DPD Gene Mutations (5-FU Toxicity) Detection Test
Short Name: DPD Gene Mutation Test
Also known as: DPD Gene Mutation Analysis, 5-FU Toxicity Risk Assessment, Dihydropyrimidine Dehydrogenase Deficiency Test
DPD Gene Mutations (5-FU Toxicity) Detection Test test available at DNA Labs India for ₹9,828. Uses PCR on Whole blood samples. Results in 12-15 working days. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To detect mutations in the DPD gene that increase the risk of severe toxicity from 5-fluorouracil (5-FU) chemotherapy, enabling personalized treatment planning and prevention of adverse effects.
- Test Code
- 16
- Price
- ₹9,828
- Sample Type
- Whole blood
- Result Time
- 12-15 working days
- Fasting Required
- No
- Method
- PCR
Sample Collection
Ensure the Genomics Clinical Information Requisition Form (Form 20) is duly filled and signed by the referring physician.
Method: Venipuncture
Laboratory Analysis
A blood sample will be collected via venipuncture from a vein in the arm using standard phlebotomy procedures.
Report Delivery
The sample will be properly labeled, stored refrigerated, and shipped to the laboratory for analysis without freezing.
Timeline: 12-15 working days
Patient Instructions
About This Test
Who Should Get This Test
To detect mutations in the DPD gene that increase the risk of severe toxicity from 5-fluorouracil (5-FU) chemotherapy, enabling personalized treatment planning and prevention of adverse effects.
How to Prepare
- Collect 4 mL whole blood in a Lavender top (EDTA) tube
- Ship refrigerated; do not freeze the sample
- Include the duly filled Genomics Clinical Information Requisition Form (Form 20) with the sample
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"DPD gene testing is crucial before initiating 5-FU-based chemotherapy to prevent severe adverse reactions and personalize treatment plans for improved patient outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed sample
- Insufficient sample volume
- Missing or incomplete Genomics Clinical Information Requisition Form (Form 20)
- Improper sample storage
Understanding Your Results
Negative
No DPD gene mutations detected; standard 5-FU dosing may be considered with monitoring.
Positive
DPD gene mutation present; increased risk of 5-FU toxicity. Dose reduction, alternative therapy, or enhanced monitoring recommended.
Consult your doctor if you are scheduled for chemotherapy with 5-FU, have a family history of DPD deficiency, or have experienced severe side effects from previous chemotherapy treatments.
Limitations
- ⚠Does not detect all possible DPD gene mutations
- ⚠Requires clinical correlation for treatment decisions
- ⚠Positive results may need confirmation via sequencing
Risks & Considerations
- ●Minimal risks from blood draw: slight pain, bruising, or infection at the puncture site
Interfering Factors
- ●Hemolyzed blood sample
- ●Improper sample storage or handling
- ●Contamination during sample collection
Frequently Asked Questions
What is the DPD Gene Mutations Detection Test?
Why is this test important before chemotherapy?
What are the symptoms of 5-FU toxicity?
How is the test performed?
What does a positive result mean?
Can this test prevent chemotherapy side effects?
Is the test covered by insurance?
How long does it take to get results?
What sample is required for the test?
Are there any risks associated with the test?
How accurate is the test?
Where can I get this test done?
Related Tests
Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
Book Your Test
Enter your details and we'll connect you within 15 minutes.