Breast Cancer BRCA1 BRCA2 Gene Test
Short Name: BRCA Panel NGS
Also known as: BRCA1/BRCA2 Mutation Analysis, Hereditary Cancer Panel, BRCA Gene Test
Breast Cancer BRCA1 BRCA2 Gene Test test available at DNA Labs India for ₹14,000. Uses Next-Generation Sequencing (NGS) on Blood or Buccal Swab samples. Results in Report is typically available within 14-18 working days from the day the sample reaches the lab. You will receive a secure PDF via email and WhatsApp, followed by a genetic counseling call within 48 hours of report release.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The primary purpose of this test is to assess an individual's inherited risk of developing breast and ovarian cancer due to mutations in BRCA1, BRCA2, and other associated genes. It is prescribed for individuals with a personal or family history suggestive of hereditary cancer, such as early-onset breast cancer, multiple affected relatives, male breast cancer, or known BRCA mutations in the family. The results guide medical management, including screening recommendations, preventive options, and family counseling.
- Test Code
- 5991
- CPT Code
- 81162
- ICD Code
- Z15.01
- Price
- ₹14,000
- Sample Type
- Blood or Buccal Swab
- Result Time
- Report is typically available within 14-18 working days from the day the sample reaches the lab. You will receive a secure PDF via email and WhatsApp, followed by a genetic counseling call within 48 hours of report release.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No fasting required. Avoid biotin supplements for 3 days prior. Inform the lab if you are on blood thinners. If you have recently undergone chemotherapy or radiation, wait at least 3 weeks before sample collection.
Method: Venipuncture or Buccal Swab
Laboratory Analysis
A trained phlebotomist will collect a blood sample (2 mL) or a buccal swab (painless, no needles). The procedure takes about 5 minutes.
Report Delivery
You can resume normal activities immediately. No special precautions are needed.
Timeline: Report is typically available within 14-18 working days from the day the sample reaches the lab. You will receive a secure PDF via email and WhatsApp, followed by a genetic counseling call within 48 hours of report release.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of this test is to assess an individual's inherited risk of developing breast and ovarian cancer due to mutations in BRCA1, BRCA2, and other associated genes. It is prescribed for individuals with a personal or family history suggestive of hereditary cancer, such as early-onset breast cancer, multiple affected relatives, male breast cancer, or known BRCA mutations in the family. The results guide medical management, including screening recommendations, preventive options, and family counseling.
How to Prepare
- For blood sample: Use EDTA tube; ensure proper mixing to prevent clotting.
- For buccal swab: Do not eat, drink, or smoke for 30 minutes before collection.
- Label the sample with patient ID and collection date/time.
- Store sample at room temperature if shipped within 24 hours; otherwise refrigerate.
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"Genetic testing for BRCA mutations is crucial for personalized cancer risk assessment and management. Early identification allows for enhanced surveillance and preventive strategies."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume
- Sample collected during active chemotherapy/radiation without appropriate waiting period
- Improper labeling or missing requisition form
Understanding Your Results
Positive (Pathogenic Variant)
Inherited mutation detected; significantly increased risk of breast, ovarian, and other cancers. Recommend enhanced surveillance, risk-reducing options, and cascade testing for family members.
Negative (No Pathogenic Variant)
No known pathogenic variant found in the tested genes. However, risk may still be elevated due to other genetic or environmental factors; continue standard screening.
Variant of Uncertain Significance (VUS)
A genetic variant was found, but its impact on cancer risk is not yet known. Further family studies or reclassification may be needed; consult a genetic counselor.
Consult your doctor or genetic counselor if you have a personal or family history suggestive of hereditary cancer, or if you have received a positive or VUS result from this test. They can guide you on appropriate surveillance and preventive strategies.
Limitations
- ⚠This test detects inherited mutations but does not rule out sporadic (non-hereditary) breast cancer.
- ⚠Variants of uncertain significance (VUS) may be reported; their clinical significance is not always clear.
- ⚠The test does not analyze large genomic rearrangements unless specifically included; confirm with the lab.
- ⚠Results should be interpreted in the context of full clinical history and family pedigree by a qualified geneticist or oncologist.
Risks & Considerations
- ●Minimal risk of bruising or infection at the blood draw site
- ●Psychological impact of learning genetic risk
- ●Potential for VUS results causing uncertainty
Interfering Factors
- ●Biotin supplements (vitamin B7) may interfere with NGS chemistry; avoid for 3 days before sample collection.
- ●Recent chemotherapy or radiation may affect white blood cell counts and DNA yield; wait at least 3 weeks after treatment.
- ●Blood thinners may increase bleeding risk during blood draw; inform the collection team.
Compare With Similar Tests
| Test | Breast Cancer BRCA1 BRCA2 Gene Test | Single-Site BRCA Mutation Test | BRCA1/BRCA2 Full Sequencing | Multi-Gene Hereditary Cancer Panel |
|---|---|---|---|---|
| Comparison | Breast Cancer BRCA1 BRCA2 Gene Test |
Frequently Asked Questions
Is fasting required for BRCA genetic test in India?
Do you provide help in understanding my genetic test results?
How soon will I receive my ISO-certified digital report?
Is there an extra charge for home collection in my city?
How can I book BRCA panel NGS test via WhatsApp or Phone?
What is the difference between BRCA1 and BRCA2?
Can this test be done during pregnancy?
Will my insurance cover the cost of this test?
What is a variant of uncertain significance (VUS)?
How accurate is the NGS method used in this test?
Can I take the test if I have already been diagnosed with cancer?
What should I do if my result is positive?
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