CDK4 Gene Melanoma, cutaneous malignant, familial, CDK4 related NGS Genetic Test
Short Name: CDK4 Melanoma NGS Test
Also known as: CDK4 gene test for melanoma, Familial melanoma genetic test, CDK4 mutation analysis, Melanoma susceptibility gene test
CDK4 Gene Melanoma, cutaneous malignant, familial, CDK4 related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To identify mutations in the CDK4 gene associated with familial melanoma, enabling early risk assessment, personalized surveillance, and preventive interventions for individuals at high risk.
- Test Code
- 2891
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- NGS Technology
Sample Collection
No special preparation required. Inform the lab about any medications or recent medical procedures.
Method: Venipuncture
Laboratory Analysis
Standard blood draw procedure using venipuncture. For FTA card, a single drop of blood is applied.
Report Delivery
Apply pressure to the puncture site to prevent bleeding. Store samples as per instructions.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
To identify mutations in the CDK4 gene associated with familial melanoma, enabling early risk assessment, personalized surveillance, and preventive interventions for individuals at high risk.
How to Prepare
- Ensure proper identification of the patient
- Use sterile equipment for blood collection
- Label samples correctly with patient details
- Transport samples at ambient room temperature
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing for CDK4 mutations is crucial for early detection and management of familial melanoma, enabling personalized surveillance and preventive strategies."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed samples
- Insufficient sample volume
- Improperly labeled samples
- Contaminated samples
Understanding Your Results
Positive
Pathogenic variant detected in CDK4 gene. Increased risk for familial melanoma. Recommend genetic counseling and enhanced surveillance.
Negative
No pathogenic variants detected. Risk may be similar to general population, but clinical correlation is advised.
Variant of Uncertain Significance (VUS)
A genetic variant was found, but its clinical significance is unknown. Further testing and family studies may be needed.
Consult a doctor or genetic counselor if results are positive or if there is a family history of melanoma, to discuss risk management and surveillance plans.
Limitations
- ⚠May not detect all types of mutations (e.g., large deletions)
- ⚠Variants of uncertain significance (VUS) may be identified
- ⚠Requires clinical correlation and genetic counseling
- ⚠Test does not replace regular dermatological examinations
Risks & Considerations
- ●Minimal risks from blood draw, such as bruising or infection
- ●Psychological impact of genetic results
- ●Potential for variants of uncertain significance
Interfering Factors
- ●Sample contamination
- ●DNA degradation
- ●Recent blood transfusion
- ●Improper sample storage
Compare With Similar Tests
| Test | CDK4 Gene Melanoma, cutaneous malignant, familial, CDK4 related NGS Genetic Test | CDKN2A Gene Melanoma Test | BRAF Gene Mutation Test |
|---|---|---|---|
| Comparison | CDK4 Gene Melanoma, cutaneous malignant, familial, CDK4 related NGS Genetic Test | CDKN2A is another gene associated with familial melanoma; CDK4 test specifically targets CDK4 mutations. | BRAF mutations are common in melanoma but not specifically for familial risk; CDK4 test focuses on hereditary susceptibility. |
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