AIP Gene Pituitary adenoma, growth hormone-secreting, due to AIP germline mutation NGS Genetic Test
Short Name: AIP Gene NGS Test
Also known as: AIP Gene Mutation Test, AIP Germline Mutation NGS, Pituitary Adenoma Genetic Test
AIP Gene Pituitary adenoma, growth hormone-secreting, due to AIP germline mutation NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood samples. Results in Results are typically available within 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The purpose of this test is to confirm the diagnosis of growth hormone-secreting pituitary adenoma caused by AIP germline mutations, assess the risk of developing such tumors in asymptomatic family members, and guide treatment and surveillance strategies.
- Test Code
- 6010
- CPT Code
- 81479
- ICD Code
- D35.2
- Price
- ₹20,000
- Sample Type
- Blood
- Result Time
- Results are typically available within 3 to 4 weeks after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation is required. However, a genetic counseling session is recommended before the test to discuss the implications of results.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn from a vein in your arm by a trained phlebotomist.
Report Delivery
You may resume normal activities immediately. The sample will be sent to the laboratory for analysis.
Timeline: Results are typically available within 3 to 4 weeks after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to confirm the diagnosis of growth hormone-secreting pituitary adenoma caused by AIP germline mutations, assess the risk of developing such tumors in asymptomatic family members, and guide treatment and surveillance strategies.
How to Prepare
- No fasting required.
- Inform the lab if you have had a blood transfusion or bone marrow transplant recently.
- Bring a valid ID and any relevant medical records.
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"Early detection of AIP germline mutations is crucial for managing growth hormone-secreting pituitary adenomas, enabling timely intervention and family screening."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed sample
- Clotted sample
- Incorrect labeling
- Sample received after prolonged transit time without proper temperature control
Understanding Your Results
Positive (pathogenic variant detected)
Confirms the diagnosis of AIP-related pituitary adenoma. Genetic counseling and family screening are recommended.
Action: Discuss with oncologist and genetic counselor for surveillance and treatment options.
Negative (no pathogenic variant detected)
No AIP germline mutation found. Other genetic or sporadic causes may be considered.
Action: Further evaluation may be needed based on clinical symptoms.
Variant of uncertain significance (VUS)
A genetic variant was found but its impact on health is not yet known.
Action: Additional testing or family studies may help clarify the significance.
Consult your doctor if you experience symptoms of acromegaly such as enlarged hands or feet, facial changes, excessive sweating, or persistent headaches. Also, if you have a family history of pituitary tumors, genetic testing is recommended.
Limitations
- ⚠This test detects germline mutations only, not somatic mutations in tumor tissue.
- ⚠Variants of uncertain significance may be reported; further analysis may be needed.
- ⚠Not all pituitary adenomas are caused by AIP mutations; negative result does not exclude other genetic causes.
- ⚠Regulatory regions and deep intronic variants may not be covered by standard NGS.
Risks & Considerations
- ●Minimal risk of bruising or bleeding at the puncture site
- ●Rare risk of infection
- ●Psychological impact of genetic test results
Interfering Factors
- ●Contamination of sample during collection
- ●DNA degradation due to improper storage
- ●Recent blood transfusion (within 2 weeks)
- ●Bone marrow transplantation
Compare With Similar Tests
| Test | AIP Gene Pituitary adenoma, growth hormone-secreting, due to AIP germline mutation NGS Genetic Test | MEN1 Gene Mutation Test | CDKN1B Gene Mutation Test | Pituitary Tumor Panel (NGS) |
|---|---|---|---|---|
| Comparison | AIP Gene Pituitary adenoma, growth hormone-secreting, due to AIP germline mutation NGS Genetic Test |
Frequently Asked Questions
What is the cost of the AIP gene pituitary adenoma NGS test?
What sample is required for this test?
Do I need to fast before the test?
How long does it take to get results?
Is home sample collection available?
What does a positive result mean?
Can this test be used for family screening?
Is genetic counseling included?
Are there any risks associated with the test?
Will insurance cover the cost?
What is the turnaround time for reports?
Can this test detect all pituitary adenoma causes?
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Reference Laboratory Services
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