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Chronic Lymphocytic Leukemia (CLL) Prognostic Panel Test

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Chronic Lymphocytic Leukemia (CLL) Prognostic Panel Test

Short Name: CLL Prognostic Panel Test

Also known as: CLL Prognostic Panel, Chronic Lymphocytic Leukemia Prognostic Panel, CLL Prognostic Panel Test

Chronic Lymphocytic Leukemia (CLL) Prognostic Panel Test test available at DNA Labs India for ₹23,000. Uses PCR Sequencing, FISH, Flow cytometry on Whole blood or bone marrow samples. Results in Reports are usually available within 5-7 working days after sample acceptance.. Free home collection in 300+ cities across India.

Hematologist, OncologistAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The panel is used to identify genetic and immunophenotypic prognostic markers in CLL, including ZAP-70, CD38, CD49d, IGVH mutation status, del11q23 (ATM), del17p13.1 (TP53), del13q14.3, del13q34 and trisomy 12. These markers help estimate disease progression risk and guide treatment decisions.

Test Code
3462
Price
₹23,000
Sample Type
Whole blood or bone marrow
Result Time
Reports are usually available within 5-7 working days after sample acceptance.
Fasting Required
No
Method
PCR Sequencing, FISH, Flow cytometry
Step 1

Sample Collection

A duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory before sample collection. No fasting is required.

Method: Venipuncture and/or bone marrow aspiration

Step 2

Laboratory Analysis

Whole blood is collected from a vein in a lavender top EDTA tube. Bone marrow sample, if required, is collected by a specialist into green top sodium heparin tubes.

Step 3

Report Delivery

Keep samples at 18-22°C. Do not freeze. Send to the laboratory immediately.

Timeline: Reports are usually available within 5-7 working days after sample acceptance.

Patient Instructions

1
Before the Test:A duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory before sample collection. No fasting is required.
2
During the Test:Whole blood is collected from a vein in a lavender top EDTA tube. Bone marrow sample, if required, is collected by a specialist into green top sodium heparin tubes.
3
After the Test:Keep samples at 18-22°C. Do not freeze. Send to the laboratory immediately.

About This Test

Who Should Get This Test

The panel is used to identify genetic and immunophenotypic prognostic markers in CLL, including ZAP-70, CD38, CD49d, IGVH mutation status, del11q23 (ATM), del17p13.1 (TP53), del13q14.3, del13q34 and trisomy 12. These markers help estimate disease progression risk and guide treatment decisions.

How to Prepare

  • Collect 4 mL whole blood in 1 lavender top EDTA tube.
  • Collect 5 mL whole blood or 4 mL bone marrow in 2 green top sodium heparin tubes.
  • Mix tubes gently by inversion; do not freeze.
  • Ship at 18-22°C.
  • Ensure Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is sent with sample.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"This panel should always be interpreted with clinical and laboratory findings because CLL prognosis is multifactorial."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole blood or bone marrow
Sample Volume4 mL whole blood (2 mL min.) and 5 mL whole blood (3 mL min.) or 4 mL bone marrow (2 mL min.)
ContainerLavender top EDTA tube and green top sodium heparin tubes
Collection MethodVenipuncture and/or bone marrow aspiration

Sample Stability

Room temperature: 24 hours
Refrigerated: Not applicable
Frozen: Not applicable; do not freeze
Sample Rejection Criteria:
  • Frozen sample
  • Clotted or haemolysed sample
  • Inadequate sample volume
  • Missing or incomplete Chromosome & FISH analysis Requisition Form (Form 17)
  • Unlabelled or mislabelled specimen

Understanding Your Results

Results are reported as percentage expression or genetic abnormality status. Higher-risk features such as del17p/TP53 and del11q/ATM may indicate a more aggressive disease course, while isolated del13q14.3 is often favourable. All results should be correlated with clinical findings by a specialist.
ZAP-70: positive expression may be associated with more aggressive disease.
CD38 and CD49d: higher expression may suggest unfavourable prognosis.
IGVH mutation status: unmutated IGVH may be associated with faster progression.
del17p13.1 (TP53): high-risk marker; may affect treatment choice.
del11q23 (ATM): often associated with bulky disease and intermediate/high risk.
del13q14.3 as sole abnormality: relatively favourable.
Trisomy 12: intermediate prognosis.
del13q34: may be associated with adverse features.
⚠️ When to Consult a Doctor:

Consult a haematologist or oncologist if you have symptoms such as fatigue, weakness, swollen lymph nodes, fever, night sweats, weight loss or frequent infections, or if this panel shows high-risk markers.

Limitations

  • ⚠This test is not a standalone diagnostic test for CLL; it complements CBC, flow cytometry and bone marrow examination.
  • ⚠Prognostic marker patterns require correlation with clinical stage and performance status.
  • ⚠Rare genetic abnormalities not covered by the panel may still be present.

Risks & Considerations

  • ●Mild pain or bruising at venipuncture site
  • ●Slight bleeding or infection risk at bone marrow aspiration site
  • ●Rarely, lightheadedness during sample collection

Interfering Factors

  • ●Frozen sample
  • ●Clotted or haemolysed sample
  • ●Delayed transport or improper temperature
  • ●Recent chemotherapy or blood transfusion may affect results
  • ●Missing or incomplete mandatory Chromosome & FISH analysis Requisition Form (Form 17)

Frequently Asked Questions

What is the CLL Prognostic Panel Test?
It is a specialised test that evaluates genetic and immunophenotypic markers in chronic lymphocytic leukaemia cells to help predict disease progression and treatment response.
How much does the CLL Prognostic Panel Test cost at DNA Labs India?
The cost is INR 23,000.
What sample is required for this test?
4 mL whole blood in a lavender top EDTA tube and 5 mL whole blood or 4 mL bone marrow in green top sodium heparin tubes are required. The sample must not be frozen.
Is fasting required?
No fasting is required. However, a duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.
Which markers are included in the panel?
ZAP-70, CD38, CD49d, IGVH mutation status, del11q23 (ATM), del17p13.1 (TP53), del13q14.3, del13q34 and trisomy 12.
What methods are used for testing?
PCR sequencing, FISH and flow cytometry are used to evaluate the panel.
How long does it take to get reports?
Reports are generally available within 5-7 working days after sample acceptance.
Why is this test done?
It is done after a CLL diagnosis to stratify prognosis and guide treatment decisions.
Can I book home sample collection?
Yes, DNA Labs India offers free home sample collection for online bookings across many cities in India.
What do high-risk markers like del17p or TP53 mean?
They may indicate higher-risk CLL and can influence treatment planning. Results should be interpreted by an oncologist or haematologist.
Is this test available in all cities?
It is available in major cities including Mumbai, Delhi, Bangalore, Hyderabad, Chennai, Kolkata, Pune and many others.
Who should interpret the result?
A haematologist or oncologist should interpret the result in the context of clinical findings and other investigations.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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