sample collection is scheduled appropriately.
Method: Bone marrow aspiration
Laboratory Analysis
Bone marrow aspiration performed by a healthcare professional using a heparinized tube.
Report Delivery
Sample must be refrigerated immediately and shipped to the lab within 24 hours. Do not freeze.
Timeline: 7 working days
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the Chromosome Analysis Philadelphia Test is to identify the presence of the Philadelphia chromosome, which is crucial for diagnosing chronic myeloid leukemia (CML) and other related hematological disorders. It helps in confirming genetic abnormalities that may cause symptoms like developmental delays or infertility, enabling targeted treatment and genetic counseling.
How to Prepare
- Collect bone marrow sample in Sodium Heparin tube.
- Ship refrigerated immediately.
- Do not freeze the sample.
- Include completed requisition form (Form 17).
- Ensure sample reaches the lab within 24 hours.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This test is crucial for diagnosing chromosomal abnormalities, including Philadelphia chromosome in chronic myeloid leukemia, and should be considered for patients with symptoms like unexplained fatigue, weight loss, or recurrent infections."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample frozen or not refrigerated
- Insufficient sample volume (less than 1.5 mL)
- Missing or incomplete requisition form
- Sample received after 24 hours of collection
Understanding Your Results
Positive for Philadelphia chromosome
Presence of t(9;22)(q34;q11.2) translocation, indicative of CML or related disorders. Further clinical evaluation and treatment planning are recommended.
Normal karyotype
No chromosomal abnormalities detected, including absence of Philadelphia chromosome. Clinical correlation is advised if symptoms persist.
Other chromosomal abnormalities
Detection of non-Philadelphia abnormalities, which may indicate different genetic conditions. Consult a geneticist for detailed analysis.
Consult your doctor if you experience symptoms such as unexplained fatigue, weight loss, night sweats, recurrent infections, or if you have a family history of genetic disorders. Early diagnosis can improve management outcomes.
Limitations
- ⚠May not detect all chromosomal abnormalities
- ⚠Requires viable cells for accurate analysis
- ⚠Cannot identify gene-level mutations without additional tests like FISH
Risks & Considerations
- ●Minimal risks from bone marrow aspiration, such as bruising, infection, or discomfort at the collection site.
Interfering Factors
- ●Improper sample storage (e.g., freezing)
- ●Delayed sample processing beyond 24 hours
- ●Contaminated or insufficient sample volume
Compare With Similar Tests
| Test | Chromosome Analysis Philadelphia Test | FISH for BCR-ABL1 | Karyotyping | Bone Marrow Biopsy | Complete Blood Count (CBC) |
|---|---|---|---|---|---|
| Comparison | Chromosome Analysis Philadelphia Test | More specific for Philadelphia chromosome detection using fluorescent probes, often used as a confirmatory test. | Standard method for chromosome analysis, provides a comprehensive view of chromosomal structure and number. | Invasive procedure to examine bone marrow cells, often combined with chromosome analysis for hematological disorders. | Routine blood test that may show abnormalities suggestive of leukemia but does not detect specific chromosomal changes. |
Frequently Asked Questions
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