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CACNA1C Gene Brugada syndrome type 3 NGS Genetic Test

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CACNA1C Gene Brugada syndrome type 3 NGS Genetic Test

Short Name: CACNA1C Brugada Type 3 Test

Also known as: CACNA1C Gene Test, Brugada Syndrome Type 3 Genetic Test, CACNA1C NGS Test

CACNA1C Gene Brugada syndrome type 3 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

To confirm a diagnosis of Brugada Syndrome Type 3 by identifying pathogenic mutations in the CACNA1C gene, and to screen family members for genetic risk to enable early intervention and management.

Test Code
5195
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation required. Provide detailed clinical history and family pedigree during genetic counseling.

Method: Venipuncture or finger-prick

Step 2

Laboratory Analysis

Blood sample will be collected by a trained phlebotomist using standard venipuncture or finger-prick method.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Resume normal activities immediately.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling session to discuss test implications, benefits, risks, and to draw a detailed family pedigree chart.
2
During the Test:Sample collection procedure as per standard protocol, typically involving a blood draw.
3
After the Test:Wait for the report (3-4 weeks) and follow up with your healthcare provider or geneticist for result interpretation and next steps.

About This Test

Who Should Get This Test

To confirm a diagnosis of Brugada Syndrome Type 3 by identifying pathogenic mutations in the CACNA1C gene, and to screen family members for genetic risk to enable early intervention and management.

How to Prepare

  • No fasting required for this test.
  • Bring a valid ID and prescription or referral.
  • Inform the collection center about any medications or recent blood transfusions.
  • Ensure sample is collected in the appropriate container (EDTA tube or FTA card).

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"Genetic testing for CACNA1C mutations is essential for diagnosing Brugada syndrome and guiding family screening to prevent sudden cardiac events."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 ml of blood
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or finger-prick

Sample Stability

Room temperature24 hours
Refrigerated (2-8°C)72 hours
Sample Rejection Criteria:
  • Hemolyzed sample
  • Insufficient sample volume
  • Contaminated sample
  • Incorrect sample container or labeling

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the CACNA1C gene, which are associated with Brugada syndrome type 3.
📊

Positive for pathogenic variant

Confirms diagnosis of Brugada syndrome type 3. Genetic counseling and cardiac evaluation are recommended for the patient and at-risk family members.

📊

Negative for pathogenic variant

No mutation detected in the CACNA1C gene. Clinical correlation is advised, as other genetic or non-genetic causes may be considered.

📊

Variant of uncertain significance (VUS)

A genetic variant was found, but its clinical significance is unclear. Further testing, family studies, and consultation with a geneticist are recommended.

⚠️ When to Consult a Doctor:

If you experience symptoms like fainting, palpitations, chest pain, or have a family history of sudden cardiac death or Brugada syndrome, consult a cardiologist or geneticist immediately for evaluation and possible testing.

Limitations

  • ⚠May not detect all genetic variants or mutations
  • ⚠Requires genetic counseling for accurate interpretation
  • ⚠Results should be correlated with clinical findings and family history
  • ⚠Does not rule out other genetic or non-genetic causes of Brugada syndrome

Risks & Considerations

  • ●Minimal risk from blood draw: bruising, soreness, or infection at puncture site
  • ●Psychological impact of genetic results, such as anxiety or stress
  • ●Potential for uncertain results requiring further investigation

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Hemolyzed blood sample
  • ●Recent blood transfusion

Frequently Asked Questions

What is the CACNA1C Gene Brugada Syndrome Type 3 NGS Genetic Test?
It is a genetic test that uses next-generation sequencing (NGS) to detect mutations in the CACNA1C gene, which are associated with Brugada syndrome type 3, a rare heart rhythm disorder.
How much does the test cost in India?
The cost of the CACNA1C Gene Brugada Syndrome Type 3 NGS Genetic Test at DNA Labs India is INR 20,000, with free home sample collection available across India.
What sample is required for the test?
The test requires a blood sample, extracted DNA, or one drop of blood on an FTA card. Typically, 3-5 ml of blood is collected via venipuncture.
How long does it take to get the results?
Results are typically available within 3 to 4 weeks after sample collection, and can be accessed online, via email, or WhatsApp.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test in numerous cities across India, including Mumbai, Delhi, Bangalore, and more.
What are the symptoms of Brugada syndrome?
Symptoms may include fainting or near-fainting episodes, palpitations, shortness of breath, chest pain, and abnormal heart rhythms. Some individuals may have no symptoms.
Who should consider this genetic test?
Individuals with a family history of Brugada syndrome or sudden cardiac death, those experiencing symptoms like fainting or palpitations, or those with abnormal ECG findings should consider this test.
How is the test performed?
The test involves collecting a blood sample, extracting DNA, and using next-generation sequencing to analyze the CACNA1C gene for mutations. It is performed in a certified laboratory.
What does a positive result mean?
A positive result confirms a diagnosis of Brugada syndrome type 3 due to a pathogenic mutation in the CACNA1C gene. Genetic counseling and cardiac evaluation are recommended.
What does a negative result mean?
A negative result means no pathogenic mutations were detected in the CACNA1C gene. However, clinical correlation is advised, as other causes may exist.
Are there any risks associated with the test?
The test has minimal risks, such as bruising from blood draw. There may be psychological impacts from results, so genetic counseling is provided.
How can I book the test?
You can book the test online through DNA Labs India's website, via phone, or WhatsApp. Free home sample collection is available for online bookings.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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