Cytochrome P450 2C19 Genotyping (CYP2C19) Clopidogrel Resistance (*2,*3,*4,*10) Test
Short Name: CYP2C19 Genotyping
Also known as: CYP2C19 Genotyping, Clopidogrel Resistance Test, Plavix Resistance Test, CYP2C19 Pharmacogenomic Test, Antiplatelet Resistance Genetic Test
Cytochrome P450 2C19 Genotyping (CYP2C19) Clopidogrel Resistance (*2,*3,*4,*10) Test test available at DNA Labs India for ₹6,000. Uses Sanger Sequencing on Peripheral Blood samples. Results in Reports are typically available within 7 working days from the date of sample collection. Results will be delivered via online portal, email, or WhatsApp as per your preference.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The primary purpose of CYP2C19 genotyping is to identify individuals who may not respond adequately to clopidogrel therapy due to genetic variations in the CYP2C19 gene. This test helps clinicians personalize antiplatelet therapy by identifying poor and intermediate metabolizers who may benefit from alternative medications such as prasugrel or ticagrelor. It is particularly valuable for patients undergoing coronary stent placement, those with acute coronary syndromes, and individuals with a history of recurrent cardiovascular events while on clopidogrel. Early identification of clopidogrel resistance can prevent life-threatening complications such as stent thrombosis, myocardial infarction, and ischemic stroke.
- Test Code
- 2991
- CPT Code
- 81225
- ICD Code
- Z13.89
- Price
- ₹6,000
- Sample Type
- Peripheral Blood
- Result Time
- Reports are typically available within 7 working days from the date of sample collection. Results will be delivered via online portal, email, or WhatsApp as per your preference.
- Fasting Required
- No
- Method
- Sanger Sequencing
Sample Collection
A doctor's prescription may be required for this test. Prescription is not applicable for surgery, pregnancy cases, or individuals planning to travel abroad. No fasting is required. Inform your physician about any current medications, recent blood transfusions, or bone marrow transplant history.
Method: Venipuncture
Laboratory Analysis
A trained phlebotomist will collect approximately 2 ml of peripheral blood via venipuncture into an EDTA vacutainer. The procedure typically takes 5 to 10 minutes. The sample will be labeled, stored with a cool pack, and transported to the laboratory under controlled conditions.
Report Delivery
Apply gentle pressure to the puncture site with a sterile cotton ball for 3 to 5 minutes. You may resume normal activities immediately. Avoid heavy lifting with the punctured arm for a few hours. Results will be available within 7 working days via online portal, email, or WhatsApp.
Timeline: Reports are typically available within 7 working days from the date of sample collection. Results will be delivered via online portal, email, or WhatsApp as per your preference.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of CYP2C19 genotyping is to identify individuals who may not respond adequately to clopidogrel therapy due to genetic variations in the CYP2C19 gene. This test helps clinicians personalize antiplatelet therapy by identifying poor and intermediate metabolizers who may benefit from alternative medications such as prasugrel or ticagrelor. It is particularly valuable for patients undergoing coronary stent placement, those with acute coronary syndromes, and individuals with a history of recurrent cardiovascular events while on clopidogrel. Early identification of clopidogrel resistance can prevent life-threatening complications such as stent thrombosis, myocardial infarction, and ischemic stroke.
