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CBFB-MYH11[Inv(16)] Qualitative Test

DNA Labs India | ISO 9001:2015 Certified

CBFB-MYH11[Inv(16)] Qualitative Test

Also known as: CBFB-MYH11 Fusion Gene Test, Inv(16) Qualitative Test

CBFB-MYH11[Inv(16)] Qualitative Test test available at DNA Labs India for ₹4,500. Uses Real Time PCR on Bone marrow / Peripheral blood samples. Results in 3-4 days. Free home collection in 300+ cities across India.

Qualitative Molecular Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The primary purpose of the CBFB-MYH11[Inv(16)] Qualitative Test is to confirm the diagnosis of AML with inv(16) by detecting the CBFB-MYH11 fusion gene. It is also used to monitor the effectiveness of treatment and detect minimal residual disease.

Test Code
2959
Price
₹4,500
Sample Type
Bone marrow / Peripheral blood
Result Time
3-4 days
Fasting Required
No
Method
Real Time PCR
Step 1

Sample Collection

No specific preparation required. Inform the doctor about any medications or recent procedures.

Method: Bone Marrow Aspiration or Venipuncture

Step 2

Laboratory Analysis

For bone marrow aspiration, local anesthesia is used. For blood draw, standard venipuncture procedure.

Step 3

Report Delivery

Apply pressure to the collection site to prevent bleeding. Monitor for any signs of infection.

Timeline: 3-4 days

Patient Instructions

1
Before the Test:No special preparation needed. Discuss medical history with your doctor.
2
During the Test:The test involves sample collection from bone marrow or blood. The procedure is quick and performed by a trained professional.
3
After the Test:Resume normal activities. Follow up with your doctor for results and interpretation.

About This Test

Who Should Get This Test

The primary purpose of the CBFB-MYH11[Inv(16)] Qualitative Test is to confirm the diagnosis of AML with inv(16) by detecting the CBFB-MYH11 fusion gene. It is also used to monitor the effectiveness of treatment and detect minimal residual disease.

How to Prepare

  • Transport the sample immediately to the laboratory.
  • Use EDTA vacutainer for blood samples.
  • Ensure proper labeling and documentation.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBone marrow / Peripheral blood
Sample Volume2 ml
ContainerEDTA Vacutainer
Collection MethodBone Marrow Aspiration or Venipuncture

Sample Stability

Bone marrow: Stable for 24 hours at room temperature.
Peripheral blood: Stable for 48 hours at 2-8°C.
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Insufficient sample volume
  • Improperly labeled samples

Understanding Your Results

Results of the CBFB-MYH11[Inv(16)] Qualitative Test indicate the presence or absence of the CBFB-MYH11 fusion gene.
📊

Positive

Detection of CBFB-MYH11 fusion gene confirms AML with inv(16). Consult an oncologist for treatment planning.

📊

Negative

No CBFB-MYH11 fusion gene detected. This does not rule out other types of leukemia; further testing may be needed.

⚠️ When to Consult a Doctor:

If you experience symptoms of leukemia such as persistent fever, fatigue, or easy bruising, or if you have been diagnosed with AML and need monitoring, consult your doctor for this test.

Limitations

  • ⚠This is a qualitative test; for quantitative monitoring, other tests may be needed.
  • ⚠False negatives or positives can occur due to technical issues.
  • ⚠Does not detect other genetic abnormalities in AML.

Risks & Considerations

  • ●For bone marrow biopsy: risk of infection, bleeding, or pain at the site.
  • ●For blood draw: minimal risk of bruising or dizziness.

Interfering Factors

  • ●Sample contamination
  • ●Improper sample storage or transport
  • ●Recent blood transfusions may affect results

Frequently Asked Questions

What is the CBFB-MYH11[Inv(16)] Qualitative Test?
It is a molecular test that detects the CBFB-MYH11 fusion gene, which is associated with a subtype of acute myeloid leukemia (AML) called AML with inv(16).
Why is this test performed?
To diagnose AML with inv(16), confirm the presence of the genetic abnormality, and monitor treatment response.
What sample is required for this test?
Bone marrow or peripheral blood samples are used, collected in an EDTA vacutainer.
Is fasting required before the test?
No, fasting is not required for this test.
How long does it take to get results?
Results are typically available within 3-4 days after sample collection.
What does a positive result mean?
A positive result indicates the presence of the CBFB-MYH11 fusion gene, confirming AML with inv(16). Consult your doctor for further management.
What does a negative result mean?
A negative result means the fusion gene was not detected. This does not rule out other forms of leukemia, and additional tests may be needed.
Is this test covered by insurance?
Coverage varies by insurance plan. It is advisable to check with your insurance provider for details.
Are there any risks associated with the test?
For bone marrow collection, there are minor risks like infection or bleeding. Blood draw has minimal risks such as bruising.
Can this test be done at home?
Yes, DNA Labs India offers free home sample collection for this test in many cities across India.
What is the cost of the test?
The cost is INR 4500, which includes the test, counseling, and support.
Who should consider this test?
Individuals with symptoms of AML, those diagnosed with AML for subtyping, or patients undergoing treatment for AML with inv(16) for monitoring.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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