ELAC2 Gene Prostate cancer, hereditary type 2, susceptibility to NGS Genetic Test
Short Name: ELAC2 NGS Prostate Cancer
Also known as: ELAC2 Gene Mutation Test, Hereditary Prostate Cancer Panel, Prostate Cancer Genetic Susceptibility Test
ELAC2 Gene Prostate cancer, hereditary type 2, susceptibility to NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify mutations in the ELAC2 gene that increase the risk of hereditary prostate cancer type 2. It is recommended for individuals with a family history of prostate cancer, especially those with multiple affected relatives, early-onset disease, or a known familial mutation. The test helps in risk stratification, guiding screening protocols, and enabling informed decisions about preventive measures.
- Test Code
- 6020
- CPT Code
- 81435
- ICD Code
- Z15.03
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 weeks
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No fasting required. Please provide clinical history and family pedigree. A genetic counseling session is recommended before the test.
Method: Venipuncture or Fingerstick
Laboratory Analysis
Blood sample will be collected by a trained phlebotomist. For FTA card, a fingerstick blood drop is applied to the card.
Report Delivery
No special precautions. You can resume normal activities immediately.
Timeline: 3 to 4 weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify mutations in the ELAC2 gene that increase the risk of hereditary prostate cancer type 2. It is recommended for individuals with a family history of prostate cancer, especially those with multiple affected relatives, early-onset disease, or a known familial mutation. The test helps in risk stratification, guiding screening protocols, and enabling informed decisions about preventive measures.
How to Prepare
- Ensure the sample is collected in an EDTA tube or on an FTA card as provided.
- Label the sample with patient ID and date of collection.
- For FTA card, allow the blood spot to air dry completely before packaging.
- Transport the sample to the laboratory at ambient temperature.
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"Genetic testing for ELAC2 mutations is crucial for men with a strong family history of prostate cancer. Early identification can guide screening and preventive strategies."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed blood sample
- Clotted blood sample (if EDTA tube not mixed properly)
- Insufficient sample volume
- Sample received after prolonged transit time (>72 hours) without proper storage
- FTA card with insufficient blood spots or contamination
Understanding Your Results
Pathogenic variant detected
Increased risk for hereditary prostate cancer type 2. Recommend enhanced screening and preventive strategies.
Action: Consult with oncologist and genetic counselor for personalized management.
Variant of uncertain significance (VUS)
The clinical significance is unknown. May require further family segregation analysis.
Action: Genetic counseling and possible additional testing for family members.
No pathogenic variant detected
No increased risk identified from the tested genes. However, hereditary risk from other genes cannot be ruled out.
Action: Continue standard prostate cancer screening as per age and risk factors.
Consult your doctor if you have a family history of prostate cancer, experience urinary symptoms, or have been advised genetic testing by a specialist. Early consultation can help in timely screening and risk management.
Limitations
- ⚠This test does not detect all genetic causes of hereditary prostate cancer; other genes may be involved.
- ⚠Variants of uncertain significance (VUS) may be reported; interpretation may require further family studies.
- ⚠Negative result does not rule out hereditary risk due to unknown genes.
- ⚠Test is not intended for diagnosis of prostate cancer; it is for susceptibility assessment.
- ⚠Results should be interpreted in the context of clinical and family history.
Risks & Considerations
- ●Minimal risk of bruising or bleeding at the puncture site
- ●Rare risk of infection
- ●Psychological impact of genetic results
Interfering Factors
- ●Contamination of sample during collection
- ●Insufficient DNA quantity or quality
- ●Presence of hematologic malignancies affecting DNA extraction
- ●Recent blood transfusion (within 2 weeks) may dilute DNA
- ●Use of anticoagulants other than EDTA
Compare With Similar Tests
| Test | ELAC2 Gene Prostate cancer, hereditary type 2, susceptibility to NGS Genetic Test | Single Gene ELAC2 Test | BRCA1/BRCA2 Only Test |
|---|---|---|---|
| Comparison | ELAC2 Gene Prostate cancer, hereditary type 2, susceptibility to NGS Genetic Test | This NGS panel includes ELAC2 and multiple other genes, providing a comprehensive risk assessment. Single gene tests are less comprehensive and may miss mutations in other associated genes. | While BRCA mutations are important, this panel also covers ELAC2, HOXB13, and ATM, offering a broader evaluation of hereditary prostate cancer risk. |
Frequently Asked Questions
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