HLA Hypersensitivity to Carbamazepine & Phenytoin (B*15:02) Test
Short Name: HLA B*15:02 Test
Also known as: HLA-B*15:02 Genotyping, Carbamazepine Hypersensitivity Test, Phenytoin Hypersensitivity Test, SJS/TEN Risk Test
HLA Hypersensitivity to Carbamazepine & Phenytoin (B*15:02) Test test available at DNA Labs India for ₹8,000. Uses PCR, Sequencing on Whole blood or Buccal swab samples. Results in 10-12 days. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify individuals carrying the HLA-B*15:02 allele who are at increased risk of developing severe hypersensitivity reactions, such as SJS/TEN, when taking carbamazepine or phenytoin. This enables proactive medication selection to avoid life-threatening adverse effects.
- Test Code
- 814
- CPT Code
- 81381
- ICD Code
- L27.1
- Price
- ₹8,000
- Sample Type
- Whole blood or Buccal swab
- Result Time
- 10-12 days
- Fasting Required
- No
- Method
- PCR, Sequencing
Sample Collection
No special preparation required. Inform the healthcare provider about any medications or recent transfusions.
Method: Blood draw or Buccal swab collection
Laboratory Analysis
A blood sample will be drawn from a vein in the arm using a needle, or a buccal swab will be collected by rubbing the inside of the cheek. The procedure is quick and minimally invasive.
Report Delivery
Apply pressure to the blood collection site to prevent bruising. Resume normal activities immediately. For buccal swabs, avoid eating or drinking for 30 minutes prior.
Timeline: 10-12 days
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify individuals carrying the HLA-B*15:02 allele who are at increased risk of developing severe hypersensitivity reactions, such as SJS/TEN, when taking carbamazepine or phenytoin. This enables proactive medication selection to avoid life-threatening adverse effects.
How to Prepare
- For blood collection: Clean the site with antiseptic, draw 4-6 mL blood into specified tube
- For buccal swab: Rub the swab firmly against the inner cheek for 30 seconds
- Label samples correctly with patient details
- Ship refrigerated; do not freeze
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This test is critical for patients initiating or currently on carbamazepine or phenytoin to prevent potentially fatal skin reactions like SJS/TEN. Early identification of HLA-B*15:02 carriers allows for safer medication alternatives."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Incorrect sample type or container
- Samples hemolyzed, clotted, or insufficient volume
- Improper labeling or storage conditions
- Leaking or damaged containers
Understanding Your Results
HLA-B*15:02 Detected
Positive result indicates an increased risk of developing SJS/TEN when exposed to carbamazepine or phenytoin. Avoid use of these drugs and consult a healthcare provider for alternative treatments.
Action: Discuss medication alternatives with your doctor.
HLA-B*15:02 Not Detected
Negative result suggests a lower risk, but not zero risk, of hypersensitivity reactions. Standard precautions should still be taken.
Action: Monitor for any adverse symptoms during drug therapy.
If you test positive for HLA-B*15:02, consult your doctor immediately to review your medication regimen. Also, seek medical attention if you experience symptoms like skin rash, fever, or blistering while taking carbamazepine or phenytoin.
Limitations
- ⚠This test only screens for HLA-B*15:02 and not other HLA alleles associated with drug hypersensitivity
- ⚠A negative result does not entirely eliminate the risk of adverse reactions
- ⚠Results should be interpreted in conjunction with clinical history and other diagnostic findings
Risks & Considerations
- ●Minor bruising or discomfort at blood draw site
- ●Rare risk of infection or fainting during blood collection
- ●No significant risks from buccal swab collection
Interfering Factors
- ●Hemolyzed or lipemic blood samples may affect DNA extraction
- ●Recent blood transfusions could lead to false results
- ●Improper sample collection or storage
Compare With Similar Tests
| Test | HLA Hypersensitivity to Carbamazepine & Phenytoin (B*15:02) Test | HLA-A*31:01 Test |
|---|---|---|
| Comparison | HLA Hypersensitivity to Carbamazepine & Phenytoin (B*15:02) Test |
Frequently Asked Questions
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