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Chronic Neutrophilic Leukemia (CNL)(CSF3R Gene - Exon 14 & 17; SETBP Gene - Exon 4) Test

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Chronic Neutrophilic Leukemia (CNL)(CSF3R Gene - Exon 14 & 17; SETBP Gene - Exon 4) Test

Short Name: CNL Genetic Test

Also known as: Chronic Neutrophilic Leukemia Genetic Panel, CSF3R and SETBP1 Mutation Analysis

Chronic Neutrophilic Leukemia (CNL)(CSF3R Gene - Exon 14 & 17; SETBP Gene - Exon 4) Test test available at DNA Labs India for ₹12,000. Uses Sanger Sequencing on Bone Marrow/Peripheral Blood samples. Results in 7-8 days. Free home collection in 300+ cities across India.

Genetic TestAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this genetic test is to identify specific mutations in the CSF3R and SETBP genes associated with Chronic Neutrophilic Leukemia (CNL). It aids in confirming diagnosis, differentiating CNL from other myeloproliferative disorders, informing treatment strategies, and monitoring disease progression or response to therapy.

Test Code
2971
Price
₹12,000
Sample Type
Bone Marrow/Peripheral Blood
Result Time
7-8 days
Fasting Required
No
Method
Sanger Sequencing
Step 1

Sample Collection

No specific preparation is required. Inform your doctor about any medications, supplements, or recent medical procedures. Ensure proper identification documents are available.

Method: Bone Marrow Aspiration or Venipuncture

Step 2

Laboratory Analysis

A trained healthcare professional will collect the sample via venipuncture for peripheral blood or bone marrow aspiration, using sterile equipment and following standard protocols.

Step 3

Report Delivery

Apply pressure to the collection site to prevent bleeding. Monitor for any signs of infection or discomfort. Follow any additional instructions provided by the healthcare team.

Timeline: 7-8 days

Patient Instructions

1
Before the Test:No special preparation needed. Ensure a doctor's prescription is available, though it may not be required for certain cases like surgery or travel.
2
During the Test:Sample collection procedure as described; typically quick and minimally invasive.
3
After the Test:Wait for results within 7-8 days. Discuss findings with your doctor for next steps.

About This Test

Who Should Get This Test

The purpose of this genetic test is to identify specific mutations in the CSF3R and SETBP genes associated with Chronic Neutrophilic Leukemia (CNL). It aids in confirming diagnosis, differentiating CNL from other myeloproliferative disorders, informing treatment strategies, and monitoring disease progression or response to therapy.

How to Prepare

  • Verify patient identity and sample labeling
  • Use aseptic technique to prevent contamination
  • Collect sample in an EDTA vacutainer as specified
  • Transport sample at room temperature with a cool pack if needed
  • Ensure timely delivery to the laboratory

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This genetic test is essential for confirming CNL diagnosis, guiding treatment decisions, and monitoring disease progression."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBone Marrow/Peripheral Blood
Sample Volume2ml
ContainerEDTA Vacutainer
Collection MethodBone Marrow Aspiration or Venipuncture

Sample Stability

Stable for 24 hours at room temperature (15-25°C)
Refrigerate (2-8°C) if analysis is delayed beyond 24 hours
Avoid repeated freeze-thaw cycles
Sample Rejection Criteria:
  • Hemolyzed or clotted sample
  • Insufficient sample volume
  • Incorrect sample container or anticoagulant
  • Sample improperly labeled or unlabeled
  • Sample received beyond stability period

Understanding Your Results

Results from this genetic test indicate the presence or absence of specific mutations in the CSF3R and SETBP genes, which are biomarkers for Chronic Neutrophilic Leukemia (CNL). Positive results support a diagnosis of CNL, while negative results may require further clinical evaluation.
📊

Positive for CSF3R or SETBP mutation

Mutation detected, consistent with CNL diagnosis. Correlate with clinical symptoms and other tests for confirmation.

📊

Negative for mutations

No mutations detected in the tested exons. Consider other differential diagnoses and repeat testing if clinical suspicion remains high.

📊

Inconclusive

Results are unclear due to technical issues or low mutation levels. Repeat testing or additional genetic analysis may be recommended.

⚠️ When to Consult a Doctor:

Consult a hematologist or oncologist if you experience symptoms such as persistent fever, fatigue, weight loss, or enlarged spleen, especially if genetic test results are positive or inconclusive. Regular follow-up is advised for monitoring.

Limitations

  • ⚠This test may not detect all rare or novel mutations in CSF3R or SETBP genes
  • ⚠Results should be interpreted in conjunction with clinical findings and other diagnostic tests
  • ⚠False negatives are possible if mutation levels are below detection threshold

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Rare risk from bone marrow aspiration, including bleeding or discomfort
  • ●No significant genetic risks from the test itself

Interfering Factors

  • ●Sample contamination during collection or transport
  • ●Improper storage conditions affecting DNA integrity
  • ●Recent blood transfusions may alter genetic material
  • ●Use of certain medications that affect blood cell counts

Compare With Similar Tests

TestChronic Neutrophilic Leukemia (CNL)(CSF3R Gene - Exon 14 & 17; SETBP Gene - Exon 4)Complete Blood Count (CBC)Bone Marrow BiopsyFlow Cytometry
ComparisonChronic Neutrophilic Leukemia (CNL)(CSF3R Gene - Exon 14 & 17; SETBP Gene - Exon 4)CBC measures blood cell counts but cannot detect specific genetic mutations; this test provides molecular confirmation.Biopsy assesses cell morphology; genetic testing adds precision by identifying underlying mutations.Flow cytometry analyzes cell surface markers; genetic testing targets DNA mutations for definitive diagnosis.

Frequently Asked Questions

What is Chronic Neutrophilic Leukemia (CNL)?
CNL is a rare blood cancer characterized by the overproduction of neutrophils, a type of white blood cell, leading to various symptoms and health complications.
What genes are tested in this CNL genetic test?
This test analyzes mutations in the CSF3R gene (exons 14 and 17) and the SETBP gene (exon 4), which are commonly associated with CNL.
Why is genetic testing important for CNL diagnosis?
Genetic testing confirms the presence of specific mutations, helping to differentiate CNL from other similar conditions and guide personalized treatment plans.
What are the common symptoms of CNL?
Symptoms include fever, fatigue, weight loss, night sweats, enlarged spleen or liver, and bone or joint pain, though they can vary among individuals.
How is the sample collected for this test?
The sample is collected via venipuncture for peripheral blood or bone marrow aspiration, using an EDTA vacutainer, and can be done at home or a clinic.
Is fasting required before the test?
No, fasting is not required for this genetic test. You can eat and drink normally before sample collection.
How long does it take to get the results?
Results are typically available within 7-8 days after sample collection, and can be accessed online, via email, or WhatsApp.
What does a positive result mean?
A positive result indicates the detection of mutations in CSF3R or SETBP genes, supporting a diagnosis of CNL. Consult your doctor for further evaluation and treatment.
What if the test result is negative?
A negative result means no mutations were detected in the tested exons. However, if symptoms persist, further clinical assessment or repeat testing may be needed.
Is home sample collection available for this test?
Yes, free home sample collection is offered for online bookings across many cities in India, including Mumbai, Delhi, Bangalore, and others.
What is the cost of the CNL genetic test in India?
The approximate cost is INR 12,000, which may vary slightly by location. This includes sample collection, analysis, and report generation.
Are there any risks associated with this test?
The test involves minimal risks, such as bruising from blood draw or discomfort from bone marrow aspiration, but serious complications are rare.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

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