ARL11 Gene Tumor predisposition syndrome, ARL11 related NGS Genetic Test
Short Name: ARL11 NGS Genetic Test
Also known as: ARL11 Gene Mutation Test, ARL11 Tumor Predisposition NGS Panel, ARL11 Cancer Risk Genetic Test
ARL11 Gene Tumor predisposition syndrome, ARL11 related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Results are typically available within 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to detect mutations in the ARL11 gene that are associated with tumor predisposition syndrome. It helps in confirming a clinical diagnosis, identifying at-risk individuals before symptoms appear, and guiding personalized cancer screening and prevention strategies. The test also aids in family planning and genetic counseling for affected families.
- Test Code
- 6025
- CPT Code
- 81479
- ICD Code
- Z15.09
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Results are typically available within 3 to 4 weeks after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation is required. However, a genetic counseling session is recommended prior to testing to discuss implications. Please inform your doctor about any medications or supplements you are taking.
Method: Venipuncture or Fingerstick
Laboratory Analysis
A blood sample will be drawn from a vein in your arm, or a fingerstick blood spot may be collected on an FTA card. The procedure is quick and minimally invasive.
Report Delivery
You may resume normal activities immediately. The sample will be sent to the laboratory for analysis. Results are typically available in 3 to 4 weeks.
Timeline: Results are typically available within 3 to 4 weeks after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to detect mutations in the ARL11 gene that are associated with tumor predisposition syndrome. It helps in confirming a clinical diagnosis, identifying at-risk individuals before symptoms appear, and guiding personalized cancer screening and prevention strategies. The test also aids in family planning and genetic counseling for affected families.
How to Prepare
- For blood sample: Use EDTA tube, fill to indicated mark, mix gently.
- For FTA card: Apply one drop of blood onto the designated circle, allow to air dry.
- Label the sample with patient name, date, and time of collection.
- Transport at ambient temperature (15-25°C) to the laboratory.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing for ARL11 mutations is crucial for early identification of tumor predisposition, enabling proactive surveillance and management. This NGS-based test offers comprehensive analysis for at-risk individuals."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume
- Improperly labeled sample
- Sample received after prolonged transit without proper storage
Understanding Your Results
Positive (Pathogenic variant detected)
Confirms diagnosis of ARL11 tumor predisposition syndrome. Increased risk of developing tumors. Recommend regular cancer screening and preventive measures.
Action: Consult oncologist for personalized surveillance plan. Inform family members for cascade testing.
Negative (No pathogenic variant detected)
No mutation found in ARL11 gene. However, risk due to other genes cannot be excluded.
Action: If strong family history persists, consider broader genetic testing or other diagnostic approaches.
Variant of Uncertain Significance (VUS)
A genetic change was found, but its impact on cancer risk is unknown.
Action: Further family studies and functional analysis may be recommended. Genetic counseling is advised.
Consult your doctor or a genetic counselor if you have a family history of ARL11-related tumors, if you have been diagnosed with multiple tumors at a young age, or if you are considering genetic testing for cancer risk assessment.
Limitations
- ⚠This test detects mutations in the ARL11 gene only; other genes are not analyzed.
- ⚠Variants of uncertain significance (VUS) may be reported; further family studies may be needed.
- ⚠Negative result does not rule out hereditary cancer risk due to other genes.
- ⚠Test is not intended for prenatal diagnosis.
Risks & Considerations
- ●Minimal risk of bruising or infection at the blood draw site
- ●Psychological impact of learning genetic risk
- ●Potential for uncertain results (VUS) requiring further investigation
Interfering Factors
- ●Contaminated or degraded DNA sample
- ●Insufficient sample quantity
- ●Presence of hematologic malignancies affecting DNA quality
- ●Recent blood transfusion (within 2 weeks) may dilute nucleated cells
Compare With Similar Tests
| Test | ARL11 Gene Tumor predisposition syndrome, ARL11 related NGS Genetic Test | BRCA1/BRCA2 Gene Mutation Test | TP53 Gene Mutation Test (Li-Fraumeni Syndrome) |
|---|---|---|---|
| Comparison | ARL11 Gene Tumor predisposition syndrome, ARL11 related NGS Genetic Test | BRCA1/2 are associated with breast and ovarian cancer risk, while ARL11 is linked to broader tumor predisposition. Both use NGS but target different genes. | TP53 mutations cause Li-Fraumeni syndrome with high cancer risk. ARL11 is a distinct gene with different tumor spectrum. |
Frequently Asked Questions
What is the ARL11 gene?
What does this test detect?
Who should consider this test?
What sample is required?
Is fasting required?
How long does it take to get results?
What is the cost of the test?
Is home sample collection available?
What does a positive result mean?
What does a negative result mean?
What is a variant of uncertain significance (VUS)?
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