Skip to main content
DNA Labs India

CBLIF Gene Intrinsic factor deficiency NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

CBLIF Gene Intrinsic factor deficiency NGS Genetic Test

Short Name: CBLIF Gene NGS Test

Also known as: GIF Gene Test, Intrinsic Factor Deficiency Genetic Test, Pernicious Anemia Genetic Test

CBLIF Gene Intrinsic factor deficiency NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify genetic mutations in the CBLIF gene that lead to intrinsic factor deficiency, enabling accurate diagnosis of the underlying cause of vitamin B12 malabsorption and guiding appropriate treatment strategies.

Test Code
5594
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation required. Inform the doctor about any medications or supplements.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in your arm. For FTA card, a drop of blood is collected.

Step 3

Report Delivery

Apply pressure to the puncture site to stop bleeding. Resume normal activities.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:No fasting required. Provide clinical history and family pedigree if possible.
2
During the Test:Sample collection and analysis in the lab.
3
After the Test:Receive report and consult with genetic counselor.

About This Test

Who Should Get This Test

The purpose of this test is to identify genetic mutations in the CBLIF gene that lead to intrinsic factor deficiency, enabling accurate diagnosis of the underlying cause of vitamin B12 malabsorption and guiding appropriate treatment strategies.

How to Prepare

  • Ensure proper identification
  • Use sterile equipment
  • Label samples correctly

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This NGS test identifies mutations in the CBLIF gene, crucial for diagnosing intrinsic factor deficiency and guiding treatment for vitamin B12 malabsorption."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 mL of blood
ContainerEDTA tube or FTA card
Collection MethodVenipuncture

Sample Stability

Blood: 24 hours at room temperature
Extracted DNA: stable for longer periods
Sample Rejection Criteria:
  • Hemolyzed sample
  • Insufficient volume
  • Improper labeling

Understanding Your Results

Results indicate the presence or absence of mutations in the CBLIF gene. Positive results suggest a genetic cause for intrinsic factor deficiency.
📊

No mutations detected

Low likelihood of genetic intrinsic factor deficiency

📊

Mutations detected

Genetic cause identified; consult geneticist for management

⚠️ When to Consult a Doctor:

If you experience symptoms of vitamin B12 deficiency or have a family history of pernicious anemia, consult a doctor for this test.

Limitations

  • ⚠May not detect all possible mutations
  • ⚠Results require clinical correlation
  • ⚠Genetic counseling recommended for interpretation

Risks & Considerations

  • ●Minimal risk from blood draw: bruising, infection

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Incorrect sample handling

Compare With Similar Tests

TestCBLIF Gene Intrinsic factor deficiency NGS Genetic TestVitamin B12 Level TestIntrinsic Factor Antibody Test
ComparisonCBLIF Gene Intrinsic factor deficiency NGS Genetic Test

Frequently Asked Questions

What is the CBLIF Gene Intrinsic Factor Deficiency NGS Genetic Test?
This test uses next-generation sequencing to analyze the CBLIF gene for mutations that cause intrinsic factor deficiency, leading to vitamin B12 malabsorption.
What does this test detect?
It detects genetic mutations in the CBLIF gene that result in inadequate production of intrinsic factor, a protein necessary for vitamin B12 absorption.
Who should consider taking this test?
Individuals with symptoms of vitamin B12 deficiency (e.g., fatigue, weakness, numbness) or diagnosed with pernicious anemia should consider this test.
How is the test performed?
A blood sample or extracted DNA is collected and analyzed using NGS technology to identify mutations in the CBLIF gene.
What is the cost of the test?
The test costs INR 20000 at DNA Labs India, including home sample collection and genetic counseling.
Is home sample collection available?
Yes, free home sample collection is available across India for online bookings.
How long does it take to receive the results?
Results are typically available within 3 to 4 weeks after sample collection.
What do the results mean?
Results indicate whether mutations are present. Positive results suggest a genetic cause for intrinsic factor deficiency, requiring further medical consultation.
Is genetic counseling included with the test?
Yes, a genetic counseling session is included to help interpret results and draw a family pedigree chart.
Can this test diagnose pernicious anemia?
It can identify genetic mutations associated with intrinsic factor deficiency, which is a cause of pernicious anemia, but clinical correlation is needed.
What are the symptoms of intrinsic factor deficiency?
Symptoms include fatigue, weakness, numbness or tingling, difficulty walking, loss of appetite, weight loss, depression, and memory loss.
How accurate is the NGS genetic test?
NGS technology provides high accuracy in detecting genetic mutations, but results should be interpreted by a geneticist in the context of clinical findings.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

Related Tests

Factor V Leiden Mutation Analysis Test

₹7,500

FIP1L1-PGDFRA Gene Rearrangement Detection Test

₹10,500

G-6-PD Quantitative Test

₹971

MPL (Myeloproliferative Leukemia) Gene Mutation Test

₹6,500

Thalassemia Alpha Mutation Analysis Test

₹5,500

Thalassemia Profile Test

₹1,814
For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

Book Your Test

Enter your details and we'll connect you within 15 minutes.

🧬

Quick Connect

Enter your mobile number and we’ll connect you with the team.

+91

✅ Connecting you now...

🔒 Your number is used to respond to this request.