How to Prepare
- No fasting is required for this genetic test
- Bring a valid photo ID and doctor's prescription if applicable
- Inform the phlebotomist about any blood-thinning medications you are currently taking
- Disclose any recent blood transfusions or bone marrow transplant history
- Sample will be collected in an EDTA vacutainer (2 ml) and transported with a cool pack
- Wear loose-fitting sleeves to allow easy access to the arm for blood draw
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"As a cardiologist, I routinely encounter patients who do not achieve adequate platelet inhibition with standard clopidogrel therapy. CYP2C19 genotyping is an invaluable tool that allows us to identify poor and intermediate metabolizers before initiating or adjusting antiplatelet therapy. For patients found to carry loss-of-function alleles such as *2 or *3, I recommend alternative agents like prasugrel or ticagrelor, which do not rely on CYP2C19 for activation. This pharmacogenomic approach has significantly improved outcomes in my practice, particularly for patients undergoing percutaneous coronary intervention (PCI) and those with acute coronary syndromes. I strongly recommend this test for any patient with a history of stent thrombosis or recurrent cardiovascular events while on clopidogrel."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed sample
- Insufficient sample volume (less than 1 ml)
- Clotted sample
- Unlabeled or mislabeled sample
- Sample collected in incorrect container (non-EDTA tube)
- Sample received without proper documentation or requisition form
Understanding Your Results
Normal Metabolizer (NM) — *1/*1
Low risk of clopidogrel resistance due to CYP2C19 genotype.
Intermediate Metabolizer (IM) — *1/*2, *1/*3, *1/*4, *1/*10
Moderately increased risk of reduced clopidogrel response and adverse cardiovascular events.
Poor Metabolizer (PM) — *2/*2, *2/*3, *3/*3, *2/*4, *3/*4
High risk of clopidogrel treatment failure, stent thrombosis, and recurrent cardiovascular events.
Rapid Metabolizer (RM) — *1/*17
Generally favorable response to clopidogrel; standard dosing is effective.
Ultrarapid Metabolizer (UM) — *17/*17
Enhanced clopidogrel activation; monitor for excessive antiplatelet effect and bleeding.
Consult your physician if you experience recurrent cardiovascular events such as chest pain, shortness of breath, or stroke-like symptoms while taking clopidogrel. You should also consult your doctor if you are scheduled for a percutaneous coronary intervention (PCI), have a history of stent thrombosis, or have a family history of clopidogrel resistance. Your cardiologist may recommend this test to optimize your antiplatelet therapy and reduce the risk of adverse cardiovascular outcomes.
Limitations
- ⚠This test detects only the specified variants (*2, *3, *4, *10) and does not cover all possible CYP2C19 gene variants
- ⚠Rare or novel variants not included in the panel will not be detected
- ⚠Results should be interpreted in conjunction with clinical findings and other laboratory data
- ⚠Genetic testing cannot predict the exact clinical outcome of clopidogrel therapy with certainty
- ⚠Environmental factors, drug-drug interactions, and comorbidities may also influence clopidogrel response independently of genotype
- ⚠This test does not assess platelet function directly; functional platelet testing may be needed for comprehensive evaluation
Risks & Considerations
- ●Minor bruising or hematoma at the blood draw site
- ●Slight risk of infection at the venipuncture puncture site
- ●Temporary lightheadedness or dizziness during or after blood collection
- ●Rarely, excessive bleeding in individuals on anticoagulant therapy
Interfering Factors
- ●Hemolyzed blood samples may affect DNA extraction quality and genotyping accuracy
- ●Recent blood transfusion (within 4 weeks) may introduce donor DNA and interfere with results
- ●Bone marrow transplant recipients may show donor DNA profile rather than recipient genotype
- ●Sample contamination during collection or transport may compromise results
- ●Concurrent use of certain medications does not typically affect genotyping but should be disclosed
Compare With Similar Tests
| Test | Cytochrome P450 2C19 Genotyping (CYP2C19) Clopidogrel Resistance (*2,*3,*4,*10) | |||||
|---|---|---|---|---|---|---|
| Comparison | Cytochrome P450 2C19 Genotyping (CYP2C19) Clopidogrel Resistance (*2,*3,*4,*10) |
Frequently Asked Questions
What is CYP2C19 genotyping?
Why is CYP2C19 genotyping important for clopidogrel therapy?
Who should get tested for CYP2C19 variants?
What is clopidogrel resistance?
How is the CYP2C19 genotyping test performed?
What do the test results mean?
Is fasting required for this test?
How long does it take to get the results?
What is the cost of CYP2C19 genotyping at DNA Labs India?
Is home sample collection available for this test?
What should I do if I am a poor metabolizer?
Can this test be performed while I am taking clopidogrel?
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