ALK Gene Neuroblastoma type 3, susceptibility to, familial NGS Genetic Test
Short Name: ALK Neuroblastoma NGS
Also known as: ALK gene mutation test, Familial neuroblastoma genetic test, ALK NGS panel
ALK Gene Neuroblastoma type 3, susceptibility to, familial NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are typically delivered within 3 to 4 weeks after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify germline mutations in the ALK gene that predispose to familial neuroblastoma type 3. It aids in confirming diagnosis in symptomatic individuals, presymptomatic testing in at-risk family members, and reproductive risk assessment.
- Test Code
- 5862
- CPT Code
- 81479
- ICD Code
- Z15.09
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are typically delivered within 3 to 4 weeks after sample receipt.
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
No fasting required. A genetic counseling session is recommended prior to testing to discuss implications.
Method: Venipuncture or FTA card spot
Laboratory Analysis
Blood sample is drawn by a trained phlebotomist. For FTA card, a drop of blood is placed on the card and allowed to dry.
Report Delivery
No special precautions. Resume normal activities.
Timeline: Reports are typically delivered within 3 to 4 weeks after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify germline mutations in the ALK gene that predispose to familial neuroblastoma type 3. It aids in confirming diagnosis in symptomatic individuals, presymptomatic testing in at-risk family members, and reproductive risk assessment.
How to Prepare
- Use EDTA tube for blood collection
- For FTA card, apply one drop of blood to each circle
- Label the sample with patient ID and date
- Transport at ambient temperature
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"Early identification of ALK mutations in familial neuroblastoma can guide surveillance and targeted therapy decisions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed blood sample
- Clotted blood sample
- Insufficient quantity
- Improperly labeled sample
- Sample received after prolonged transit without proper storage
Understanding Your Results
Positive (Pathogenic variant detected)
Confirms genetic susceptibility to familial neuroblastoma type 3. Recommend regular clinical surveillance and family testing.
Negative (No pathogenic variant detected)
No evidence of ALK-related familial neuroblastoma. However, other genetic causes may exist.
Variant of Uncertain Significance (VUS)
A genetic variant was found but its clinical significance is unknown. Further testing of family members may help clarify.
Consult a pediatric oncologist or clinical geneticist if you have a family history of neuroblastoma, or if your child shows symptoms such as abdominal swelling, bone pain, or unexplained fever.
Limitations
- ⚠This test detects mutations in the ALK gene only; other genes associated with neuroblastoma are not analyzed.
- ⚠Variant of uncertain significance (VUS) may be reported; further family studies may be needed.
- ⚠Somatic mutations (tumor-only) are not detected by this germline test.
- ⚠Regulatory regions and deep intronic variants may not be covered by NGS.
Risks & Considerations
- ●Minimal risk of bruising or infection at the blood draw site
- ●Psychological impact of genetic results
- ●Potential for incidental findings
Interfering Factors
- ●Contaminated or degraded DNA sample
- ●Insufficient sample quantity
- ●Recent blood transfusion (may dilute DNA)
- ●Bone marrow transplantation (may cause chimerism)
Compare With Similar Tests
| Test | ALK Gene Neuroblastoma type 3, susceptibility to, familial NGS Genetic Test | ALK Gene Single Site Analysis | Neuroblastoma Comprehensive Panel | Chromosomal Microarray (CMA) |
|---|---|---|---|---|
| Comparison | ALK Gene Neuroblastoma type 3, susceptibility to, familial NGS Genetic Test |
Frequently Asked Questions
What is the cost of the ALK Gene Neuroblastoma Type 3 NGS test?
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Is fasting required before the test?
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Can this test detect all neuroblastoma genes?
Is genetic counseling included?
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