Cytochrome P450 2D6 Genotyping (CYP2D6 - Alleles) Test
Short Name: CYP2D6 Genotyping
Also known as: CYP2D6 Genotyping, Pharmacogenomic Test
Cytochrome P450 2D6 Genotyping (CYP2D6 - Alleles) Test test available at DNA Labs India for ₹6,750. Uses Sanger Sequencing on Peripheral blood samples. Results in 10-12 days. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
To determine an individual's CYP2D6 genotype for predicting drug metabolism and response, aiding in personalized medication management and reducing the risk of adverse drug reactions.
- Test Code
- 2986
- Price
- ₹6,750
- Sample Type
- Peripheral blood
- Result Time
- 10-12 days
- Fasting Required
- No
- Method
- Sanger Sequencing
Sample Collection
Ensure a doctor's prescription is available. No fasting is required. Bring a valid ID and the prescription to the collection center.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn from a vein in the arm using a needle and EDTA vacutainer. The process takes about 5-10 minutes.
Report Delivery
Apply pressure to the puncture site with a cotton ball to prevent bleeding. Avoid heavy lifting with the arm for a few hours.
Timeline: 10-12 days
Patient Instructions
About This Test
Who Should Get This Test
To determine an individual's CYP2D6 genotype for predicting drug metabolism and response, aiding in personalized medication management and reducing the risk of adverse drug reactions.
How to Prepare
- Bring a valid ID and doctor's prescription
- Wear loose clothing for easy access to the arm
- Inform the phlebotomist of any bleeding disorders or medications
- Stay hydrated before the test if possible
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"As a gynecologist, I recommend CYP2D6 genotyping for patients on medications metabolized by this enzyme to optimize treatment and reduce side effects, especially in reproductive health contexts."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted sample
- Insufficient sample volume (<2ml)
- Incorrect container or labeling
- Sample older than 48 hours
Understanding Your Results
Two non-functional alleles; high risk of side effects or toxicity from standard doses; consider dose reduction or alternative drugs.
One functional and one non-functional allele; may require dose adjustments; monitor for efficacy and side effects.
Two functional alleles; normal metabolism; standard dosing typically appropriate.
Multiple functional alleles; rapid drug clearance; may require higher doses or alternative medications for efficacy.
Consult your doctor if you experience unexpected side effects, if medications are not working as expected, or before starting new medications metabolized by CYP2D6 after genotyping.
Limitations
- ⚠May not detect all rare or novel CYP2D6 variants
- ⚠Does not account for environmental factors or drug interactions
- ⚠Results should be interpreted in conjunction with clinical history and other tests
Risks & Considerations
- ●Minor bruising or pain at the puncture site
- ●Rare risk of infection or dizziness
- ●No significant long-term risks associated with the genetic test itself
Interfering Factors
- ●Sample contamination or degradation
- ●DNA extraction issues
- ●Technical errors in Sanger sequencing
- ●Presence of inhibitors in the sample
Compare With Similar Tests
| Test | Cytochrome P450 2D6 Genotyping (CYP2D6 - Alleles) | CYP2C19 Genotyping | CYP2C9 Genotyping | Thiopurine Methyltransferase (TPMT) Genotyping | Pharmacogenomic Panel |
|---|---|---|---|---|---|
| Comparison | Cytochrome P450 2D6 Genotyping (CYP2D6 - Alleles) | Similar genetic test for CYP2C19 enzyme, affecting drugs like clopidogrel and proton pump inhibitors. | Focuses on CYP2C9 enzyme, important for warfarin metabolism and dosing. | Tests for TPMT enzyme, relevant for thiopurine drugs used in autoimmune diseases and cancer. | Comprehensive panel testing multiple genes for broader drug metabolism insights. |
Frequently Asked Questions
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