E2A t(1;19)(q23;p13) Qualitative Test
Short Name: E2A t(1;19) Qualitative
Also known as: t(1;19) translocation, E2A-PBX1 fusion, TCF3-PBX1 rearrangement
E2A t(1;19)(q23;p13) Qualitative Test test available at DNA Labs India for ₹4,500. Uses Real Time PCR on Bone marrow / Peripheral blood samples. Results in Reports are typically available within 3-4 days after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to detect the E2A-PBX1 fusion gene resulting from the t(1;19) translocation. This helps in confirming the diagnosis of ALL, assessing prognosis, and guiding targeted therapy. It is also used for monitoring minimal residual disease (MRD) in patients undergoing treatment.
- Test Code
- 6096
- CPT Code
- 81105
- ICD Code
- C91.00
- Price
- ₹4,500
- Sample Type
- Bone marrow / Peripheral blood
- Result Time
- Reports are typically available within 3-4 days after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- Real Time PCR
Sample Collection
No special preparation required. A doctor's prescription is needed. Inform your physician about any ongoing medications or treatments.
Method: Venipuncture or bone marrow aspiration
Laboratory Analysis
Blood sample will be collected by a trained phlebotomist using sterile technique. For bone marrow, the procedure is performed by a specialist under local anesthesia.
Report Delivery
You may resume normal activities immediately. For bone marrow, follow post-procedure care instructions provided by your doctor.
Timeline: Reports are typically available within 3-4 days after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to detect the E2A-PBX1 fusion gene resulting from the t(1;19) translocation. This helps in confirming the diagnosis of ALL, assessing prognosis, and guiding targeted therapy. It is also used for monitoring minimal residual disease (MRD) in patients undergoing treatment.
How to Prepare
- Use EDTA vacutainer for blood collection
- Transport immediately to the laboratory at 2-8°C
- Do not freeze the sample
- Label the sample with patient details and date/time of collection
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Early detection of the E2A-PBX1 translocation is critical for risk stratification in ALL. This qualitative test provides rapid and reliable results to guide treatment decisions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or hemolyzed sample
- Incorrect container (e.g., heparin tube)
- Sample older than 48 hours without proper storage
- Unlabeled or mislabeled sample
Understanding Your Results
Not Detected
No evidence of E2A-PBX1 fusion; other genetic abnormalities may be considered.
Detected
Presence of t(1;19) translocation; indicates a distinct ALL subtype with prognostic implications. Treatment may be adjusted accordingly.
Consult your oncologist or hematologist if you have symptoms such as persistent fever, unexplained bruising, bone pain, or if you have been diagnosed with ALL and need genetic testing for risk stratification.
Limitations
- ⚠Qualitative test does not quantify the level of fusion transcript
- ⚠May not detect rare variant translocations
- ⚠Requires high-quality RNA; degraded samples may yield false negatives
- ⚠Clinical correlation with other diagnostic tests is essential
Risks & Considerations
- ●Minimal risk of bruising or bleeding at the puncture site
- ●Rare risk of infection at the collection site
- ●For bone marrow: rare risk of bleeding, infection, or discomfort
Interfering Factors
- ●Hemolysis or clotting of blood sample
- ●Inadequate sample volume
- ●Delayed transport leading to RNA degradation
- ●Contamination during sample processing
Compare With Similar Tests
| Test | E2A t(1;19)(q23;p13) Qualitative | BCR-ABL t(9;22) Qualitative | MLL (KMT2A) Rearrangement | TEL-AML1 t(12;21) Qualitative |
|---|---|---|---|---|
| Comparison | E2A t(1;19)(q23;p13) Qualitative |
Frequently Asked Questions
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