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F5 Gene Budd-Chiari Syndrome NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

F5 Gene Budd-Chiari Syndrome NGS Genetic Test

Short Name: F5 Gene BCS NGS

Also known as: Factor V NGS Mutation Panel, F5 Gene Thrombophilia NGS Test, Budd-Chiari Syndrome F5 Genetic Test

F5 Gene Budd-Chiari Syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

The purpose of this genetic test is to detect F5 gene mutations that increase the risk of blood clotting and may be associated with Budd-Chiari syndrome. The result helps the treating clinician identify a possible inherited cause of hepatic vein thrombosis, guide anticoagulation management, and support screening of at-risk family members.

Test Code
3942
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No fasting is required. The doctor may ask for a genetic counseling session before the test. Please inform us about your current medications, especially anticoagulants, and any history of blood transfusion or bone marrow transplant.

Method: Venipuncture / finger-prick FTA spot

Step 2

Laboratory Analysis

A small volume of blood is drawn from a vein in your arm. For FTA cards, a drop of blood is collected from a finger prick. The procedure is simple and takes only a few minutes.

Step 3

Report Delivery

You can resume normal daily activities. There are no restrictions. The sample must be transported to the laboratory as per the validated shipping protocol.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:No fasting is required. A genetic counselling session may be requested before the test to draw a family pedigree chart. Please inform the laboratory about anticoagulant use or any history of bone marrow transplant.
2
During the Test:A trained phlebotomist will collect a small blood sample. If the FTA card method is used, a simple finger-prick spot is collected. The procedure is quick and safe.
3
After the Test:You can return to routine activities immediately. No dietary restriction or prolonged observation is needed.

About This Test

Who Should Get This Test

The purpose of this genetic test is to detect F5 gene mutations that increase the risk of blood clotting and may be associated with Budd-Chiari syndrome. The result helps the treating clinician identify a possible inherited cause of hepatic vein thrombosis, guide anticoagulation management, and support screening of at-risk family members.

How to Prepare

  • No fasting is required.
  • Complete the genetic counseling session or pedigree chart before booking, if advised.
  • Ensure correct patient identification details are written on the sample container.
  • For home collection, keep your FTA card or EDTA tube ready when the phlebotomist arrives.

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"If a pathogenic F5 variant is identified, one should not stop or start anticoagulants without coordinated advice from a hematologist. In women, estrogen-containing oral contraceptives and pregnancy can further increase thrombosis risk; women should receive tailored preconception counselling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs per laboratory protocol
ContainerEDTA vacutainer / FTA card / sterile DNA tube
Collection MethodVenipuncture / finger-prick FTA spot

Sample Stability

EDTA whole blood48-72 hours after collection
FTA spotStable during transit
Extracted DNALong-term storage
Sample Rejection Criteria:
  • Clotted or hemolysed sample
  • Insufficient DNA quantity after extraction
  • Improperly labelled sample
  • Sample received in a non-approved container
  • FTA card not dried before packing

Understanding Your Results

Interpretation should be performed by a qualified geneticist or physician. Variant classification follows international standards such as ACMG/AMP guidelines. The genetic finding is one part of the clinical picture.
📊

Indicates an inherited thrombophilia risk and supports a possible genetic contribution to Budd-Chiari syndrome or other venous thromboembolic disease.

📊

Reduces the likelihood of F5-related thrombophilia but does not exclude all inherited or acquired causes of Budd-Chiari syndrome.

📊

The clinical significance is unknown; additional family studies or functional evidence may be needed before using this variant in clinical decisions.

⚠️ When to Consult a Doctor:

If you have symptoms of liver disease, such as abdominal pain, abdominal swelling, jaundice, or unexplained leg swelling, seek medical attention. If the test result is positive or uncertain, schedule a follow-up with a hepatologist, hematologist, or clinical geneticist.

Limitations

  • ⚠This test analyzes only the F5 gene and does not exclude mutations in other genes associated with Budd-Chiari syndrome.
  • ⚠A negative result does not rule out acquired causes of thrombophilia or hepatic vein thrombosis.
  • ⚠NGS may not reliably detect large gene rearrangements or deep intronic variants in all cases.
  • ⚠Variants of uncertain significance may require additional family studies or functional analysis.
  • ⚠Budd-Chiari syndrome cannot be diagnosed by genetic testing alone; imaging and clinical correlation are essential.

Risks & Considerations

  • ●Minor bleeding or bruising at the venipuncture site
  • ●Dizziness or light-headedness during blood collection
  • ●Rare local infection at the puncture site

Interfering Factors

  • ●Insufficient DNA quantity or quality
  • ●Contamination or sample mix-up
  • ●Recent allogenic bone marrow transplant may affect DNA test results
  • ●Very low-level mosaic variants may fall below the NGS detection threshold

Compare With Similar Tests

TestF5 Gene Budd-Chiari Syndrome NGS Genetic Test
ComparisonF5 Gene Budd-Chiari Syndrome NGS Genetic Test

Frequently Asked Questions

What is the F5 Gene Budd-Chiari Syndrome NGS Genetic Test?
It is a targeted next-generation sequencing test that analyzes the F5 gene to detect mutations that may increase the risk of Budd-Chiari syndrome and other venous clotting disorders.
What is the cost of the F5 gene NGS test at DNA Labs India?
The F5 Gene Budd-Chiari Syndrome NGS Genetic Test is priced at Rs 20000 at DNA Labs India. Online bookings include free home sample collection in many cities across India.
Who should undergo this test?
It may be recommended for individuals with unexplained Budd-Chiari syndrome, recurrent or unprovoked clotting, first-degree relatives of known F5 mutation carriers, and patients with a strong personal or family history of venous thromboembolism.
What sample is needed for the F5 gene NGS test?
The test can be performed on blood collected in an EDTA tube, extracted DNA, or one drop of blood spotted on an FTA card. The appropriate sample should be confirmed with DNA Labs India before collection.
Is fasting required before the F5 gene test?
No, fasting is not required. You can eat and drink normally unless the ordering doctor has asked you to fast for simultaneous tests.
What does the test look for?
It uses next-generation sequencing to detect mutations or variants in the F5 gene, including the Factor V Leiden variant, that are associated with increased thrombotic risk.
How long does it take to get the report?
The report is generally delivered in 3 to 4 weeks after the sample is received by the laboratory.
Can this test diagnose Budd-Chiari syndrome?
No. The test identifies inherited genetic risk factors that may contribute to Budd-Chiari syndrome. The diagnosis of Budd-Chiari syndrome is made with imaging and clinical findings.
What does a positive result mean?
A positive result means a pathogenic or likely pathogenic variant was found in the F5 gene. It indicates a higher risk for blood clotting, but it does not mean the patient will certainly develop Budd-Chiari syndrome.
What does a negative result mean?
A negative result means no clinically significant F5 variant was detected. It reduces the likelihood of F5-related thrombophilia but does not exclude all hereditary or acquired causes of Budd-Chiari syndrome.
Will insurance cover this genetic test?
Insurance coverage varies by policy, clinical indication, and insurance provider. You should check with your insurer or contact our billing team before booking.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection for online bookings for this test in multiple cities across India. Our trained phlebotomist will collect the sample from your desired location.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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