Eosinophilic Leukemia Panel (FISH PDGFRA,PDGFRB,FGFR1,C BFB) Test
Short Name: Eosinophilic Leukemia Panel
Also known as: FISH PDGFRA/PDGFRB/FGFR1/C BFB Panel, Eosinophilic Leukemia FISH Panel
Eosinophilic Leukemia Panel (FISH PDGFRA,PDGFRB,FGFR1,C BFB) Test test available at DNA Labs India for ₹20,250. Uses Fluorescence In Situ Hybridization (FISH) on Bone marrow / Peripheral blood samples. Results in Results are typically available within 3-4 days after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of this FISH panel is to detect chromosomal rearrangements in the PDGFRA, PDGFRB, FGFR1, and C BFB genes, which are frequently associated with eosinophilic leukemia. Identifying these genetic markers helps confirm the diagnosis, differentiate from reactive eosinophilia, guide targeted therapy, and monitor disease progression.
- Test Code
- 6099
- CPT Code
- 88271; 88275; 88291
- ICD Code
- C94.4
- Price
- ₹20,250
- Sample Type
- Bone marrow / Peripheral blood
- Result Time
- Results are typically available within 3-4 days after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- Fluorescence In Situ Hybridization (FISH)
Sample Collection
No fasting required. Inform your doctor about any medications, especially tyrosine kinase inhibitors. A doctor's prescription is mandatory for this test.
Method: Venipuncture / Bone marrow aspiration
Laboratory Analysis
Peripheral blood sample will be collected via venipuncture. For bone marrow, a local anesthetic will be applied. The procedure takes about 15-20 minutes.
Report Delivery
You may resume normal activities. For bone marrow aspiration, keep the site clean and dry for 24 hours. Report any unusual bleeding or pain.
Timeline: Results are typically available within 3-4 days after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this FISH panel is to detect chromosomal rearrangements in the PDGFRA, PDGFRB, FGFR1, and C BFB genes, which are frequently associated with eosinophilic leukemia. Identifying these genetic markers helps confirm the diagnosis, differentiate from reactive eosinophilia, guide targeted therapy, and monitor disease progression.
How to Prepare
- Use Sodium Heparin Vacutainer (2 ml) for peripheral blood
- Transport immediately to the laboratory at room temperature (cool pack if delay)
- Do not refrigerate or freeze the sample
- Label the sample with patient name, date, and time of collection
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This FISH panel is essential for identifying specific gene rearrangements that guide targeted therapy in eosinophilic leukemia. Early detection improves prognosis."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted sample
- Hemolyzed sample
- Incorrect anticoagulant (e.g., EDTA)
- Sample older than 48 hours
- Unlabeled or mislabeled sample
Understanding Your Results
PDGFRA rearrangement positive
Indicates response to imatinib; associated with chronic eosinophilic leukemia
PDGFRB rearrangement positive
Also responsive to imatinib; often seen with t(5;12)
FGFR1 rearrangement positive
Associated with aggressive myeloid/lymphoid neoplasms; may require stem cell transplant
C BFB rearrangement positive
Rare; may indicate poor prognosis; targeted therapy options limited
All negative
No known rearrangements detected; consider other causes of eosinophilia
Consult a hematologist or oncologist if you have persistent eosinophilia, unexplained symptoms like fever, weight loss, night sweats, or organ dysfunction. Early referral is crucial for timely diagnosis and treatment.
Limitations
- ⚠FISH only detects specific known rearrangements; other genetic abnormalities may be missed
- ⚠Low-level mosaicism may not be detected
- ⚠Results should be interpreted in conjunction with clinical and morphological findings
- ⚠Not a standalone diagnostic test; requires correlation with blood counts and bone marrow biopsy
Risks & Considerations
- ●Bruising or bleeding at the puncture site
- ●Infection (rare)
- ●Discomfort during bone marrow aspiration
Interfering Factors
- ●Recent blood transfusion may dilute abnormal cells
- ●Inadequate sample volume or clotted sample
- ●Delayed transport leading to cell degradation
- ●Prior chemotherapy or targeted therapy may reduce abnormal clone
- ●Bone marrow fibrosis may affect cell yield
Compare With Similar Tests
| Test | Eosinophilic Leukemia Panel (FISH PDGFRA,PDGFRB,FGFR1,C BFB) | Complete Blood Count (CBC) with Differential | Bone Marrow Biopsy | Conventional Cytogenetics (Karyotype) | Next-Generation Sequencing (NGS) |
|---|---|---|---|---|---|
| Comparison | Eosinophilic Leukemia Panel (FISH PDGFRA,PDGFRB,FGFR1,C BFB) |
Frequently Asked Questions
What is the cost of the Eosinophilic Leukemia Panel FISH test?
What sample is required for this test?
Do I need to fast before the test?
How long does it take to get results?
Is a doctor's prescription necessary?
What does FISH stand for?
Which genes are tested in this panel?
Can this test be done during pregnancy?
Is home sample collection available?
What is the significance of PDGFRA rearrangement?
Are there any risks associated with bone marrow collection?
How should the sample be transported?
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