AIP Gene Pituitary adenoma, prolactin-secreting, due to AIP germline mutation NGS Genetic Test
Short Name: AIP Gene NGS Test
Also known as: AIP Gene Mutation Test, Prolactinoma Genetic Test, AIP Germline NGS
AIP Gene Pituitary adenoma, prolactin-secreting, due to AIP germline mutation NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this NGS genetic test is to identify germline mutations in the AIP gene that are associated with an increased risk of developing prolactin-secreting pituitary adenomas. This test aids in confirming a clinical diagnosis, guiding treatment decisions, and enabling predictive testing for at-risk family members.
- Test Code
- 6011
- CPT Code
- 81479
- ICD Code
- D35.2
- Price
- ₹20,000
- Sample Type
- Blood
- Result Time
- 3 to 4 weeks
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No fasting required. However, a genetic counseling session is recommended before the test to discuss the implications of results. Please bring any relevant medical records or family history documents.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn from a vein in your arm. The procedure is quick and minimally invasive.
Report Delivery
You can resume normal activities immediately. The sample will be sent to the laboratory for analysis.
Timeline: 3 to 4 weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this NGS genetic test is to identify germline mutations in the AIP gene that are associated with an increased risk of developing prolactin-secreting pituitary adenomas. This test aids in confirming a clinical diagnosis, guiding treatment decisions, and enabling predictive testing for at-risk family members.
How to Prepare
- Ensure the sample is collected in an EDTA vacutainer.
- Label the sample correctly with patient details.
- Transport the sample to the laboratory at ambient temperature (15-25°C).
- Avoid hemolysis or clotting of the sample.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Early detection of AIP mutations is crucial for managing prolactin-secreting pituitary adenomas. This NGS test provides comprehensive genetic information to guide treatment and family screening."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted sample
- Incorrect anticoagulant (e.g., heparin)
- Sample received after 7 days without proper storage
- Mislabeled or unlabeled sample
Understanding Your Results
Positive (Pathogenic variant)
Confirms the diagnosis of AIP-related pituitary adenoma. Genetic counseling and family screening are recommended.
Action: Discuss with oncologist and genetic counselor for management and surveillance.
Negative (No pathogenic variant)
No AIP mutation detected. Other genetic or non-genetic causes may be considered.
Action: Further evaluation by endocrinologist or oncologist may be needed.
Variant of Uncertain Significance (VUS)
A genetic variant was found, but its clinical significance is unknown. Additional testing or family studies may help clarify.
Action: Consult with genetic counselor for further assessment.
If you experience symptoms such as persistent headaches, visual changes, unexplained infertility, or hormonal imbalances, consult an endocrinologist or oncologist. Also, if you have a family history of pituitary tumors, genetic testing may be recommended.
Limitations
- ⚠This test detects mutations only in the AIP gene; other genes associated with pituitary adenomas are not analyzed.
- ⚠Large deletions/duplications may not be detected by standard NGS; additional testing may be required.
- ⚠Variant of uncertain significance (VUS) may be reported; further family studies may be needed.
- ⚠This test does not assess somatic mutations in tumor tissue.
Risks & Considerations
- ●Minimal risk of bleeding or bruising at the puncture site
- ●Possible discomfort during blood draw
- ●Psychological impact of genetic results
Interfering Factors
- ●Contaminated or degraded DNA sample
- ●Recent blood transfusion (within 2 weeks)
- ●Bone marrow transplantation (may affect germline results)
- ●Incorrect sample labeling or handling
Compare With Similar Tests
| Test | AIP Gene Pituitary adenoma, prolactin-secreting, due to AIP germline mutation NGS Genetic Test | Sanger Sequencing | Multi-gene Panel | Whole Exome Sequencing |
|---|---|---|---|---|
| Comparison | AIP Gene Pituitary adenoma, prolactin-secreting, due to AIP germline mutation NGS Genetic Test |
Frequently Asked Questions
What is the cost of the AIP gene NGS genetic test?
What is the AIP gene?
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Who should consider this genetic test?
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Is fasting required before the test?
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